m(6)A methyltransferase METTL3 relieves cognitive impairment of hyperuricemia mice via inactivating MyD88/NF-κB pathway mediated NLRP3-ASC-Caspase1 inflammasome

LncRNA NEAT1 activates MyD88/NF-κB pathway in bronchopneumonia through targeting miR-155-5p

(2021) Ling-jia Chen et al.   AUTOIMMUNITY

Rifampicin ameliorates lipopolysaccharide-induced cognitive and motor impairments via inhibition of the TLR4/MyD88/NF-κB signaling pathway in mice

(2021) Wei Bi et al.   NEUROLOGICAL RESEARCH

Detrimental effects of long-term elevated serum uric acid on cognitive function in rats

(2021) Tian Tian et al.   Scientific Reports

LncRNA‐HOTAIR promotes endothelial cell pyroptosis by regulating the miR‐22/NLRP3 axis in hyperuricaemia

(2021) Kun Chi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mangiferin Ameliorates Hyperuricemic Nephropathy Which Is Associated With Downregulation of AQP2 and Increased Urinary Uric Acid Excretion

(2020) Xuechen Li et al.   Frontiers in Pharmacology

USP8 protects against lipopolysaccharide-induced cognitive and motor deficits by modulating microglia phenotypes through TLR4/MyD88/NF-κB signaling pathway in mice

(2020) JiaYi Zhao et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype

(2020) Baohua Hou et al.   Cell Death & Disease

Methyltransferase 3 Mediated miRNA m6A Methylation Promotes Stress Granule Formation in the Early Stage of Acute Ischemic Stroke

(2020) Wenwen Si et al.   Frontiers in Molecular Neuroscience

LIGHT aggravates sepsis‐associated acute kidney injury via TLR4‐MyD88‐NF‐κB pathway

(2020) Yu Zhong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Roles of METTL3 in cancer: mechanisms and therapeutic targeting

(2020) Chengwu Zeng et al.   Journal of Hematology & Oncology

N6-methyladenosine METTL3 promotes cervical cancer tumorigenesis and Warburg effect through YTHDF1/HK2 modification

(2020) Qianqing Wang et al.   Cell Death & Disease

Glycyrrhizic Acid Improves Cognitive Levels of Aging Mice by Regulating T/B Cell Proliferation

(2020) Ruichan Jiang et al.   Frontiers in Aging Neuroscience

Altered Expression of the m6A Methyltransferase METTL3 in Alzheimer’s Disease

(2020) He Huang et al.   eNeuro

Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF-κB signaling pathway

(2019) Xin Jin et al.   CNS Neuroscience & Therapeutics

m6A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2

(2019) Junchen Chen et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

(2019) Jie Han et al.   Molecular Cancer

m6A methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways

(2019) Ru Deng et al.   OncoTargets and Therapy

Curcumin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation in mice

(2019) Yonger Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Pharmacological Inhibitors of the NLRP3 Inflammasome

(2019) Ayesha Zahid et al.   Frontiers in Immunology

Effect of Eurycoma longifolia Stem Extract on Uric Acid Excretion in Hyperuricemia Mice

(2019) Ruixia Bao et al.   Frontiers in Pharmacology

Inhibition of microRNA-210 suppresses pro-inflammatory response and reduces acute brain injury of ischemic stroke in mice

(2018) Lei Huang et al.   EXPERIMENTAL NEUROLOGY

METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells

(2018) Zhihui Feng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Uric Acid and Cognitive Function in Older Individuals

(2018) Claudio Tana et al.   Nutrients

METTL3-mediated N6-methyladenosine mRNA modification enhances long-term memory consolidation

(2018) Zeyu Zhang et al.   CELL RESEARCH

Relationship between oxidative stress and inflammation in hyperuricemia

(2018) You Zhou et al.   MEDICINE

m6A facilitates hippocampus-dependent learning and memory through YTHDF1

(2018) Hailing Shi et al.   NATURE

Uric acid may be protective against cognitive impairment in older adults, but only in those without cardiovascular risk factors

(2017) Busra Tuven et al.   EXPERIMENTAL GERONTOLOGY

Down-regulation of liver-intestine cadherin enhances noscapine-induced apoptosis in human colon cancer cells

(2017) Xia Tian et al.   Expert Review of Anticancer Therapy

m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

(2017) Qi Cui et al.   Cell Reports

Hyperuricemia, Hypertension, and Chronic Kidney Disease: an Emerging Association

(2016) Samir G. Mallat et al.   CURRENT HYPERTENSION REPORTS

Uric Acid Induces Cognitive Dysfunction through Hippocampal Inflammation in Rodents and Humans

(2016) X. Shao et al.   JOURNAL OF NEUROSCIENCE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Endocytosis of indium-tin-oxide nanoparticles by macrophages provokes pyroptosis requiring NLRP3-ASC-Caspase1 axis that can be prevented by mesenchymal stem cells

(2016) Abderrahim Naji et al.   Scientific Reports

High Uric Acid Induces Insulin Resistance in Cardiomyocytes In Vitro and In Vivo

(2016) Li Zhi et al.   PLoS One

Soluble uric acid increases NALP3 inflammasome and interleukin-1β expression in human primary renal proximal tubule epithelial cells through the Toll-like receptor 4-mediated pathway

(2015) JING XIAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Serum uric acid and the risk of cardiovascular and renal disease

(2015) Claudio Borghi et al.   JOURNAL OF HYPERTENSION

Changes in Renal Function and Oxidative Status Associated with the Hypotensive Effects of Oleanolic Acid and Related Synthetic Derivatives in Experimental Animals

(2015) Hlengiwe Pretty Madlala et al.   PLoS One

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

The Relation of Uric Acid to Brain Atrophy and Cognition: The Rotterdam Scan Study

(2013) Benjamin F.J. Verhaaren et al.   NEUROEPIDEMIOLOGY

Relationship between Uric Acid and Subtle Cognitive Dysfunction in Chronic Kidney Disease

(2011) Baris Afsar et al.   AMERICAN JOURNAL OF NEPHROLOGY