Excess cholesterol inhibits glucose-stimulated fusion pore dynamics in insulin exocytosis

Changes in beta cell function occur in prediabetes and early disease in the Lepr db mouse model of diabetes

(2016) Oanh H. Do et al.   DIABETOLOGIA

Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release

(2015) J Jackson et al.   MOLECULAR PSYCHIATRY

Cholesterol Accumulation Increases Insulin Granule Size and Impairs Membrane Trafficking

(2012) Jonathan S. Bogan et al.   TRAFFIC

Dual-mode of insulin action controls GLUT4 vesicle exocytosis

(2011) Yingke Xu et al.   JOURNAL OF CELL BIOLOGY

A new role for the dynamin GTPase in the regulation of fusion pore expansion

(2011) Arun Anantharam et al.   MOLECULAR BIOLOGY OF THE CELL

Cholesterol in β-cell Dysfunction: The Emerging Connection Between HDL Cholesterol and Type 2 Diabetes

(2010) Liam R. Brunham et al.   Current Diabetes Reports

Direct dynamin–actin interactions regulate the actin cytoskeleton

(2010) Changkyu Gu et al.   EMBO JOURNAL

An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic β cells

(2010) Jeffrey M. Sturek et al.   JOURNAL OF CLINICAL INVESTIGATION

Exocytosis of Post-Golgi Vesicles Is Regulated by Components of the Endocytic Machinery

(2009) Jyoti K. Jaiswal et al.   CELL

Cholesterol metabolism and pancreatic β-cell function

(2009) Michelle Fryirs et al.   CURRENT OPINION IN LIPIDOLOGY

Insulin Granule Recruitment and Exocytosis Is Dependent on p110  in Insulinoma and Human  -Cells

(2009) G. M. Pigeau et al.   DIABETES

Cholesterol Regulates Glucose-stimulated Insulin Secretion through Phosphatidylinositol 4,5-Bisphosphate

(2009) Mingming Hao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteins and cholesterol-rich domains

(2008) Richard M. Epand   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Inhibition of Cholesterol Biosynthesis Impairs Insulin Secretion and Voltage-Gated Calcium Channel Function in Pancreatic β-Cells

(2008) Fuzhen Xia et al.   ENDOCRINOLOGY

Kiss-and-run exocytosis and fusion pores of secretory vesicles in human β-cells

(2008) Salma T. Hanna et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY