Glycogen metabolism has a key role in the cancer microenvironment and provides new targets for cancer therapy

Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency

(2016) Benjamin L. Farah et al.   JOURNAL OF HEPATOLOGY

Loss of Protein Targeting to Glycogen sensitizes human hepatocellular carcinoma cells towards glucose deprivation mediated oxidative stress and cell death

(2015) Rongqiang Yang et al.   BIOSCIENCE REPORTS

Sodium valproate increases the brain isoform of glycogen phosphorylase: looking for a compensation mechanism in McArdle disease using a mouse primary skeletal-muscle culture in vitro

(2015) N. de Luna et al.   Disease Models & Mechanisms

Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design

(2015) D. Sean Froese et al.   HUMAN MOLECULAR GENETICS

Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells

(2015) H Bhanot et al.   LEUKEMIA

Getting a handle on glycogen synthase – Its interaction with glycogenin

(2015) Elton Zeqiraj et al.   MOLECULAR ASPECTS OF MEDICINE

Polyglucosan storage myopathies

(2015) Carola Hedberg-Oldfors et al.   MOLECULAR ASPECTS OF MEDICINE

Brain glycogen in health and disease

(2015) Jordi Duran et al.   MOLECULAR ASPECTS OF MEDICINE

Role of glycogen phosphorylase in liver glycogen metabolism

(2015) Loranne Agius   MOLECULAR ASPECTS OF MEDICINE

Targeting glycogen metabolism in bladder cancer

(2015) Carolyn Ritterson Lew et al.   Nature Reviews Urology

Glycogen-rich clear cell carcinoma of the breast showing carcinomatous lymphangiosis and extremely aggressive clinical behavior

(2015) Ayaka Sato et al.   PATHOLOGY INTERNATIONAL

Radiation-Induced Glycogen Accumulation Detected by Single Cell Raman Spectroscopy Is Associated with Radioresistance that Can Be Reversed by Metformin

(2015) Quinn Matthews et al.   PLoS One

KIAA1199 interacts with glycogen phosphorylase kinase β-subunit (PHKB) to promote glycogen breakdown and cancer cell survival

(2015) Masato Terashima et al.   Oncotarget

Neuronal glycogen synthesis contributes to physiological aging

(2014) Christopher Sinadinos et al.   AGING CELL

A new muscle glycogen storage disease associated with glycogenin-1 deficiency

(2014) Edoardo Malfatti et al.   ANNALS OF NEUROLOGY

Glycogen metabolism in cancer

(2014) Christos E. Zois et al.   BIOCHEMICAL PHARMACOLOGY

Phylogenomic analysis of glycogen branching and debranching enzymatic duo

(2014) Christian M Zmasek et al.   BMC EVOLUTIONARY BIOLOGY

A Novel Radiotracer to Image Glycogen Metabolism in Tumors by Positron Emission Tomography

(2014) T. H. Witney et al.   CANCER RESEARCH

Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain

(2014) J. Chen et al.   CANCER RESEARCH

Neurons Have an Active Glycogen Metabolism that Contributes to Tolerance to Hypoxia

(2014) Isabel Saez et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Role in Tumor Growth of a Glycogen Debranching Enzyme Lost in Glycogen Storage Disease

(2014) Sunny Guin et al.   JNCI-Journal of the National Cancer Institute

Glucose-6–phosphatase Is a Key Metabolic Regulator of Glioblastoma Invasion

(2014) Sara Abbadi et al.   MOLECULAR CANCER RESEARCH

Increased sensitivity to glucose starvation correlates with downregulation of glycogen phosphorylase isoform PYGB in tumor cell lines resistant to 2-deoxy-d-glucose

(2013) Katherine B. Philips et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Glycogen phosphorylase inhibitors: a patent review (2008 – 2012)

(2013) Nicolas Gaboriaud-Kolar et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Muscle glycogen stores and fatigue

(2013) Niels Ørtenblad et al.   JOURNAL OF PHYSIOLOGY-LONDON

Laforin–Malin Complex Degrades Polyglucosan Bodies in Concert with Glycogen Debranching Enzyme and Brain Isoform Glycogen Phosphorylase

(2013) Yan Liu et al.   MOLECULAR NEUROBIOLOGY

An Optimized Histochemical Method to Assess Skeletal Muscle Glycogen and Lipid Stores Reveals Two Metabolically Distinct Populations of Type I Muscle Fibers

(2013) Clara Prats et al.   PLoS One

Metabolic signatures of amyotrophic lateral sclerosis reveal insights into disease pathogenesis

(2013) J. C. Dodge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multifunctional role of astrocytes as gatekeepers of neuronal energy supply

(2013) Jillian L. Stobart et al.   Frontiers in Cellular Neuroscience

Role of Autophagy in Glycogen Breakdown and Its Relevance to Chloroquine Myopathy

(2013) Jonathan Zirin et al.   PLOS BIOLOGY

Glycogen and its metabolism: some new developments and old themes

(2012) Peter J. Roach et al.   BIOCHEMICAL JOURNAL

Glucose Utilization via Glycogen Phosphorylase Sustains Proliferation and Prevents Premature Senescence in Cancer Cells

(2012) Elena Favaro et al.   Cell Metabolism

Acetylation Negatively Regulates Glycogen Phosphorylase by Recruiting Protein Phosphatase 1

(2012) Tengfei Zhang et al.   Cell Metabolism

Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress

(2012) Kwai Wa Cheng et al.   EMBO Molecular Medicine

Sodium tungstate activates glycogen synthesis through a non-canonical mechanism involving G-proteins

