A Charcot-Marie-Tooth-Causing Mutation in HSPB1 Decreases Cell Adaptation to Repeated Stress by Disrupting Autophagic Clearance of Misfolded Proteins

From Negative to Positive Diagnosis: Structural Variation Could Be the Second Mutation You Are Looking for in a Recessive Autosomal Gene

(2022) Ioanna Pyromali et al.   Journal of Personalized Medicine

Insights Into the Role of Heat Shock Protein 27 in the Development of Neurodegeneration

(2022) Bianka A. Holguin et al.   Frontiers in Molecular Neuroscience

Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities

(2021) Marlene F. Schmidt et al.   CELL DEATH AND DIFFERENTIATION

A weakened interface in the P182L variant of HSP27 associated with severe Charcot‐Marie‐Tooth neuropathy causes aberrant binding to interacting proteins

(2021) T Reid Alderson et al.   EMBO JOURNAL

HSPB1 Is Essential for Inducing Resistance to Proteotoxic Stress in Beta-Cells

(2021) Vinícius M. Gomes et al.   Cells

The Cytotoxicity and Clearance of Mutant Huntingtin and Other Misfolded Proteins

(2021) Austin Folger et al.   Cells

HDAC6 inhibitors: Translating genetic and molecular insights into a therapy for axonal CMT

(2020) Elisabeth Rossaert et al.   BRAIN RESEARCH

Small heat shock proteins in neurodegenerative diseases

(2020) Leen Vendredy et al.   CELL STRESS & CHAPERONES

The dual functions of α-tubulin acetylation in cellular apoptosis and autophage induced by tanespimycin in lung cancer cells

(2020) Qilin Wang et al.   Cancer Cell International

A novel HSPB1 mutation associated with a late onset CMT2 phenotype: Case presentation and systematic review of the literature

(2020) Arens Taga et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies

(2019) Mansour Haidar et al.   Autophagy

Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy

(2019) Dorsch et al.   Cells

Axonal transport and neurological disease

(2019) James N. Sleigh et al.   Nature Reviews Neurology

Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease

(2019) Jack M. Webster et al.   Frontiers in Pharmacology

Neuronal autophagy and axon degeneration

(2018) Yu Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Characterization of human small heat shock protein HSPB1 α-crystallin domain localized mutants associated with hereditary motor neuron diseases

(2018) Stephen D. Weeks et al.   Scientific Reports

Mitochondrial deficits and abnormal mitochondrial retrograde axonal transport play a role in the pathogenesis of mutant Hsp27-induced Charcot Marie Tooth Disease

(2017) Bernadett Kalmar et al.   HUMAN MOLECULAR GENETICS

Rab7 may be a novel therapeutic target for neurologic diseases as a key regulator in autophagy

(2017) Haixia Wen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Tubulin acetylation protects long-lived microtubules against mechanical ageing

(2017) Didier Portran et al.   NATURE CELL BIOLOGY

Defective axonal transport: A common pathological mechanism in inherited and acquired peripheral neuropathies

(2017) Robert Prior et al.   NEUROBIOLOGY OF DISEASE

Chaperone Proteins in the Central Nervous System and Peripheral Nervous System after Nerve Injury

(2017) Shalina S. Ousman et al.   Frontiers in Neuroscience

Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot–Marie–Tooth Disease

(2015) Sida Shen et al.   ACS Chemical Neuroscience

A novel perspective on neuron study: damaging and promoting effects in different neurons induced by mechanical stress

(2015) Yazhou Wang et al.   Biomechanics and Modeling in Mechanobiology

Building the Neuronal Microtubule Cytoskeleton

(2015) Lukas C. Kapitein et al.   NEURON

Regulation of Axonal Transport by Protein Kinases

(2015) Katherine L. Gibbs et al.   TRENDS IN BIOCHEMICAL SCIENCES

The axonal cytoskeleton: from organization to function

(2015) Josta T. Kevenaar et al.   Frontiers in Molecular Neuroscience

Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases

(2014) Juha M.T. Hyttinen et al.   AGEING RESEARCH REVIEWS

Surface chemistry modulates osteoblasts sensitivity to low fluid shear stress

(2014) Juan Xing et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function

(2013) J. Ross Buchan et al.   CELL

Reaction of small heat-shock proteins to different kinds of cellular stress in cultured rat hippocampal neurons

(2013) Britta Bartelt-Kirbach et al.   CELL STRESS & CHAPERONES

Autophagy and microtubules - new story, old players

(2013) R. Mackeh et al.   JOURNAL OF CELL SCIENCE

The axonal transport of mitochondria

(2012) W. M. Saxton et al.   JOURNAL OF CELL SCIENCE

SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition

(2012) Jiyeong Gal et al.   NEUROCHEMISTRY INTERNATIONAL

Charcot–Marie–Tooth disease and intracellular traffic

(2012) Cecilia Bucci et al.   PROGRESS IN NEUROBIOLOGY

Small Heat-Shock Protein HSPB1 Mutants Stabilize Microtubules in Charcot-Marie-Tooth Neuropathy

(2011) L. Almeida-Souza et al.   JOURNAL OF NEUROSCIENCE

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

(2011) Constantin d'Ydewalle et al.   NATURE MEDICINE

Parkin-mediated ubiquitin signalling in aggresome formation and autophagy

(2010) Lih-Shen Chin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Increased Monomerization of Mutant HSPB1 Leads to Protein Hyperactivity in Charcot-Marie-Tooth Neuropathy

(2010) Leonardo Almeida-Souza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retrograde axonal transport: pathways to cell death?

(2010) Eran Perlson et al.   TRENDS IN NEUROSCIENCES

Autophagy for the avoidance of neurodegeneration

(2009) F. Madeo et al.   GENES & DEVELOPMENT