TRIM21 Regulates Virus-Induced Cell Pyroptosis through Polyubiquitination of ISG12a

Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis

(2022) Wanyan Deng et al.   NATURE

The role of TRIM family proteins in autophagy, pyroptosis and diabetes mellitus

(2021) Tingting Wan et al.   CELL BIOLOGY INTERNATIONAL

The noncoding RNAs SNORD50A and SNORD50B-mediated TRIM21-GMPS interaction promotes the growth of p53 wild-type breast cancers by degrading p53

(2021) Xi Su et al.   CELL DEATH AND DIFFERENTIATION

TRIM10 binds to IFN‐α/β receptor 1 to negatively regulate type I IFN signal transduction

(2021) Mengmeng Guo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells

(2021) Megan H. Orzalli et al.   IMMUNITY

TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization

(2021) Wenqing Gao et al.   CELL DEATH AND DIFFERENTIATION

Up-regulation of gasdermin C in mouse small intestine is associated with lytic cell death in enterocytes in worm-induced type 2 immunity

(2021) Ranhui Xi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins

(2021) Elke De Schutter et al.   TRENDS IN CELL BIOLOGY

TRIM25 inhibits infectious bursal disease virus replication by targeting VP3 for ubiquitination and degradation

(2021) Suyan Wang et al.   PLoS Pathogens

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

A bioorthogonal system reveals antitumour immune function of pyroptosis

(2020) Qinyang Wang et al.   NATURE

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

(2020) Zhiwei Zhou et al.   SCIENCE

Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate

(2020) Lei Hu et al.   Cell Death & Disease

TRIM22 activates NF-κB signaling in glioblastoma by accelerating the degradation of IκBα

(2020) Jianxiong Ji et al.   CELL DEATH AND DIFFERENTIATION

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

(2020) Junwei Hou et al.   NATURE CELL BIOLOGY

Neural progenitor cell pyroptosis contributes to Zika virus-induced brain atrophy and represents a therapeutic target

(2020) Zhenjian He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFI27/ISG12 Downregulates Estrogen Receptor α Transactivation by Facilitating Its Interaction With CRM1/XPO1 in Breast Cancer Cells

(2020) Mayte Guadalupe Cervantes-Badillo et al.   Frontiers in Endocrinology

The antiviral activities of TRIM proteins

(2020) Lennart Koepke et al.   CURRENT OPINION IN MICROBIOLOGY

ISG12a and its interaction partner NR4A1 are involved in TRAIL-induced apoptosis in hepatoma cells

(2019) Nianli Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly

(2019) Kaiwen W Chen et al.   EMBO JOURNAL

The Coming Decade of Cell Death Research: Five Riddles

(2019) Douglas R. Green   CELL

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Methylation analysis of Gasdermin E shows great promise as a biomarker for colorectal cancer

(2019) Joe Ibrahim et al.   Cancer Medicine

The Gasdermin E gene Potential as a Pan-Cancer Biomarker, While Discriminating between Different Tumor Types

(2019) Joe Ibrahim et al.   Cancers

TRIM 21‐mediated proteasomal degradation of SAMHD 1 regulates its antiviral activity

(2019) Zhaolong Li et al.   EMBO REPORTS

Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection

(2018) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

TRIM21 Promotes Innate Immune Response to RNA Viral Infection through Lys27-Linked Polyubiquitination of MAVS

(2018) Binbin Xue et al.   JOURNAL OF VIROLOGY

Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses

(2018) Tanggang Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

ISG12a inhibits HCV replication and potentiates the anti-HCV activity of IFN-α through activation of the Jak/STAT signaling pathway independent of autophagy and apoptosis

(2017) Yanzhao Chen et al.   VIRUS RESEARCH

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway

(2016) Binbin Xue et al.   JOURNAL OF VIROLOGY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

MiR-942 Mediates Hepatitis C Virus-Induced Apoptosis via Regulation of ISG12a

(2014) Darong Yang et al.   PLoS One

ISG12a mediates cell response to Newcastle disease viral infection

(2014) Nianli Liu et al.   VIROLOGY

The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA

(2012) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

TRIM21 Is Essential to Sustain IFN Regulatory Factor 3 Activation during Antiviral Response

(2009) K. Yang et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a

(2008) Shaun Rosebeck et al.   APOPTOSIS