Article
Cell Biology
Cara R. Schiavon, Gerald S. Shadel, Uri Manor
Summary: CMT disease is a progressive, inherited neurological disorder associated with mutations in at least 80 different genes. Clinical manifestations typically involve peripheral neurons, with some mutations potentially leading to mitochondrial mobility defects, suggesting a common underlying disease mechanism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marina Stavrou, Irene Sargiannidou, Elena Georgiou, Alexia Kagiava, Kleopas A. Kleopa
Summary: CMT disease is a genetically heterogeneous disorder affecting the peripheral nerves, with diverse molecular genetic mechanisms discovered over the past three decades. There are currently various treatment approaches in preclinical testing and clinical trials, including disease-specific targeted therapies and treatments targeting common pathways shared by different CMT types. As promising treatments advance to clinical translation, optimizing outcome measures, novel biomarkers, and appropriate trial designs are crucial to facilitate successful testing and validation of novel treatments for CMT patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Xuelian Zhang, Yaru Qiao, Ronglin Han, Yingjie Gao, Xun Yang, Ying Zhang, Ying Wan, Wei Yu, Xianchao Pan, Juan Xing
Summary: Charcot-Marie-Tooth (CMT) disease is a common inherited neurodegenerative disorder characterized by selective degeneration of peripheral nerves. This study focused on understanding the molecular mechanisms underlying the selective degeneration of peripheral neurons induced by CMT-causing mutations. The researchers found that daily repeated stress might be a key factor contributing to this degeneration. Specifically, a dominant missense mutation (S135F) in the HSPB1 protein was found to disrupt the transport of misfolded proteins and autophagosomes, leading to an accumulation of ubiquitinated protein aggregates and decreased cell adaptation to stress. These findings provide new insights into the pathogenesis of CMT neuropathy and suggest that targeting autophagy could be a promising therapeutic strategy.
Article
Clinical Neurology
Zoi Kontogeorgiou, Chrisoula Kartanou, Michail Rentzos, Panagiotis Kokotis, Evangelos Anagnostou, Thomas Zambelis, Elisabeth Chroni, Argyris Dinopoulos, Marios Panas, Georgios Koutsis, Georgia Karadima
Summary: By screening 60 patients with CMT2, dHMN, or HSN in the Greek population, 20 pathogenic or likely pathogenic variants were identified, highlighting the genetic and phenotypic variability of axonal CMT. The diagnostic yield of the customized gene panel in this study compares favorably with other European populations, contributing to the characterization of pathogenic variants related to axonal neuropathies.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2023)
Review
Clinical Neurology
Brett A. McCray, Steven S. Scherer
Summary: Inherited peripheral neuropathies are a group of genetically and phenotypically diverse disorders that result in degeneration of peripheral neurons, leading to sensory and motor dysfunction. Recent research has identified common pathological mechanisms among these diseases, including defects in axonal transport, mitochondrial dynamics, organelle-organelle contacts, and local axonal protein translation. These insights have informed emerging treatment strategies for inherited neuropathies, offering promising therapeutic opportunities.
Article
Clinical Neurology
Silvia Cipriani, Marta Guerrero-Valero, Stefano Tozza, Edward Zhao, Veith Vollmer, Danique Beijer, Matt Danzi, Cristina Rivellini, Dejan Lazarevic, Giovanni Battista Pipitone, Bianca Rose Grosz, Costanza Lamperti, Stefania Bianchi Marzoli, Paola Carrera, Marcella Devoto, Chiara Pisciotta, Davide Pareyson, Marina Kennerson, Stefano C. Previtali, Stephan Zuchner, Steven S. Scherer, Fiore Manganelli, Martin Bahler, Alessandra Bolino
Summary: The study identified that novel or very rare variants in the MYO9B gene are associated with CMT2 and isolated OA. Functional studies showed that variants in MYO9B impair protein expression level and motor activity, indicating its essential role in peripheral and central nervous system axons.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biology
Yingli Gu, Flora Guerra, Mingzheng Hu, Alexander Pope, Kijung Sung, Wanlin Yang, Simone Jetha, Thomas A. Shoff, Tessanya Gunatilake, Owen Dahlkamp, Linda Zhixia Shi, Fiore Manganelli, Maria Nolano, Yue Zhou, Jianqing Ding, Cecilia Bucci, Chengbiao Wu
Summary: The Rab7(V162M) mutation associated with Charcot Marie Tooth 2B peripheral neuropathy causes mitochondrial fragmentation in patient-derived fibroblasts and primary cultured sensory neurons. Inhibition of Drp1 or nucleotide binding to Rab7 can normalize the mitochondrial deficits.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neurosciences
Xihui Chen, Fangfang Liu, Kun Chen, Yufeng Wang, Anan Yin, Xiaowei Kang, Shanming Yang, Hanwen Zhao, Songqi Dong, Yunqing Li, Jing Chen, Yuanming Wu
Summary: The aim of this study was to determine the common pathogenic mechanism of TFG-related CMT2 caused by different mutations and establish a direct association between TFG haploinsufficiency and neurodegeneration. The results showed that TFG deficiency leads to neurite degeneration, resulting in the development of CMT2.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Cell Biology
Zeina Msheik, Stephanie Durand, Emilie Pinault, Martial Caillaud, Laetitia Vignaud, Fabrice Billet, Mohamed El Massry, Alexis Desmouliere
Summary: This study compared the sensorimotor and histological aspects of peripheral neuropathies in two rat models, sciatic nerve crush and Charcot-Marie-Tooth-1A (CMT1A) disease. Protein analysis revealed common pathological pathways between these two diseases and identified potential therapeutic targets.
NEURAL REGENERATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Ryan J. Mulligan, Bettina Winckler
Summary: Intracellular endosomal trafficking plays a crucial role in maintaining protein balance and cellular signaling pathways. Small GTPases, including Rab proteins, control the coordination of this trafficking. Rab7 is particularly important in regulating endosomal maturation and functions. Mutations in Rab7 cause Charcot-Marie-Tooth 2B disease, leading to peripheral neuropathy. This review focuses on the physiological interactions and control of Rab7 effectors in neurons, emphasizing the challenges of spatiotemporal regulation in neuronal processes. The impact of Rab7 mutations on effector interactions and balance in CMT2B models is also discussed.
Article
Neurosciences
Fan Chu, Jiaming Xu, Yong Wang, Yingjie Li, Yaling Wang, Zhijun Liu, Chuanzhou Li
Summary: X-linked Charcot-Marie-Tooth Disease type 1 (CMT1X) is a common form of inherited peripheral neuropathy caused by mutations in the GJB1 gene. This study investigated four CMT families in China and identified new and previously reported variants of GJB1. Cell biological analysis revealed that all mutants showed increased expression and aggregation compared to the wild-type. The study also found that mutated GJB1 induced intracellular stress granule formation and cytotoxicity.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Neurosciences
Ronja Markworth, Mathias Baehr, Katja Burk
Summary: Charcot-Marie-Tooth disease (CMT) is a group of clinically and genetically heterogeneous disorders that affect the peripheral nervous system, with disrupted intracellular transport identified as a common factor in the pathogenesis. Defects in intracellular transport in both neurons and Schwann cells can lead to the development of CMT.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Pooja Pravinbabu, Vikram V. Holla, Prashant Phulpagar, Nitish Kamble, Manjunath Netravathi, Ravi Yadav, Pramod Kumar Pal, Babylakshmi Muthusamy
Summary: This study describes the clinical and genetic features of a 17-year-old male with CMT4D, identifying a novel deletion mutation in the NDRG1 gene. The study expands the understanding of the clinical and genetic spectrum of CMT4D and suggests a novel splice isoform of NDRG1 as a potential cause for the neuropathy observed in this patient.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Rafael Sivera, Vincenzo Lupo, Marina Frasquet, Herminia Argente-Escrig, Jorge Alonso-Perez, Jordi Diaz-Manera, Luis Querol, Maria del Mar Garcia-Romero, Samuel Ignacio Pascual, Tania Garcia-Sobrino, Carmen Paradas, Juan Francisco Vazquez-Costa, Nuria Muelas, Elvira Millet, Juan Jesus Vilchez, Carmen Espinos, Teresa Sevilla
Summary: This study identified 15 patients with CMT2Z caused by MORC2 mutations in Spain, with most exhibiting a scapuloperoneal phenotype and a few showing a neurodevelopmental phenotype. The findings suggest a diverse spectrum of disease characteristics and clinical presentations.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Mariapaola Sidoli, Chelsey B. Reed, Cristina Scapin, Pablo Paez, Douglas R. Cavener, Randal J. Kaufman, Maurizio D'Antonio, M. Laura Feltri, Lawrence Wrabetz
Summary: Despite the interaction between Perk and calcineurin in P0S63del nerves, Perk deletion paradoxically improved S63del myelin defects. Additionally, genetic manipulation of calcineurin subunits showed context-dependent protective or toxic effects in S63del, suggesting high sensitivity of Schwann cells to alterations in calcineurin activity.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Yvonne E. Klingl, Donya Pakravan, Ludo Van den Bosch
Summary: ALS is a devastating neurodegenerative disease with limited treatment options. Research suggests that interference with histone deacetylases may be helpful in treating ALS.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Cell Biology
Donya Pakravan, Gabriele Orlando, Valerie Bercier, Ludo Van den Bosch
Summary: ALS is a late-onset neurodegenerative disease affecting motor neurons, with TDP-43 and FUS identified as LLPS proteins that form liquid droplets. Research is focused on understanding the underlying nature of this common pathology, with potential therapeutic strategies targeting LLPS for treating ALS.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Katarina Stoklund Dittlau, Emily N. Krasnow, Laura Fumagalli, Tijs Vandoorne, Pieter Baatsen, Axelle Kerstens, Giorgia Giacomazzi, Benjamin Pavie, Elisabeth Rossaert, Jimmy Beckers, Maurilio Sampaolesi, Philip Van Damme, Ludo Van den Bosch
Summary: This study established a versatile and reproducible in vitro model of a human motor unit to investigate the effects of ALS-causing mutations. It was observed that ALS-causing FUS mutations resulted in reduced neurite outgrowth, impaired neurite regrowth, and reduced NMJ numbers. Interestingly, the selective HDAC6 inhibitor Tubastatin A improved these outcomes, suggesting HDAC6 inhibition as a potential therapeutic strategy for ALS.
Review
Neurosciences
Elke Braems, Paraskevi Tziortzouda, Ludo Van Den Bosch
Summary: ALS is an incurable neurodegenerative disorder characterized by the loss of motor neurons. Alternative small animal models, such as nematodes, fruit flies, and zebrafish, have provided new insights into ALS pathomechanisms and therapeutic targets, complementing traditional rodent models in preclinical studies.
NEUROSCIENCE LETTERS
(2021)
Article
Multidisciplinary Sciences
Katarina Stoklund Dittlau, Emily N. Krasnow, Laura Fumagalli, Tijs Vandoorne, Pieter Baatsen, Axelle Kerstens, Giorgia Giacomazzi, Benjamin Pavie, Elisabeth Rossaert, Jimmy Beckers, Maurilio Sampaolesi, Philip Van Damme, Ludo Van Den Bosch
Summary: This study successfully created an in vitro model of a human motor unit with functional NMJs, identified and characterized the NMJs through immunocytochemistry and scanning electron microscopy, and confirmed the functionality of the NMJs.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Neurosciences
Robert Prior, Stijn Verschoren, Katlijn Vints, Tom Jaspers, Elisabeth Rossaert, Yvonne E. Klingl, Alessio Silva, Nicole Hersmus, Philip Van Damme, Ludo Van den Bosch
Summary: This study suggests that early treatment with HDAC3 inhibitors can increase myelination and improve electrophysiological recordings in CMT1A mice. However, high doses of HDAC3 inhibitors can lead to a decline in motor performance, reduced grip strength, and increased macrophage presence in peripheral nerves. Therefore, using the correct dosage of HDAC3 inhibitors is crucial when translating this approach to clinical settings for demyelinating forms of CMT or other neurological disorders.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Evelien Van Schoor, Mathieu Vandenbulcke, Valerie Bercier, Rik Vandenberghe, Julie van der Zee, Christine Van Broeckhoven, Markus Otto, Bernard Hanseeuw, Philip Van Damme, Ludo Van den Bosch, Dietmar Rudolf Thal
Summary: This study reports a novel frameshift mutation in the TUBA4A gene in a patient with semantic variant of primary progressive aphasia, suggesting a potential loss-of-function pathogenic mechanism associated with frontotemporal lobar degeneration (FTLD). The findings support the idea that N-terminal TUBA4A mutations are linked to FTLD-TDP.
Article
Biochemistry & Molecular Biology
Joni Vanneste, Thomas Vercruysse, Steven Boeynaems, Philip Van Damme, Dirk Daelemans, Ludo Van den Bosch
Summary: The study aimed to investigate the causal relationship between stress granule formation and nucleocytoplasmic transport deficits. The results demonstrate that while stress granules are formed in response to cellular stress, they are not a direct cause of stress-induced nucleocytoplasmic transport deficits.
Article
Clinical Neurology
Jonas Van Lent, Leen Vendredy, Elias Adriaenssens, Tatiana Da Silva Authier, Bob Asselbergh, Marcus Kaji, Sarah Weckhuysen, Ludo van den Bosch, Jonathan Baets, Vincent Timmerman
Summary: Charcot-Marie-Tooth disease (CMT) is the most common inherited disorder of the peripheral nervous system (PNS), with CMT1A accounting for 40-50% of cases. This study presents an organoid model derived from induced pluripotent stem cells that contains various cell types of the PNS, including myelinating human Schwann cells. They used this model to study disease signatures of CMT1A and found that downregulating PMP22 expression can ameliorate the myelin defects in CMT1A-organoids.
Article
Biochemistry & Molecular Biology
Martina Gatti, Katarina Stoklund Dittlau, Francesca Beretti, Laura Yedigaryan, Manuela Zavatti, Pietro Cortelli, Carla Palumbo, Emma Bertucci, Ludo van den Bosch, Maurilio Sampaolesi, Tullia Maraldi
Summary: Neuromuscular junctions are important for communication between spinal motor neurons and skeletal muscle, and their vulnerability in degenerative diseases like muscle atrophy is poorly understood. Recent studies have shown the regenerative potential of stem cells and extracellular vesicles in muscle fiber regeneration, but their role in counteracting NMJ perturbations is not clear. In this study, a co-culture system was used to investigate the effects of AFSC-derived EVs on NMJ alterations induced by muscle atrophy. The presence of EVs reduced morphological and functional defects and prevented oxidative stress in atrophic myotubes. This study provides a valuable tool for studying MN and myotube interactions and demonstrates the efficacy of AFSC-EVs in counteracting NMJ perturbations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Jimmy Beckers, Arun Kumar Tharkeshwar, Laura Fumagalli, Matilde Contardo, Evelien Van Schoor, Raheem Fazal, Dietmar Rudolf Thal, Siddharthan Chandran, Renzo Mancuso, Ludo Van Den Bosch, Philip Van Damme
Summary: In this study, iPSC-derived MNs from C9orf72-ALS patients and isogenic control lines were used to investigate the underlying mechanisms of autophagy-lysosome pathway dysregulation. The results showed that C9orf72 loss-of-function had minimal influence on autophagy-lysosome pathway phenotypes, but primarily caused impairment in endosome maturation. Moreover, increased phosphorylation of TBK1 at S172 was observed in MNs derived from C9orf72-ALS patients.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Cell Biology
Vincent E. Provasek, Manohar Kodavati, Wenting Guo, Haibo Wang, Istvan Boldogh, Ludo Van Den Bosch, Gavin Britz, Muralidhar L. Hegde
Summary: This study examined the impact of FUS gene mutations on the transcriptome of induced pluripotent stem cells and their differentiated motor neurons. The mutations were found to significantly alter the expression profiles of mRNAs and lncRNAs, and several key differentially regulated target pairs were identified. Functional enrichment analyses revealed potential pathways associated with neuronal development and carcinogenesis. The study also highlighted the associations between RNA metabolism, lncRNA regulation, and DNA damage repair. These findings provide insights into the molecular mechanisms underlying ALS-associated FUS mutations and potential therapeutic targets for ALS treatment.
Article
Cell Biology
Carola Torazza, Francesca Provenzano, Elena Gallia, Maria Cerminara, Matilde Balbi, Tiziana Bonifacino, Sara Tessitore, Silvia Ravera, Cesare Usai, Ilaria Musante, Aldamaria Puliti, Ludo Van Den Bosch, Paymaan Jafar-nejad, Frank Rigo, Marco Milanese, Giambattista Bonanno
Summary: This study demonstrates that downregulating mGluR5 expression can alleviate the reactive response and neurotoxicity of SOD1(G93A) astrocytes towards motor neurons, suggesting that mGluR5 may be a promising therapeutic target in ALS.
Editorial Material
Clinical Neurology
Rita Sattler, Bryan J. Traynor, Janice Robertson, Ludo Van den Bosch, Sami J. Barmada, Clive N. Svendsen, Matthew D. Disney, Tania F. Gendron, Philip C. Wong, Martin R. Turner, Adam Boxer, Suma Babu, Michael Benatar, Michael Kurnellas, Jonathan D. Rohrer, Christopher J. Donnelly, Lynette M. Bustos, Kendall Van Keuren-Jensen, Penny A. Dacks, Marwan N. Sabbagh
Summary: The summit highlighted the role of the C9ORF72 gene in FTD and ALS, covering disease mechanisms, therapeutic strategies, and biomarkers. Collaborative efforts aimed to break down existing disease silos and proposed composite endpoints for evaluating treatments covering clinical symptoms.
NEUROLOGY AND THERAPY
(2023)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.