Autophagy-dependent ferroptosis in cancer

CCT2 is an aggrephagy receptor for clearance of solid protein aggregates

(2022) Xinyu Ma et al.   CELL

Engineering dual catalytic nanomedicine for autophagy-augmented and ferroptosis-involved cancer nanotherapy

(2022) Zhifang Li et al.   BIOMATERIALS

A non-canonical vitamin K cycle is a potent ferroptosis suppressor

(2022) Eikan Mishima et al.   NATURE

Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity

(2022) Bartosz Wiernicki et al.   Nature Communications

NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron–Sulfur Cluster Proteins

(2022) Naiara Santana-Codina et al.   Cancer Discovery

Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells

(2022) Gilles Rademaker et al.   Redox Biology

A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis

(2022) Xin Chen et al.   Nature Communications

The dark side of ferroptosis in pancreatic cancer

(2021) Jiao Liu et al.   OncoImmunology

Broadening horizons: the role of ferroptosis in cancer

(2021) Xin Chen et al.   Nature Reviews Clinical Oncology

Mitophagy in Pancreatic Cancer

(2021) Yangchun Xie et al.   Frontiers in Oncology

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Ferritinophagy and ferroptosis in the management of metabolic diseases

(2021) Amir Ajoolabady et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

STING1 Promotes Ferroptosis Through MFN1/2-Dependent Mitochondrial Fusion

(2021) Changfeng Li et al.   Frontiers in Cell and Developmental Biology

STING1 in sepsis: Mechanisms, functions, and implications

(2021) Ruo-Xi Zhang et al.   Chinese Journal of Traumatology

Life after the Anthropocene

(2020) Michael Gross   CURRENT BIOLOGY

CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer

(2020) Haiyang Zhang et al.   Molecular Cancer

Acetylation of STX17 (syntaxin 17) controls autophagosome maturation

(2020) Qiuhong Shen et al.   Autophagy

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death

(2020) Changfeng Li et al.   Autophagy

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

(2020) Keisuke Yamamoto et al.   NATURE

BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains

(2020) Xiaoli Wu et al.   Autophagy

New insights regarding SNARE proteins in autophagosome-lysosome fusion

(2020) Xiaoyu Tian et al.   Autophagy

Atg8-mediated super-assembly of Atg40 induces local ER remodeling in reticulophagy

(2020) Keisuke Mochida et al.   Autophagy

Regulation and function of autophagy in pancreatic cancer

(2020) Jingbo Li et al.   Autophagy

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs

(2019) Åsa Birna Birgisdottir et al.   Autophagy

Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins

(2019) Martina Wirth et al.   Nature Communications

PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis

(2019) Chaojun Yan et al.   Autophagy

GABARAPs and LC3s have opposite roles in regulating ULK1 for autophagy induction

(2019) Douglas S. Grunwald et al.   Autophagy

A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation

(2019) Yixian Cui et al.   SCIENCE

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

FKBP8 LIRL‐dependent mitochondrial fragmentation facilitates mitophagy under stress conditions

(2019) Seung‐Min Yoo et al.   FASEB JOURNAL

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

(2018) Rui Kang et al.   Cell Host & Microbe

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

(2018) Matthew D. Smith et al.   DEVELOPMENTAL CELL

NUFIP1 is a ribosome receptor for starvation-induced ribophagy

(2018) Gregory A. Wyant et al.   SCIENCE

Iron and Cancer

(2018) Suzy V. Torti et al.   Annual Review of Nutrition

DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin

(2018) Jing Du et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Targeting iron metabolism in drug discovery and delivery

(2017) Bart J. Crielaard et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells

(2016) Renyu Lin et al.   CANCER LETTERS

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

(2016) Fiorenza Fumagalli et al.   NATURE CELL BIOLOGY

Toward an understanding of autophagosome-lysosome fusion: The unsuspected role of ATG14

(2015) Amélie Bernard et al.   Autophagy

The small GTPase Rab7 as a central regulator of hepatocellular lipophagy

(2015) Barbara Schroeder et al.   HEPATOLOGY

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

(2015) Jin-Mi Heo et al.   MOLECULAR CELL

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

ATM functions at the peroxisome to induce pexophagy in response to ROS

(2015) Jiangwei Zhang et al.   NATURE CELL BIOLOGY

Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy

(2015) Christina H. Eng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Posttranslational modification of autophagy-related proteins in macroautophagy

(2014) Yangchun Xie et al.   Autophagy

Autophagic Clearance of PolyQ Proteins Mediated by Ubiquitin-Atg8 Adaptors of the Conserved CUET Protein Family

(2014) Kefeng Lu et al.   CELL

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

DAMPs and autophagy

(2013) Qiuhong Zhang et al.   Autophagy

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

(2013) Ikuko Maejima et al.   EMBO JOURNAL

ATG7 deficiency suppresses apoptosis and cell death induced by lysosomal photodamage

(2012) David H. Kessel et al.   Autophagy

Hormesis: why it is important to biogerontologists

(2012) Edward J. Calabrese et al.   BIOGERONTOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

NBR1 acts as an autophagy receptor for peroxisomes

(2012) E. Deosaran et al.   JOURNAL OF CELL SCIENCE

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

HMGB1 as an autophagy sensor in oxidative stress

(2011) Rui Kang et al.   Autophagy

Autophagic degradation of active caspase-8

(2010) Wen Hou et al.   Autophagy

HMGB1 release and redox regulates autophagy and apoptosis in cancer cells

(2010) D Tang et al.   ONCOGENE

The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway

(2009) Y. T. Zheng et al.   JOURNAL OF IMMUNOLOGY

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE