CCT2 is an aggrephagy receptor for clearance of solid protein aggregates

Wetting regulates autophagy of phase-separated compartments and the cytosol

(2021) Jaime Agudo-Canalejo et al.   NATURE

Dynamic Monitoring of Phase-Separated Biomolecular Condensates by Photoluminescence Lifetime Imaging

(2021) Zihe Yan et al.   ANALYTICAL CHEMISTRY

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling

(2021) Susanne Zellner et al.   MOLECULAR CELL

Structural and functional dissection of reovirus capsid folding and assembly by the prefoldin-TRiC/CCT chaperone network

(2021) Jonathan J. Knowlton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A guide to the regulation of selective autophagy receptors

(2021) Andrea Gubas et al.   FEBS Journal

Spatiotemporal dynamic regulation of membraneless organelles by chaperone networks

(2021) Dan Li et al.   TRENDS IN CELL BIOLOGY

Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation

(2021) Eleonora Turco et al.   Nature Communications

Liquidity Is a Critical Determinant for Selective Autophagy of Protein Condensates

(2020) Akinori Yamasaki et al.   MOLECULAR CELL

ER-Phagy: Quality Control and Turnover of Endoplasmic Reticulum

(2020) Haruka Chino et al.   TRENDS IN CELL BIOLOGY

A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion

(2020) Min Zhang et al.   CELL

Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species

(2020) Eliana Nachman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liquid–Liquid Phase Separation and Its Mechanistic Role in Pathological Protein Aggregation

(2020) W. Michael Babinchak et al.   JOURNAL OF MOLECULAR BIOLOGY

Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation

(2020) Zhenying Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Liquid–liquid phase separation in autophagy

(2020) Nobuo N. Noda et al.   JOURNAL OF CELL BIOLOGY

α-Synuclein aggregation nucleates through liquid–liquid phase separation

(2020) Soumik Ray et al.   Nature Chemistry

TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes

(2020) Lisa Wetzel et al.   Nature Communications

Beyond aggregation: Pathological phase transitions in neurodegenerative disease

(2020) Cécile Mathieu et al.   SCIENCE

Fyn Kinase Controls Tau Aggregation In Vivo

(2020) Adam Briner et al.   Cell Reports

Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain

(2020) Shireen A. Sarraf et al.   MOLECULAR CELL

Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles

(2020) Jinge Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story

(2019) Daniel Gestaut et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress

(2019) Heeseon An et al.   MOLECULAR CELL

Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins

(2019) Jian Xiao et al.   Science China-Life Sciences

Propagation of Protein Aggregation in Neurodegenerative Diseases

(2019) Jaime Vaquer-Alicea et al.   Annual Review of Biochemistry

Phase Separation in Regulation of Aggrephagy

(2019) Daxiao Sun et al.   JOURNAL OF MOLECULAR BIOLOGY

Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors

(2019) Terje Johansen et al.   JOURNAL OF MOLECULAR BIOLOGY

Liquid–Liquid Phase Separation in Disease

(2019) Simon Alberti et al.   Annual Review of Genetics

Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

(2019) Zhaoyang Li et al.   NATURE

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation

(2018) Mario Hofweber et al.   CELL

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

(2018) Seema Qamar et al.   CELL

Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation

(2018) Daxiao Sun et al.   CELL RESEARCH

p62 filaments capture and present ubiquitinated cargos for autophagy

(2018) Gabriele Zaffagnini et al.   EMBO JOURNAL

Tau protein liquid–liquid phase separation can initiate tau aggregation

(2018) Susanne Wegmann et al.   EMBO JOURNAL

Cargo recognition and degradation by selective autophagy

(2018) Damián Gatica et al.   NATURE CELL BIOLOGY

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR Regulates Phase Separation of PGL Granules to Modulate Their Autophagic Degradation

(2018) Gangming Zhang et al.   CELL

Selective autophagy as a potential therapeutic target for neurodegenerative disorders

(2018) Aurora Scrivo et al.   LANCET NEUROLOGY

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Protein misfolding specifies recruitment to cytoplasmic inclusion bodies

