New insights regarding SNARE proteins in autophagosome-lysosome fusion

Acetylation of STX17 (syntaxin 17) controls autophagosome maturation

(2020) Qiuhong Shen et al.   Autophagy

Quantitative analysis of interactive behavior of mitochondria and lysosomes using structured illumination microscopy

(2020) Qixin Chen et al.   BIOMATERIALS

A VPS33A-binding motif on syntaxin17 controls autophagy completion in mammalian cells

(2019) Rebecca S Saleeb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation

(2019) Suresh Kumar et al.   DEVELOPMENTAL CELL

ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy

(2019) Qingzhou Chen et al.   CURRENT BIOLOGY

Sigma-1 receptor ablation impairs autophagosome clearance

(2019) Huan Yang et al.   Autophagy

RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells

(2019) Xianming Ding et al.   Autophagy

TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress

(2019) Heeseon An et al.   MOLECULAR CELL

DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B

(2019) Xiaoyu Tian et al.   Autophagy

STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism

(2019) Hongxu Xian et al.   Nature Communications

BAP31 Inhibits Cell Adaptation to ER Stress Conditions, Negatively Regulating Autophagy Induction by Interaction with STX17

(2019) Kayo Machihara et al.   Cells

Syntaxin-17-Dependent Mitochondrial Dynamics is Essential for Protection Against Oxidative-Stress-Induced Apoptosis

(2019) Wang et al.   Antioxidants

Silencing DAPK3 blocks the autophagosome-lysosome fusion by mediating SNAP29 in trophoblast cells under high glucose treatment

(2019) Yanling Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling

(2018) Pengli Zheng et al.   CELL RESEARCH

MAP1B‐LC1 prevents autophagosome formation by linking syntaxin 17 to microtubules

(2018) Kohei Arasaki et al.   EMBO REPORTS

Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17

(2018) Takahide Matsui et al.   JOURNAL OF CELL BIOLOGY

Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins

(2018) Suresh Kumar et al.   JOURNAL OF CELL BIOLOGY

Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 3

(2018) Hana Kimura et al.   JOURNAL OF LIPID RESEARCH

The IAP family member BRUCE regulates autophagosome–lysosome fusion

(2018) Petra Ebner et al.   Nature Communications

Non-canonical role of the SNARE protein Ykt6 in autophagosome-lysosome fusion

(2018) Szabolcs Takáts et al.   PLoS Genetics

Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy

(2018) Masashi Sugo et al.   EMBO JOURNAL

ER‐to‐lysosome‐associated degradation of proteasome‐resistant ATZ polymers occurs via receptor‐mediated vesicular transport

(2018) Ilaria Fregno et al.   EMBO JOURNAL

A novel in vitro assay reveals SNARE topology and the role of Ykt6 in autophagosome fusion with vacuoles

(2018) Jieqiong Gao et al.   JOURNAL OF CELL BIOLOGY

Reconstitution reveals Ykt6 as the autophagosomal SNARE in autophagosome–vacuole fusion

(2018) Levent Bas et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy

(2018) Chenyao Wang et al.   Nature Communications

Autophagosome maturation: An epic journey from the ER to lysosomes

(2018) Yan G. Zhao et al.   JOURNAL OF CELL BIOLOGY

Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17

(2017) Xiawei Cheng et al.   MOLECULAR CELL

Synaptic weight set by Munc13-1 supramolecular assemblies

(2017) Hirokazu Sakamoto et al.   NATURE NEUROSCIENCE

SNARE priming is essential for maturation of autophagosomes but not for their formation

(2017) Adi Abada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

SNARE zippering

(2016) X. Lou et al.   BIOSCIENCE REPORTS

VAMP7 Regulates Autophagy to Maintain Mitochondrial Homeostasis and to Control Insulin Secretion in Pancreatic β-Cells

(2016) Kyota Aoyagi et al.   DIABETES

An essential step of kinetochore formation controlled by the SNARE protein Snap29

(2016) Elena Morelli et al.   EMBO JOURNAL

Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion

(2016) Seth Malmersjö et al.   EMBO JOURNAL

Autophagosome–lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome

(2016) Junya Hasegawa et al.   EMBO JOURNAL

Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation

(2016) Thanh Ngoc Nguyen et al.   JOURNAL OF CELL BIOLOGY

Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system

(2016) Gian-Luca McLelland et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy

