Empagliflozin attenuates neurodegeneration through antioxidant, anti-inflammatory, and modulation of α-synuclein and Parkin levels in rotenone-induced Parkinson’s disease in rats

Descriptive epidemiological study on patients with movement disorders, with emphasis on Parkinson’s disease

(2021) Luiza Serafini Balestrassi et al.   Sao Paulo Medical Journal

Targeting ROS-Dependent AKT/GSK-3β/NF-κB and DJ-1/Nrf2 Pathways by Dapagliflozin Attenuates Neuronal Injury and Motor Dysfunction in Rotenone-Induced Parkinson’s Disease Rat Model

(2021) Hany H. Arab et al.   ACS Chemical Neuroscience

TLR7 and IL-6 differentially regulate the effects of rotarod exercise on the transcriptomic profile and neurogenesis to influence anxiety and memory

(2021) Yun-Fen Hung et al.   iScience

Carvedilol induces the antiapoptotic proteins Nrf2 and Bcl2 and inhibits cellular apoptosis in aluminum-induced testicular toxicity in male Wistar rats

(2021) Sanaa A. Ahmed et al.   BIOMEDICINE & PHARMACOTHERAPY

Two Birds One Stone: The Neuroprotective Effect of Antidiabetic Agents on Parkinson Disease—Focus on Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors

(2021) Kai-Jung Lin et al.   Antioxidants

Recent advances in dopaminergic strategies for the treatment of Parkinson’s disease

(2020) Qi Mao et al.   ACTA PHARMACOLOGICA SINICA

Empagliflozin attenuates transient cerebral ischemia/reperfusion injury in hyperglycemic rats via repressing oxidative–inflammatory–apoptotic pathway

(2020) Entesar F. Amin et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

C/EBPβ/δ-secretase signaling mediates Parkinson’s disease pathogenesis via regulating transcription and proteolytic cleavage of α-synuclein and MAOB

(2020) Zhourui Wu et al.   MOLECULAR PSYCHIATRY

Sodium–glucose cotransporters: Functional properties and pharmaceutical potential

(2020) Ryuhei Sano et al.   Journal of Diabetes Investigation

Empagliflozin ameliorates ethanol-induced liver injury by modulating NF-κB/Nrf-2/PPAR-γ interplay in mice

(2020) Amir Mohamed Abdelhamid et al.   LIFE SCIENCES

Hepcidin Decreases Rotenone-Induced α-Synuclein Accumulation via Autophagy in SH-SY5Y Cells

(2020) Meiqi Li et al.   Frontiers in Molecular Neuroscience

Cerebellar GABA Levels and Cognitive Interference in Parkinson’s disease and Healthy Comparators

(2020) Federica Piras et al.   Journal of Personalized Medicine

Neuroprotection of Fasting Mimicking Diet on MPTP-Induced Parkinson’s Disease Mice via Gut Microbiota and Metabolites

(2019) Zhi-Lan Zhou et al.   Neurotherapeutics

Empagliflozin for the Treatment of Nonalcoholic Steatohepatitis in Patients with Type 2 Diabetes Mellitus

(2019) Lee-Lee Lai et al.   DIGESTIVE DISEASES AND SCIENCES

SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart

(2019) Chenguang Li et al.   Cardiovascular Diabetology

Methyl jasmonate abrogates rotenone-induced parkinsonian-like symptoms through inhibition of oxidative stress, release of pro-inflammatory cytokines, and down-regulation of immnopositive cells of NF-κB and α-synuclein expressions in mice

(2019) Akinyinka O. Alabi et al.   NEUROTOXICOLOGY

Neuroprotective effects of mitochondria‐targeted curcumin against rotenone‐induced oxidative damage in cerebellum of mice

(2019) Whidul Hasan et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Nonpharmacological Modulation of Chronic Inflammation in Parkinson’s Disease: Role of Diet Interventions

(2019) Stefania Kalampokini et al.   Parkinsons Disease

Anti-inflammatory activities of Waltheria indica extracts by modulating expression of IL-1B, TNF-α, TNFRII and NF-κB in human macrophages

(2019) Rozalia Laczko et al.   INFLAMMOPHARMACOLOGY

The catecholaldehyde hypothesis: where MAO fits in

(2019) David S. Goldstein   JOURNAL OF NEURAL TRANSMISSION

Human tyrosine hydroxylase in Parkinson’s disease and in related disorders

(2018) Toshiharu Nagatsu et al.   JOURNAL OF NEURAL TRANSMISSION

Oxidative Stress in Parkinson's Disease: A Systematic Review and Meta-Analysis

(2018) Zexu Wei et al.   Frontiers in Molecular Neuroscience

Caffeic acid improves locomotor activity and lessens inflammatory burden in a mouse model of rotenone-induced nigral neurodegeneration: Relevance to Parkinson’s disease therapy

