Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson’s disease models

Parkinsonian Rotenone Mouse Model: Reevaluation of Long-Term Administration of Rotenone in C57BL/6 Mice

(2011) Masatoshi Inden et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Characterisation of a novel model of Parkinson's disease by intra-striatal infusion of the pesticide rotenone

(2011) P. Mulcahy et al.   NEUROSCIENCE

Glyceraldehyde-3-phosphate dehydrogenase: activity inhibition and protein overexpression in rotenone models for Parkinson's disease

(2011) J. Huang et al.   NEUROSCIENCE

Potential autophagy enhancers attenuate rotenone-induced toxicity in SH-SY5Y

(2011) N. Xiong et al.   NEUROSCIENCE

Edaravone Guards Dopamine Neurons in a Rotenone Model for Parkinson's Disease

(2011) Nian Xiong et al.   PLoS One

The MAP kinase Pmk1 and protein kinase A are required for rotenone resistance in the fission yeast, Schizosaccharomyces pombe

(2010) Yiwei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Long-Term Efficacy and Safety of Human Umbilical Cord Mesenchymal Stromal Cells in Rotenone-Induced Hemiparkinsonian Rats

(2010) Nian Xiong et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Progressive loss of dopaminergic neurons induced by unilateral rotenone infusion into the medial forebrain bundle

(2010) Anwar Norazit et al.   BRAIN RESEARCH

Detoxified Extract of Rhus verniciflua Stokes Inhibits Rotenone-Induced Apoptosis in Human Dopaminergic Cells, SH-SY5Y

(2010) Kumar Sapkota et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

High regulatability favors genetic selection in SLC18A2, a vesicular monoamine transporter essential for life

(2010) Zhicheng Lin et al.   FASEB JOURNAL

VEGF-expressing human umbilical cord mesenchymal stem cells, an improved therapy strategy for Parkinson’s disease

(2010) N Xiong et al.   GENE THERAPY

Quantitative autoradiographic study on receptor regulation in the basal ganglia in rat model of levodopa-induced motor complications

(2010) Yan Xu et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

A neuroprotective role for angiogenin in models of Parkinson’s disease

(2010) Trent U. Steidinger et al.   JOURNAL OF NEUROCHEMISTRY

Agmatine effects on mitochondrial membrane potential andNF-κB activation protect against rotenone-induced cell damage in human neuronal-like SH-SY5Y cells

(2010) Salvatore Condello et al.   JOURNAL OF NEUROCHEMISTRY

Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease

(2010) Giuseppe Filomeni et al.   NEUROBIOLOGY OF AGING

The Drosophila vesicular monoamine transporter reduces pesticide-induced loss of dopaminergic neurons

(2010) Hakeem O. Lawal et al.   NEUROBIOLOGY OF DISEASE

Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's disease

(2010) Florian Bayersdorfer et al.   NEUROBIOLOGY OF DISEASE

Phenothiazines interfere with dopaminergic neurodegeneration in Caenorhabditis elegans models of Parkinson's disease

(2010) Justyna B. Mocko et al.   NEUROBIOLOGY OF DISEASE

Integrating multiple aspects of mitochondrial dynamics in neurons: Age-related differences and dynamic changes in a chronic rotenone model

(2010) Beth Arnold et al.   NEUROBIOLOGY OF DISEASE

Mechanisms of rotenone-induced proteasome inhibition

(2010) Arthur P. Chou et al.   NEUROTOXICOLOGY

Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice

(2010) Francisco Pan-Montojo et al.   PLoS One

Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated with serotonin and dopamine

(2010) Ronise M. Santiago et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Parkinson's disease: Insights from non-traditional model organisms

(2010) Ilse S. Pienaar et al.   PROGRESS IN NEUROBIOLOGY

Neuroprotective effects of hydrogen sulfide on Parkinson’s disease rat models

(2009) Li-Fang Hu et al.   AGING CELL

Rotenone Damages Striatal Organotypic Slice Culture

(2009) Rudolf Moldzio et al.   Annals of the New York Academy of Sciences

DNA polymerase-β is required for 1-methyl-4-phenylpyridinium-induced apoptotic death in neurons

(2009) Zhentao Zhang et al.   APOPTOSIS

Involvement of glyceraldehyde-3-phosphate dehydrogenase in rotenone-induced cell apoptosis: Relevance to protein misfolding and aggregation

(2009) Jinsha Huang et al.   BRAIN RESEARCH

Acute action of rotenone on nigral dopaminergic neurons - involvement of reactive oxygen species and disruption of Ca2+homeostasis

(2009) Peter S. Freestone et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

C-terminal mechano growth factor protects dopamine neurons: A novel peptide that induces heme oxygenase-1

(2009) Arnulfo Quesada et al.   EXPERIMENTAL NEUROLOGY

Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease

(2009) James G. Greene et al.   EXPERIMENTAL NEUROLOGY

Oxidants induce alternative splicing of α-synuclein: Implications for Parkinson's disease

(2009) Shasi V. Kalivendi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

(2009) K. Venderova et al.   HUMAN MOLECULAR GENETICS

Effects of epigallocatechin gallate on rotenone-injured murine brain cultures

(2009) Rudolf Moldzio et al.   JOURNAL OF NEURAL TRANSMISSION

Novel imine antioxidants at low nanomolar concentrations protect dopaminergic cells from oxidative neurotoxicity

