Type 2 Diabetes Mellitus and Alzheimer’s Disease: Shared Molecular Mechanisms and Potential Common Therapeutic Targets

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Tau Ubiquitination in Alzheimer's Disease

(2022) Longfei Li et al.   Frontiers in Neurology

Significance of Brain Glucose Hypometabolism, Altered Insulin Signal Transduction, and Insulin Resistance in Several Neurological Diseases

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Exposure to Endocrine-Disrupting Chemicals and Type 2 Diabetes Mellitus in Later Life

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DYRK1a Inhibitor Mediated Rescue of Drosophila Models of Alzheimer’s Disease-Down Syndrome Phenotypes

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Dysfunctional Glucose Metabolism in Alzheimer’s Disease Onset and Potential Pharmacological Interventions

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Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age‐dependent manner, normalizes GABA‐activated currents in the tg‐APPSwe mouse model of Alzheimer’s disease

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Vascular Hypothesis of Alzheimer Disease

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GSK-3 and Tau: A Key Duet in Alzheimer’s Disease

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Insulin Action in the Brain regulates both Central and Peripheral Functions

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Brain Glucose Transporters: Role in Pathogenesis and Potential Targets for the Treatment of Alzheimer’s Disease

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Insulin Resistance Exacerbates Alzheimer Disease via Multiple Mechanisms

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A natural DYRK1A inhibitor as a potential stimulator for β‐cell proliferation in diabetes

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Brain-Derived Neurotrophic Factor and Diabetes

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Islet Amyloid Polypeptide: A Partner in Crime With Aβ in the Pathology of Alzheimer's Disease

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Peripheral clearance of brain-derived Aβ in Alzheimer's disease: pathophysiology and therapeutic perspectives

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Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes

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Link between Diabetes and Alzheimer’s Disease Due to the Shared Amyloid Aggregation and Deposition Involving Both Neurodegenerative Changes and Neurovascular Damages

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Tauopathy: A common mechanism for neurodegeneration and Brain Aging

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Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain

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Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice

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Understanding the link between insulin resistance and Alzheimer’s disease: Insights from animal models

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Insulin treatment protects the brain against neuroinflammation by reducing cerebral cytokines and modulating mitochondrial function

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Hypothesis and Theory: Circulating Alzheimer's-Related Biomarkers in Type 2 Diabetes. Insight From the Goto-Kakizaki Rat

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Insulin resistance and hippocampal dysfunction: Disentangling peripheral and brain causes from consequences

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Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain

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Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects

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Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway

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Brain Insulin Resistance and Hippocampal Plasticity: Mechanisms and Biomarkers of Cognitive Decline

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Implication of glycogen synthase kinase 3 in diabetes-associated islet inflammation

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The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer’s disease in rodents

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Global Economic Burden of Diabetes in Adults: Projections From 2015 to 2030

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Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

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Impaired peripheral glucose homeostasis and Alzheimer's disease

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Connecting Alzheimer's disease to diabetes: Underlying mechanisms and potential therapeutic targets

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Intranasal insulin in Alzheimer's disease: Food for thought

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Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review

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Alzheimer's disease and Type 2 Diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline

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Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity

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Intrahippocampal Administration of Amyloid-β1-42 Oligomers Acutely Impairs Spatial Working Memory, Insulin Signaling, and Hippocampal Metabolism

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Diabetes and Alzheimer’s Disease: A Link not as Simple as it Seems

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Insulin Resistance in Alzheimer's Disease

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The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins

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Bidirectional interactions between diabetes and Alzheimer's disease

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Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging

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Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer’s Disease

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Insulin Resistance and Alzheimer’s Disease: Bioenergetic Linkages

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Accumulated Amyloid-β Peptide and Hyperphosphorylated Tau Protein: Relationship and Links in Alzheimer's Disease

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Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice

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Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels

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Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

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DYRK1A: A Promising Drug Target for Islet Transplant–Based Diabetes Therapies

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The amyloid hypothesis of Alzheimer's disease at 25 years

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Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

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Diabetes and Alzheimer’s disease crosstalk

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DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome

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Meta-Analysis of Serum Insulin-Like Growth Factor 1 in Alzheimer’s Disease

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Alzheimer-associated A  oligomers impact the central nervous system to induce peripheral metabolic deregulation

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Critical analysis of Alzheimer rsquo s amyloid-beta nbsp toxicity to mitochondria

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A novel DYRK1A (Dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologiesin vitro

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Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains

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Brain Insulin Administration Triggers Distinct Cognitive and Neurotrophic Responses in Young and Aged Rats

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A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

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Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

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Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment

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Aberrant insulin signaling in Alzheimer's disease: current knowledge

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The Brain Response to Peripheral Insulin Declines with Age: A Contribution of the Blood-Brain Barrier?

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Insulin can induce the expression of a memory-related synaptic protein through facilitating AMPA receptor endocytosis in rat cortical neurons

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Islet Amyloid Polypeptide (IAPP): A Second Amyloid in Alzheimer's Disease

(2014) Janelle Fawver et al.   Current Alzheimer Research

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

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GLP-1 and Exendin-4 Transiently Enhance GABAAReceptor–Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons

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Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

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Brain Changes Underlying Cognitive Dysfunction in Diabetes: What Can We Learn From MRI?

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Type 3 diabetes is sporadic Alzheimer׳s disease: Mini-review

(2014) Suzanne M. de la Monte   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Diabetes Mellitus and the Risk of Alzheimer’s Disease: A Nationwide Population-Based Study

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Evidence for altered transport of insulin across the blood–brain barrier in insulin-resistant humans

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Amylin deposition in the brain: A second amyloid in Alzheimer disease?

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Insulin, cognition, and dementia

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Impaired glycemia increases disease progression in mild cognitive impairment

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Molecular links between Alzheimer’s disease and diabetes mellitus

(2013) Y. Yang et al.   NEUROSCIENCE

Influence of Chronic Hyperglycemia on Cerebral Microvascular Remodeling

(2013) Qinghua Hou et al.   STROKE

Sugar for the brain: the role of glucose in physiological and pathological brain function

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Evidence for impaired amyloid β clearance in Alzheimer's disease

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Neurovascular Dysfunction and Faulty Amyloid  -Peptide Clearance in Alzheimer Disease

(2013) A. P. Sagare et al.   Cold Spring Harbor Perspectives in Medicine

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

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Increased Aβ production prompts the onset of glucose intolerance and insulin resistance

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Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease

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The Role of Glucose Transporters in Brain Disease: Diabetes and Alzheimer's Disease

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Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model

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An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

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Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

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Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

(2012) Philip T.T. Ly et al.   JOURNAL OF CLINICAL INVESTIGATION

Local In Vivo GSK3β Knockdown Promotes Pancreatic β Cell and Acinar Cell Regeneration in 90% Pancreatectomized Rat

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JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides

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Insulin in the brain: There and back again

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(2012) A. Limon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low BDNF is associated with cognitive deficits in patients with type 2 diabetes

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GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease

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Cerebrovascular Complications of Diabetes: Focus on Stroke

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Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

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Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats

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Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial

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Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

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Contributions of Brain Insulin Resistance and Deficiency in Amyloid-Related Neurodegeneration in Alzheimerʼs Disease

(2011) Suzanne M. de la Monte   DRUGS

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

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Apolipoprotein E in Alzheimer's disease and other neurological disorders

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Endocrine disruptors in the etiology of type 2 diabetes mellitus

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The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

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Brain-Derived Neurotrophic Factor and Alzheimer’s Disease: Physiopathology and Beyond

(2011) Breno Satler Diniz et al.   NEUROMOLECULAR MEDICINE

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Untreated Type 2 Diabetes and Its Complications Are Associated With Subcortical Infarctions

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MNB/DYRK1A as a multiple regulator of neuronal development

(2010) Francisco J. Tejedor et al.   FEBS Journal

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The role of DYRK1A in neurodegenerative diseases

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Dyrk1A-mediated phosphorylation of Presenilin 1: a functional link between Down syndrome and Alzheimer’s disease

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Hippocampal long-term depression is required for the consolidation of spatial memory

(2010) Y. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A  deposition in an Alzheimer mouse model with diabetes

(2010) S. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ and human amylin share a common toxicity pathwayviamitochondrial dysfunction

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Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Microvasculature changes and cerebral amyloid angiopathy in Alzheimer’s disease and their potential impact on therapy

(2009) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Neonatal growth and regeneration of β-cells are regulated by the Wnt/β-catenin signaling in normal and diabetic rats

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Common features between diabetes mellitus and Alzheimer’s disease

(2009) J. Götz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Function and regulation of Dyrk1A: towards understanding Down syndrome

(2009) Joongkyu Park et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

GSK3: A possible link between beta amyloid peptide and tau protein

(2009) Félix Hernández et al.   EXPERIMENTAL NEUROLOGY

Cognitive impairment in nondiabetic middle-aged and older adults is associated with insulin resistance

(2009) H. Bruehl et al.   JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

(2008) Jerzy Wegiel et al.   ACTA NEUROPATHOLOGICA

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

(2008) Wei-Qin Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

(Pre)diabetes, brain aging, and cognition

(2008) Jarbas S. Roriz-Filho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance

(2008) Aya Fujinami et al.   CLINICAL BIOCHEMISTRY

Mice with beta cell overexpression of glycogen synthase kinase-3β have reduced beta cell mass and proliferation

(2008) Z. Liu et al.   DIABETOLOGIA

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

(2008) Fei Liu et al.   FASEB JOURNAL

Amyloid-β Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/β-Catenin Signaling

(2008) Margaret H. Magdesian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Dosage of Dyrk1A Alters Alternative Splicing Factor (ASF)-regulated Alternative Splicing of Tau in Down Syndrome

(2008) Jianhua Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ubiquitin-proteasome system in Alzheimer's disease

(2008) Salvatore Oddo   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

(2008) Judith Miklossy et al.   NEUROBIOLOGY OF AGING

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING

Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo

(2008) Shu-Ling Chiu et al.   NEURON

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL

Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer’s disease

(2007) Soo-Ryoon Ryoo et al.   JOURNAL OF NEUROCHEMISTRY