(2016) Shun-ichi Yamashita et al.   JOURNAL OF CELL BIOLOGY

The Vici Syndrome Protein EPG5 Is a Rab7 Effector that Determines the Fusion Specificity of Autophagosomes with Late Endosomes/Lysosomes

(2016) Zheng Wang et al.   MOLECULAR CELL

The ATG conjugation systems are important for degradation of the inner autophagosomal membrane

(2016) Kotaro Tsuboyama et al.   SCIENCE

LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes

(2016) Virginie Hubert et al.   Biology Open

A Role for the Ancient SNARE Syntaxin 17 in Regulating Mitochondrial Division

(2015) Kohei Arasaki et al.   DEVELOPMENTAL CELL

Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion

(2015) S. Jean et al.   EMBO REPORTS

Structure and function of longin SNAREs

(2015) F. Daste et al.   JOURNAL OF CELL SCIENCE

PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins

(2015) David G. McEwan et al.   MOLECULAR CELL

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

(2015) Jiajie Diao et al.   NATURE

GABARAPs regulate PI4P-dependent autophagosome:lysosome fusion

(2015) Hanzhi Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation inDrosophila

(2015) Elena Morelli et al.   Autophagy

Role of VAMP3 and VAMP7 in the commitment ofYersinia pseudotuberculosisto LC3-associated pathways involving single- or double-membrane vacuoles

(2014) Laure-Anne Ligeon et al.   Autophagy

The protein-vesicle network of autophagy

(2014) Liang Ge et al.   CURRENT OPINION IN CELL BIOLOGY

The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17

(2014) Peidu Jiang et al.   MOLECULAR BIOLOGY OF THE CELL

Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila

(2014) Szabolcs Takáts et al.   MOLECULAR BIOLOGY OF THE CELL

O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation

(2014) Bin Guo et al.   NATURE CELL BIOLOGY

SM proteins Sly1 and Vps33 co-assemble with Sec17 and SNARE complexes to oppose SNARE disassembly by Sec18

(2014) Braden T Lobingier et al.   eLife

Autophagy

(2013) Amber N. Hale et al.   Autophagy

Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function inDrosophila

(2013) Szabolcs Takáts et al.   JOURNAL OF CELL BIOLOGY

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

Dual roles of Atg8−PE deconjugation by Atg4 in autophagy

(2012) Zhong-Qiu Yu et al.   Autophagy

Tyrosine phosphorylation of a SNARE protein, Syntaxin 17: Implications for membrane trafficking in the early secretory pathway

(2012) Madhavi Muppirala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Phosphatidylinositol-3-Phosphate Clearance Plays a Key Role in Autophagosome Completion

(2012) Eduardo Cebollero et al.   CURRENT BIOLOGY

Structural Basis of the Intracellular Sorting of the SNARE VAMP7 by the AP3 Adaptor Complex

(2012) Helen M. Kent et al.   DEVELOPMENTAL CELL

Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome

(2012) David A. Tumbarello et al.   NATURE CELL BIOLOGY

The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation

(2012) Ingmar B Schäfer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reconstitution of Mitochondria Derived Vesicle Formation Demonstrates Selective Enrichment of Oxidized Cargo

(2012) Vincent Soubannier et al.   PLoS One

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi

(2011) Madhavi Muppirala et al.   BIOLOGY OF THE CELL

SNARE Proteins Are Required for Macroautophagy

(2011) Usha Nair et al.   CELL

Autophagosome Precursor Maturation Requires Homotypic Fusion

(2011) Kevin Moreau et al.   CELL

OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation

(2011) Takashi Itoh et al.   JOURNAL OF CELL BIOLOGY

Lysosomal positioning coordinates cellular nutrient responses

(2011) Viktor I. Korolchuk et al.   NATURE CELL BIOLOGY

The Longin SNARE VAMP7/TI-VAMP Adopts a Closed Conformation

(2010) Sandro Vivona et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy

(2009) Isabelle Vergne et al.   EMBO JOURNAL

Depletion of Kinesin 5B Affects Lysosomal Distribution and Stability and Induces Peri-Nuclear Accumulation of Autophagosomes in Cancer Cells

(2009) Carla M. P. Cardoso et al.   PLoS One

Molecular Basis for the Sorting of the SNARE VAMP7 into Endocytic Clathrin-Coated Vesicles by the ArfGAP Hrb

(2008) Paul R. Pryor et al.   CELL

Dynein-dependent Movement of Autophagosomes Mediates Efficient Encounters with Lysosomes

(2008) Shunsuke Kimura et al.   CELL STRUCTURE AND FUNCTION