(2009) Parvana Hajieva et al.   JOURNAL OF NEUROCHEMISTRY

LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans

(2009) S. Saha et al.   JOURNAL OF NEUROSCIENCE

Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease

(2009) Ming Ming et al.   Journal of Translational Medicine

Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment

(2009) K Ray Chaudhuri et al.   LANCET NEUROLOGY

Effects of chronic low dose rotenone treatment on human microglial cells

(2009) Shamim B Shaikh et al.   Molecular Neurodegeneration

A highly reproducible rotenone model of Parkinson's disease

(2009) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology

(2009) Robert E. Drolet et al.   NEUROBIOLOGY OF DISEASE

VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease

(2009) Qingmin Ruan et al.   NEUROBIOLOGY OF DISEASE

Induction of heat shock protein 70 reduces the alteration of striatal electrical activity caused by mitochondrial impairment

(2009) M. Tantucci et al.   NEUROSCIENCE

Rapamycin protects against rotenone-induced apoptosis through autophagy induction

(2009) T. Pan et al.   NEUROSCIENCE

Synphilin-1 exhibits trophic and protective effects against Rotenone toxicity

(2009) X. Li et al.   NEUROSCIENCE

HDAC inhibitor trichostatin A-inhibited survival of dopaminergic neuronal cells

(2009) Yong Wang et al.   NEUROSCIENCE LETTERS

Valproic Acid is Neuroprotective in the Rotenone Rat Model of Parkinson’s Disease: Involvement of α-Synuclein

(2009) Barbara Monti et al.   NEUROTOXICITY RESEARCH

Rotenone reduces Mg2+-dependent block of NMDA currents in substantia nigra dopamine neurons

(2009) Yan-Na Wu et al.   NEUROTOXICOLOGY

Stereotaxical Infusion of Rotenone: A Reliable Rodent Model for Parkinson's Disease

(2009) Nian Xiong et al.   PLoS One

Inhibition by rotenone of mesencephalic neural stem-cell migration in a neurosphere assay in vitro

(2009) Masami Ishido et al.   TOXICOLOGY IN VITRO

Vascular Pathology in Male Lewis Rats following Short-Term, Low-Dose Rotenone Administration

(2009) A. L. Allen et al.   VETERINARY PATHOLOGY

Parkinson-Linked Genes and Toxins That Affect Neuronal Cell Death Through the Bcl-2 Family

(2008) Douglas W. Ethell et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

(2008) T. Pan et al.   BRAIN

Behavioral alterations in rotenone model of Parkinson's disease: Attenuation by co-treatment of centrophenoxine

(2008) Bimla Nehru et al.   BRAIN RESEARCH

Role of reactive oxygen species in the neurotoxicity of environmental agents implicated in Parkinson's disease

(2008) Derek A. Drechsel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Opening of microglial KATPchannels inhibits rotenone-induced neuroinflammation

(2008) Fang Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Combined R-α-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson’s disease

(2008) Hongyu Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Advanced glycation end products induce in vitro cross‐linking of α‐synuclein and accelerate the process of intracellular inclusion body formation

(2008) Shamim Shaikh et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models

(2008) Hiroki Takeuchi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

LRRK2: bridging the gap between sporadic and hereditary Parkinson's disease

(2008) Alexis Elbaz   LANCET NEUROLOGY

Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells

(2008) M Kathleen Borland et al.   Molecular Neurodegeneration

Mitochondrial Complex I Inhibitor Rotenone Inhibits and Redistributes Vesicular Monoamine Transporter 2 via Nitration in Human Dopaminergic SH-SY5Y Cells

(2008) M. Watabe et al.   MOLECULAR PHARMACOLOGY

Low dose rotenone treatment causes selective transcriptional activation of cell death related pathways in dopaminergic neurons in vivo

(2008) B.H. Meurers et al.   NEUROBIOLOGY OF DISEASE

DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone

(2008) Steven J. Mullett et al.   NEUROBIOLOGY OF DISEASE

Protective Effects of Asiatic Acid on Rotenone- or H2O2-Induced Injury in SH-SY5Y Cells

(2008) Yuyun Xiong et al.   NEUROCHEMICAL RESEARCH

Investigating Convergent Actions of Genes Linked to Familial Parkinson’s Disease

(2008) Benjamin Wolozin et al.   Neurodegenerative Diseases

Mechanism of the neuroprotective role of coenzyme Q10 with or without L-dopa in rotenone-induced parkinsonism

(2008) Amany A. Abdin et al.   NEUROPHARMACOLOGY

Oxidative insults induce DJ-1 upregulation and redistribution: Implications for neuroprotection

(2008) Nirit Lev et al.   NEUROTOXICOLOGY

Progress in Parkinson's disease—Where do we stand?

(2008) André Toulouse et al.   PROGRESS IN NEUROBIOLOGY

Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism

(2008) Yan Sai et al.   TOXICOLOGY IN VITRO

Pesticide/Environmental Exposures and Parkinson's Disease in East Texas

(2008) Amanpreet S. Dhillon et al.   Journal of Agromedicine

Sequential and concerted gene expression changes in a chronic in vitro model of parkinsonism

(2007) J.G. Greene et al.   NEUROSCIENCE

The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK–PD experiments

(2007) Paulien G.M. Ravenstijn et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS