Glycogen phosphorylase inhibitors: a patent review (2008 – 2012)

Glycogen and its metabolism: some new developments and old themes

(2012) Peter J. Roach et al.   BIOCHEMICAL JOURNAL

N-(4-Substituted-benzoyl)-N′-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods

(2012) Veronika Nagy et al.   BIOORGANIC & MEDICINAL CHEMISTRY

C-Glucosylated malonitrile as a key intermediate towards carbohydrate-based glycogen phosphorylase inhibitors

(2012) Sophie Feuillastre et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of heterocyclic N-(β-d-glucopyranosyl)carboxamides for inhibition of glycogen phosphorylase

(2012) Bálint Kónya et al.   CARBOHYDRATE RESEARCH

Glucose Utilization via Glycogen Phosphorylase Sustains Proliferation and Prevents Premature Senescence in Cancer Cells

(2012) Elena Favaro et al.   Cell Metabolism

Linking Glycogen and Senescence in Cancer Cells

(2012) Susana Ros et al.   Cell Metabolism

Design, synthesis and biological evaluation of thiazole- and indole-based derivatives for the treatment of type II diabetes

(2012) Qinyuan Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Binding Evaluation of Fragment-Based Scaffolds for Probing Allosteric Enzymes

(2012) Isabelle Krimm et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Prototype of Glycogen Phosphorylase

(2012) E. D.Chrysina   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Synthesis of N-Glucopyranosidic Derivatives as Potential Inhibitors that Bind at the Catalytic Site of Glycogen Phosphorylase

(2012) T. Gimisis   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Recent Advances in the Allosteric Inhibition of Glycogen Phosphorylase

(2012) W. A. Loughlin   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Computation as a Tool for Glycogen Phosphorylase Inhibitor Design

(2012) Joseph M. Hayes et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

GPR119 Modulators for the Treatment of Diabetes, Obesity, and Related Diseases

(2012) Ahmed F. Abdel-Magid   ACS Medicinal Chemistry Letters

From Structure – Based to Knowledge – Based Drug Design Through X-Ray Protein Crystallography: Sketching Glycogen Phosphorylase Binding Sites

(2011) E. D. Chrysina et al.   CURRENT MEDICINAL CHEMISTRY

Defective Glycogenesis Contributes Toward the Inability to Suppress Hepatic Glucose Production in Response to Hyperglycemia and Hyperinsulinemia in Zucker Diabetic Fatty Rats

(2011) T. P. Torres et al.   DIABETES

Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies

(2011) Zhongjie Liang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Impact of a Glycogen Phosphorylase Inhibitor and Metformin on Basal and Glucagon-Stimulated Hepatic Glucose Flux in Conscious Dogs

(2011) T. P. Torres et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Small molecules from natural sources, targeting signaling pathways in diabetes

(2010) Qiong Liu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The binding of β-d-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: A new class of inhibitors

(2010) Kyra-Melinda Alexacou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

1-(3-Deoxy-3-fluoro-β-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies

(2010) Vicky G. Tsirkone et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of Oleanolic Acid Dimers as Inhibitors of Glycogen Phosphorylase

(2010) Keguang Cheng et al.   CHEMISTRY & BIODIVERSITY

Glucose derived inhibitors of glycogen phosphorylase

(2010) László Somsák   COMPTES RENDUS CHIMIE

Novel therapeutics based on inhibiting the interaction of glycogen phosphorylase and GL-subunit of glycogen-associated protein phosphatase 1: WO2009127723

(2010) Lei Zhang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Prolonged Inhibition of Glycogen Phosphorylase in Livers of Zucker Diabetic Fatty Rats Models Human Glycogen Storage Diseases

(2010) Eike Floettmann et al.   TOXICOLOGIC PATHOLOGY

Glycogen Phosphorylase a Inhibitors with a Phenethylphenylphthalimide Skeleton Derived from Thalidomide-Related α-Glucosidase Inhibitors and Liver X Receptor Antagonists

(2009) Kazunori Motoshima et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Synthesis and structure–activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase

(2009) Marietta Tóth et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase

(2009) Lei Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of 1-(d-glucopyranosyl)-1,2,3-triazoles and their evaluation as glycogen phosphorylase inhibitors

(2009) Éva Bokor et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Terpenoids. III: Synthesis and biological evaluation of 23-hydroxybetulinic acid derivatives as novel inhibitors of glycogen phosphorylase

(2009) Peiqing Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes

(2008) Darya Zibrova et al.   BIOCHEMICAL JOURNAL

Synthesis and pharmacological evaluation of bis-3-(3,4-dichlorophenyl)acrylamide derivatives as glycogen phosphorylase inhibitors

(2008) Kenichi Onda et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Evaluation of novel Hyphodermin derivatives as Glycogen Phosphorylase a inhibitors

(2008) Wendy A. Loughlin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of 5-chloro-N-aryl-1H-indole-2-carboxamide derivatives as inhibitors of human liver glycogen phosphorylase a

(2008) Kenichi Onda et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, and pharmacological evaluation of N-bicyclo-5-chloro-1H-indole-2-carboxamide derivatives as potent glycogen phosphorylase inhibitors

(2008) Kenichi Onda et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of a C-glucosylated cyclopropylamide and evaluation as a glycogen phosphorylase inhibitor

(2008) Philippe Bertus et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Amino acid anthranilamide derivatives as a new class of glycogen phosphorylase inhibitors

(2008) Karen A. Evans et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy

(2008) Stephen A. Thomson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of Type 2 diabetes: 2. Optimization of serine and threonine ether amino acid residues

(2008) Steven M. Sparks et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes: 1. Identification of 1-amino-1-cycloalkyl carboxylic acid headgroups

(2008) Steven M. Sparks et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Biological Evaluation of Novel Pyrazolo[4,3-b]oleanane Derivatives as Inhibitors of Glycogen Phosphorylase

(2008) Jun Chen et al.   CHEMISTRY & BIODIVERSITY

New Inhibitors of Glycogen Phosphorylase as Potential Antidiabetic Agents

(2008) L. Somsak et al.   CURRENT MEDICINAL CHEMISTRY

Structure−Activity Relationships of Flavonoids as Potential Inhibitors of Glycogen Phosphorylase

(2008) Atsushi Kato et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Molecular Recognition of the Protein Phosphatase 1 Glycogen Targeting Subunit by Glycogen Phosphorylase

(2008) Alexander Pautsch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure−Activity Relationships, and X-ray Crystallographic Studies†

(2008) Xiaoan Wen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Practical Synthesis of Bredemolic Acid, a Natural Inhibitor of Glycogen Phosphorylase

(2008) Keguang Cheng et al.   JOURNAL OF NATURAL PRODUCTS

A Norsesquiterpene Lactone and a Benzoic Acid Derivative from the Leaves of Cyclocarya paliurus and their Glucosidase and Glycogen Phosphorylase Inhibiting Activities

(2008) Jun Li et al.   PLANTA MEDICA