Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia

Genetic Susceptibility Determines β-Cell Function and Fasting Glycemia Trajectories Throughout Childhood: A 12-Year Cohort Study (EarlyBird 76)

(2020) Jerome Carayol et al.   DIABETES CARE

Disruption of fasting and post-load glucose homeostasis are largely independent and sustained by distinct and early major beta-cell function defects: a cross-sectional and longitudinal analysis of the Relationship between Insulin Sensitivity and Cardiovascular risk (RISC) study cohort

(2020) Alessandro Mengozzi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Insulin resistance and insulin hypersecretion in the metabolic syndrome and type 2 diabetes: Time for a conceptual framework shift

(2019) Christopher J Nolan et al.   Diabetes & Vascular Disease Research

Epigenetics in Human Obesity and Type 2 Diabetes

(2019) Charlotte Ling et al.   Cell Metabolism

Effects of Treatment of Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes With Metformin Alone or in Combination With Insulin Glargine on β-Cell Function: Comparison of Responses In Youth And Adults

(2019)   DIABETES

Effect of Linagliptin vs Glimepiride on Major Adverse Cardiovascular Outcomes in Patients With Type 2 Diabetes

(2019) Julio Rosenstock et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: I. Observations Using the Hyperglycemic Clamp

(2018)   DIABETES CARE

Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: II. Observations Using the Oral Glucose Tolerance Test

(2018)   DIABETES CARE

Effects of Diazoxide-Mediated Insulin Suppression on Glucose and Lipid Metabolism in Nondiabetic Obese Men

(2018) Sandra Loves et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

(2018) Anubha Mahajan et al.   NATURE GENETICS

Mild Suppression of Hyperinsulinemia to Treat Obesity and Insulin Resistance

(2018) Melissa M. Page et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Mouse Model of Beta-Cell Dysfunction as Seen in Human Type 2 Diabetes

(2018) Jacqueline H. Parilla et al.   Journal of Diabetes Research

Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis

(2018) Miriam S. Udler et al.   PLOS MEDICINE

β-Cell Failure or β-Cell Abuse?

(2018) Karel Erion et al.   Frontiers in Endocrinology

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

(2018) Anubha Mahajan et al.   NATURE GENETICS

Dietary intake and risk of non-severe hypoglycemia in adolescents with type 1 diabetes

(2017) Victor W. Zhong et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

High fat feeding unmasks variable insulin responses in male C57BL/6 mouse substrains

(2017) Rebecca L Hull et al.   JOURNAL OF ENDOCRINOLOGY

A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice

(2016) Camille Attané et al.   DIABETOLOGIA

Discriminatory ability of simple OGTT-based beta cell function indices for prediction of prediabetes and type 2 diabetes: the CODAM study

(2016) Louise J. C. J. den Biggelaar et al.   DIABETOLOGIA

Hyper-Variability in Circulating Insulin, High Fat Feeding Outcomes, and Effects of Reducing Ins2 Dosage in Male Ins1-Null Mice in a Specific Pathogen-Free Facility

(2016) Nicole M. Templeman et al.   PLoS One

Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium

(2015) Danielle A. Fontaine et al.   DIABETES

Suppression of hyperinsulinaemia in growing female mice provides long-term protection against obesity

(2015) Nicole M. Templeman et al.   DIABETOLOGIA

Recent developments on the role of epigenetics in obesity and metabolic disease

(2015) Susan J. van Dijk et al.   Clinical Epigenetics

β-Cell Function, Incretin Effect, and Incretin Hormones in Obese Youth Along the Span of Glucose Tolerance From Normal to Prediabetes to Type 2 Diabetes

(2014) Sara F. Michaliszyn et al.   DIABETES

Very Low–Calorie Diet Mimics the Early Beneficial Effect of Roux-en-Y Gastric Bypass on Insulin Sensitivity and β-Cell Function in Type 2 Diabetic Patients

(2013) Clifton Jackness et al.   DIABETES

Prediction of Diabetes Based on Baseline Metabolic Characteristics in Individuals at High Risk

(2013) R. A. DeFronzo et al.   DIABETES CARE

Co-occurrence of Risk Alleles in or Near Genes Modulating Insulin Secretion Predisposes Obese Youth to Prediabetes

(2013) C. Giannini et al.   DIABETES CARE

Evidence of Reduced β-Cell Function in Asian Indians With Mild Dysglycemia

(2013) Lisa R. Staimez et al.   DIABETES CARE

Effects of Metformin, Metformin Plus Rosiglitazone, and Metformin Plus Lifestyle on Insulin Sensitivity and  -Cell Function in TODAY

(2013)   DIABETES CARE

Longitudinal changes in insulin sensitivity and beta cell function between women with and without a history of gestational diabetes mellitus

(2013) Anny H. Xiang et al.   DIABETOLOGIA

Evidence of early beta-cell deficiency among children who show impaired fasting glucose: 10-yr cohort study (EarlyBird 56)

(2013) Joanne Hosking et al.   PEDIATRIC DIABETES

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

Evidence for Early Defects in Insulin Sensitivity and Secretion Before the Onset of Glucose Dysregulation in Obese Youths: A Longitudinal Study

(2012) C. Giannini et al.   DIABETES

Diabetes: Have We Got It All Wrong?: Insulin hypersecretion and food additives: cause of obesity and diabetes?

(2012) B. E. Corkey   DIABETES CARE

Diabetes: Have We Got It All Wrong?: Hyperinsulinism as the culprit: surgery provides the evidence

(2012) W. J. Pories et al.   DIABETES CARE

A Clinical Trial to Maintain Glycemic Control in Youth with Type 2 Diabetes

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Progressive deterioration of β-cell function in obese youth with type 2 diabetes

(2012) Fida Bacha et al.   PEDIATRIC DIABETES

Effects of Rosiglitazone, Glyburide, and Metformin on  -Cell Function and Insulin Sensitivity in ADOPT

(2011) S. E. Kahn et al.   DIABETES

Banting Lecture 2011: Hyperinsulinemia: Cause or Consequence?

(2011) B. E. Corkey   DIABETES

Early and longer term effects of gastric bypass surgery on tissue-specific insulin sensitivity and beta cell function in morbidly obese patients with and without type 2 diabetes

(2011) S. Camastra et al.   DIABETOLOGIA

Roux-en-Y Gastric Bypass Corrects Hyperinsulinemia Implications for the Remission of Type 2 Diabetes

(2011) Melissa A. Reed et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pioglitazone for Diabetes Prevention in Impaired Glucose Tolerance

(2011) Ralph A. DeFronzo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Declining  -Cell Function Relative to Insulin Sensitivity With Increasing Fasting Glucose Levels in the Nondiabetic Range in Children

(2010) H. Tfayli et al.   DIABETES CARE

Changes in Insulin Sensitivity and Insulin Release in Relation to Glycemia and Glucose Tolerance in 6,414 Finnish Men

(2009) A. Stancakova et al.   DIABETES

Basal-State Hyperinsulinemia in Healthy Normoglycemic Adults Is Predictive of Type 2 Diabetes Over a 24-Year Follow-Up: A preliminary report

(2009) R. Dankner et al.   DIABETES CARE

Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study

(2009) Adam G Tabák et al.   LANCET

Oral Disposition Index Predicts the Development of Future Diabetes Above and Beyond Fasting and 2-h Glucose Levels

(2008) K. M. Utzschneider et al.   DIABETES CARE

Insulin Resistance and Hyperinsulinemia: Is hyperinsulinemia the cart or the horse?

(2008) M. H. Shanik et al.   DIABETES CARE