(2016) Kirill Bersuker et al.   JOURNAL OF CELL BIOLOGY

Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors

(2016) Yujin E. Kim et al.   MOLECULAR CELL

Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM

(2016) Yunxiang Zang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan

(2016) Alireza Noormohammadi et al.   Nature Communications

CCT complex restricts neuropathogenic protein aggregation via autophagy

(2016) Mariana Pavel et al.   Nature Communications

Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM

(2016) Yunxiang Zang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Global Analysis of Cellular Protein Flux Quantifies the Selectivity of Basal Autophagy

(2016) Tian Zhang et al.   Cell Reports

CCT2 Mutations Evoke Leber Congenital Amaurosis due to Chaperone Complex Instability

(2016) Yuriko Minegishi et al.   Scientific Reports

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

The Mechanism and Function of Group II Chaperonins

(2015) Tom Lopez et al.   JOURNAL OF MOLECULAR BIOLOGY

Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils

(2015) Xuechao Gao et al.   MOLECULAR CELL

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

(2015) Keisuke Mochida et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A

(2015) Pui-Mun Wong et al.   Nature Communications

Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion

(2015) Min Zhang et al.   eLife

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Autophagy-independent incorporation of GFP-LC3 into protein aggregates is dependent on its interaction with p62/SQSTM1

(2014) Elena Shvets et al.   Autophagy

Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controls

(2014) Isei Tanida et al.   Autophagy

Cycloheximide inhibits starvation-induced autophagy through mTORC1 activation

(2014) Takako Watanabe-Asano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagic Clearance of PolyQ Proteins Mediated by Ubiquitin-Atg8 Adaptors of the Conserved CUET Protein Family

(2014) Kefeng Lu et al.   CELL

Receptor-mediated mitophagy in yeast and mammalian systems

(2014) Lei Liu et al.   CELL RESEARCH

Mechanisms of protein-folding diseases at a glance

(2014) J. S. Valastyan et al.   Disease Models & Mechanisms

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

(2014) Marc Brehme et al.   Cell Reports

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

The scaffold protein EPG-7 links cargo–receptor complexes with the autophagic assembly machinery

(2013) Long Lin et al.   JOURNAL OF CELL BIOLOGY

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding

(2013) G. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRiC’s tricks inhibit huntingtin aggregation

(2013) Sarah H Shahmoradian et al.   eLife

The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis

(2013) Liang Ge et al.   eLife

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Proteome folding and aggregation

(2012) Michele Vendruscolo   CURRENT OPINION IN STRUCTURAL BIOLOGY

Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy

(2012) Rita A. Hanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

(2012) J. Korac et al.   JOURNAL OF CELL SCIENCE

Identification of Autophagosome-associated Proteins and Regulators by Quantitative Proteomic Analysis and Genetic Screens

(2012) Jörn Dengjel et al.   MOLECULAR & CELLULAR PROTEOMICS

Consequences of oxidative stress in age-related macular degeneration

(2012) Stuart G. Jarrett et al.   MOLECULAR ASPECTS OF MEDICINE

LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy

(2012) Natalia von Muhlinen et al.   MOLECULAR CELL

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

The Role of Chaperone-Mediated Autophagy in Huntingtin Degradation

(2012) Lin Qi et al.   PLoS One

Function and Molecular Mechanism of Acetylation in Autophagy Regulation

(2012) C. Yi et al.   SCIENCE

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Intracellular Tau Aggregation Is Promoted by  -Synuclein Seeds and Provides Novel Insights into the Hyperphosphorylation of Tau

(2011) E. A. Waxman et al.   JOURNAL OF NEUROSCIENCE

The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy

(2010) Maria Filimonenko et al.   MOLECULAR CELL

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

SEPA-1 Mediates the Specific Recognition and Degradation of P Granule Components by Autophagy in C. elegans

(2009) Yuxia Zhang et al.   CELL

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles

(2009) A. J. Schindler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential Action of ATP-dependent Subunit Conformational Change and Interaction between Helical Protrusions in the Closure of the Built-in Lid of Group II Chaperonins

(2008) Taro Kanzaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies

(2008) Alice Y Yam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY