Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair

The Elusive 5′-Deoxyadenosyl Radical: Captured and Characterized by Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopies

(2019) Hao Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Irg1expression in myeloid cells prevents immunopathology duringM. tuberculosisinfection

(2018) Sharmila Nair et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Sacrificial Cobalt–Carbon Bond Homolysis in Coenzyme B12 as a Cofactor Conservation Strategy

(2018) Gregory C. Campanello et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

7-Carboxy-7-deazaguanine Synthase: A Radical S-Adenosyl-l-methionine Enzyme with Polar Tendencies

(2017) Nathan A. Bruender et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An editor for the generation and customization of geometry restraints

(2017) Nigel W. Moriarty et al.   Acta Crystallographica Section D-Structural Biology

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Characterization of a Cross-Linked Protein–Nucleic Acid Substrate Radical in the Reaction Catalyzed by RlmN

(2014) Alexey Silakov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bacterial itaconate degradation promotes pathogenicity

(2014) Jahminy Sasikaran et al.   Nature Chemical Biology

Vitamin B12 metabolism in Mycobacterium tuberculosis

(2013) Krishnamoorthy Gopinath et al.   Future Microbiology

Menaquinone Biosynthesis: Formation of Aminofutalosine Requires a Unique Radical SAM Enzyme

(2013) Nilkamal Mahanta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A vitamin B12 transporter in Mycobacterium tuberculosis

(2013) K. Gopinath et al.   Open Biology

Genetic Architecture of Vitamin B12 and Folate Levels Uncovered Applying Deeply Sequenced Large Datasets

(2013) Niels Grarup et al.   PLoS Genetics

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

1H NMR-based Metabolomic Profiling in Mice Infected withMycobacterium tuberculosis

(2011) Ji-Hyun Shin et al.   JOURNAL OF PROTEOME RESEARCH

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Oxidative decarboxylation of α-hydroxy acids by a functional model of the nonheme iron oxygenase, CloR

(2010) Tapan Kanti Paine et al.   CHEMICAL COMMUNICATIONS

Structures of the Human GTPase MMAA and Vitamin B12-dependent Methylmalonyl-CoA Mutase and Insight into Their Complex Formation

(2010) D. Sean Froese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optimisation of Bioluminescent Reporters for Use with Mycobacteria

(2010) Nuria Andreu et al.   PLoS One

electronic Ligand Builder and Optimization Workbench(eLBOW): a tool for ligand coordinate and restraint generation

(2009) Nigel W. Moriarty et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A G-protein editor gates coenzyme B12 loading and is corrupted in methylmalonic aciduria

(2009) D. Padovani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iterative-build OMIT maps: map improvement by iterative model building and refinement without model bias

(2008) Thomas C. Terwilliger et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

8,5′-Cyclopurine-2′-deoxynucleosides in DNA: Mechanisms of formation, measurement, repair and biological effects

(2008) Pawel Jaruga et al.   DNA REPAIR

Functional Characterization of a Vitamin B12-Dependent Methylmalonyl Pathway in Mycobacterium tuberculosis: Implications for Propionate Metabolism during Growth on Fatty Acids

(2008) S. Savvi et al.   JOURNAL OF BACTERIOLOGY

Adenosyltransferase tailors and delivers coenzyme B12

(2008) Dominique Padovani et al.   Nature Chemical Biology