(2012) Delia Zafra et al.   FEBS LETTERS

Formation of New High Density Glycogen-Microtubule Structures Is Induced by Cardiac Steroids

(2012) Eleonora Fridman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent Advances in the Allosteric Inhibition of Glycogen Phosphorylase

(2012) W. A. Loughlin   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Physiological Control of Liver Glycogen Metabolism: Lessons from Novel Glycogen Phosphorylase Inhibitors

(2012) L. Agius   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Glucose Induces Protein Targeting to Glycogen in Hepatocytes by Fructose 2,6-Bisphosphate-Mediated Recruitment of MondoA to the Promoter

(2012) J. L. Petrie et al.   MOLECULAR AND CELLULAR BIOLOGY

How cancer metabolism is tuned for proliferation and vulnerable to disruption

(2012) Almut Schulze et al.   NATURE

Glycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell Survival

(2012) Joffrey Pelletier et al.   Frontiers in Oncology

Autophagy in Lysosomal Myopathies

(2011) May Christine V. Malicdan et al.   BRAIN PATHOLOGY

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Fasting-Induced Protein Phosphatase 1 Regulatory Subunit Contributes to Postprandial Blood Glucose Homeostasis via Regulation of Hepatic Glycogenesis

(2011) X. Luo et al.   DIABETES

Increased glucose concentration results in reduced proteasomal activity and the formation of glycogen positive aggresomal structures

(2011) Rajat Puri et al.   FEBS Journal

Generation of a novel mouse model that recapitulates early and adult onset glycogenosis type IV

(2011) H. Orhan Akman et al.   HUMAN MOLECULAR GENETICS

R3F, a novel membrane-associated glycogen targeting subunit of protein phosphatase 1 regulates glycogen synthase in astrocytoma cells in response to glucose and extracellular signals

(2011) Ian R. Kelsall et al.   JOURNAL OF NEUROCHEMISTRY

Natural History of Hepatocellular Adenoma Formation in Glycogen Storage Disease Type I

(2011) David Q. Wang et al.   JOURNAL OF PEDIATRICS

Brain glycogen supercompensation following exhaustive exercise

(2011) Takashi Matsui et al.   JOURNAL OF PHYSIOLOGY-LONDON

Misdiagnosis of clear cell renal cell carcinoma

(2011) Vladimir A. Valera et al.   Nature Reviews Urology

Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish

(2011) S Camus et al.   ONCOGENE

Astrocyte–neuron metabolic relationships: for better and for worse

(2011) Igor Allaman et al.   TRENDS IN NEUROSCIENCES

Glycogen Storage Diseases: A Brief Review and Update on Clinical Features, Genetic Abnormalities, Pathologic Features, and Treatment

(2011) John Hicks et al.   ULTRASTRUCTURAL PATHOLOGY

The regulation of muscle glycogen: the granule and its proteins

(2010) T. E. Graham et al.   Acta Physiologica

Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder—murine Pompe disease

(2010) Nina Raben et al.   Autophagy

Treatment of kidney cancer

(2010) William G. Kaelin   CANCER

Understanding the "lethal" drivers of tumor-stroma co-evolution

(2010) Michael P. Lisanti et al.   CANCER BIOLOGY & THERAPY

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Allosteric Regulation of Glycogen Synthase Controls Glycogen Synthesis in Muscle

(2010) Michale Bouskila et al.   Cell Metabolism

Brain glycogen and neurotransmitter levels in fast and slow methionine sulfoximine-selected mice

(2010) Jean-François Cloix et al.   EXPERIMENTAL NEUROLOGY

Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia

(2010) Guo-Min Shen et al.   FEBS LETTERS

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Glycogen synthesis in brain and astrocytes is inhibited by chronic lithium treatment

(2010) Andréa de Almeida Souza et al.   NEUROSCIENCE LETTERS

Hypoxia Promotes Glycogen Accumulation through Hypoxia Inducible Factor (HIF)-Mediated Induction of Glycogen Synthase 1

(2010) Nuria Pescador et al.   PLoS One

Structural basis for glucose-6-phosphate activation of glycogen synthase

(2010) Sulochanadevi Baskaran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct mutations in the glycogen debranching enzyme found in glycogen storage disease type III lead to impairment in diverse cellular functions

(2009) Alan Cheng et al.   HUMAN MOLECULAR GENETICS

Differential Regulation of Glycogenolysis by Mutant Protein Phosphatase-1 Glycogen-targeting Subunits

(2009) Arpad M. Danos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of Liver Glycogen Synthase Activity and Intracellular Distribution by Phosphorylation

(2009) Susana Ros et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temporal Neuropathologic and Behavioral Phenotype of 6neo/6neoPompe Disease Mice

(2009) Richard L. Sidman et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Distinct effects of subcellular glycogen localization on tetanic relaxation time and endurance in mechanically skinned rat skeletal muscle fibres

(2009) J. Nielsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of muscle glycogen synthase phosphorylation and kinetic properties by insulin, exercise, adrenaline and role in insulin resistance

(2009) Jørgen Jensen et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

New Inhibitors of Glycogen Phosphorylase as Potential Antidiabetic Agents

(2008) L. Somsak et al.   CURRENT MEDICINAL CHEMISTRY

Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease

(2008) N. Raben et al.   HUMAN MOLECULAR GENETICS

Lysosomal myopathies: An excessive build-up in autophagosomes is too much to handle

(2008) May Christine Malicdan et al.   NEUROMUSCULAR DISORDERS