(2018) Sawsan A. Zaitone et al.   Pharmacological Reports

Montelukast attenuates rotenone-induced microglial activation/p38 MAPK expression in rats: Possible role of its antioxidant, anti-inflammatory and antiapoptotic effects

(2018) Riham M. Mansour et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

PPAR-γ agonist pioglitazone reduces microglial proliferation and NF-κB activation in the substantia nigra in the 6-hydroxydopamine model of Parkinson’s disease

(2018) Meira Maria Forcelini Machado et al.   Pharmacological Reports

K-variant BCHE and pesticide exposure: Gene-environment interactions in a case–control study of Parkinson’s disease in Egypt

(2018) Thomas W. Rösler et al.   Scientific Reports

Brain Ceruloplasmin Expression After Experimental Intracerebral Hemorrhage and Protection Against Iron-Induced Brain Injury

(2018) Hongwei Liu et al.   Translational Stroke Research

The effect of docosahexaenoic acid on apelin distribution of nervous system in the experimental mouse model of Parkinson’s disease

(2018) Nuray Acar et al.   TISSUE & CELL

Role of the sympathetic nervous system in regulation of the sodium glucose cotransporter 2

(2017) Vance B. Matthews et al.   JOURNAL OF HYPERTENSION

Lack of Parkin anticipates the phenotype and affects mitochondrial morphology and mtDNA levels in a mouse model of Parkinson's Disease

(2017) Milena Pinto et al.   JOURNAL OF NEUROSCIENCE

On the role of endogenous neurotoxins and neuroprotection in Parkinson's disease

(2017) Juan Segura-Aguilar   Neural Regeneration Research

Alpha-synuclein activates BV2 microglia dependent on its aggregation state

(2016) Alana Hoffmann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of metformin on inflammation and short-term memory in streptozotocin-induced diabetic mice

(2016) Wilma Helena Oliveira et al.   BRAIN RESEARCH

The beneficial effects of empagliflozin, an SGLT2 inhibitor, on atherosclerosis in ApoE −/− mice fed a western diet

(2016) Ji Hye Han et al.   DIABETOLOGIA

Empagliflozin (an SGLT2 inhibitor), alone or in combination with linagliptin (a DPP-4 inhibitor), prevents steatohepatitis in a novel mouse model of non-alcoholic steatohepatitis and diabetes

(2016) Teruo Jojima et al.   Diabetology & Metabolic Syndrome

Effect of Sodium-Glucose Co-Transporter 2 Inhibitor, Dapagliflozin, on Renal Renin-Angiotensin System in an Animal Model of Type 2 Diabetes

(2016) Seok Joon Shin et al.   PLoS One

N-acetylcysteine prevents rotenone-induced Parkinson's disease in rat: An investigation into the interaction of parkin and Drp1 proteins

(2015) Arman Rahimmi et al.   BRAIN RESEARCH BULLETIN

Neuroprotective effects of vildagliptin in rat rotenone Parkinson's disease model: role of RAGE-NFκB and Nrf2-antioxidant signaling pathways

(2015) Rania M. Abdelsalam et al.   JOURNAL OF NEUROCHEMISTRY

Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease

(2015) W. Liu et al.   NEUROSCIENCE

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

(2015) Bernard Zinman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Copper and Copper Proteins in Parkinson’s Disease

(2014) Sergio Montes et al.   Oxidative Medicine and Cellular Longevity

Stain-Free total protein staining is a superior loading control to β-actin for Western blots

(2013) Jennifer E. Gilda et al.   ANALYTICAL BIOCHEMISTRY

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys

(2013) Ariadna Recasens et al.   ANNALS OF NEUROLOGY

Antioxidant Effects of Nerolidol in Mice Hippocampus After Open Field Test

(2013) José Damasceno Nogueira Neto et al.   NEUROCHEMICAL RESEARCH

Role of Oxidative Stress in Parkinson's Disease

(2013) Onyou Hwang   Experimental Neurobiology

Anti-inflammatory properties rather than anti-oxidant capability is the major mechanism of neuroprotection by sodium salicylate in a chronic rotenone model of Parkinson’s disease

(2012) P. Thakur et al.   NEUROSCIENCE

Ceruloplasmin Protects Against Rotenone-Induced Oxidative Stress and Neurotoxicity

(2011) Akiyo Hineno et al.   NEUROCHEMICAL RESEARCH

Protective Effect of Lycopene on Oxidative Stress and Cognitive Decline in Rotenone Induced Model of Parkinson’s Disease

(2011) Harpreet Kaur et al.   NEUROCHEMICAL RESEARCH

Functional expression of SGLTs in rat brain

(2010) Amy S. Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Unregulated Cytosolic Dopamine Causes Neurodegeneration Associated with Oxidative Stress in Mice

(2008) L. Chen et al.   JOURNAL OF NEUROSCIENCE