期刊
JOURNAL OF NEUROSCIENCE RESEARCH
卷 95, 期 10, 页码 1993-2004出版社
WILEY
DOI: 10.1002/jnr.24034
关键词
Rab7; autophagy; autophagosome maturation; neurologic diseases
资金
- National Research Foundation for the Doctoral Program of Higher Education of China [20124423110002]
- Natural Science Foundation of Guangdong, China [2015A030313461]
- Project of Science and Technology Program of Guangzhou Bureau of Education, China [1201410359]
- PhD research Start-up Foundation of Guangzhou Medical University [2014C30]
Macroautophagy is an evolutionally conserved membrane trafficking pathway that delivers intracellular materials to lysosomes for degradation and recycling. Rab7, as a member of the Rab GTPase superfamily, has a unique role in the regulation of macroautophagy, especially in modulating autophagy flux. The functional states of Rab7 generally switch between GTP-bound and GDP-bound states under the control of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated GTP-Rab7 is capable of regulating autophagosome formation, autophagosome transportation along microtubules, endosonne and autophagosome maturation, as well as lysosonne biogenesis via interacting with its effector molecules. Rab7-mediated macroautophagy is closely associated with various pathological processes of several neurologic diseases, such as Parkinson's disease, Huntington's disease, Alzheimer's disease, Charcot-Marie-Tooth type 2B disease, and cerebral ischemic diseases. Considering that macroautophagy can be the prime therapeutic target in certain nervous system diseases, in-depth study of Rab7 in the regulation of macroautophagy may be helpful to identify novel strategies for the treatment of autophagy-related neurologic diseases. (C) 2017 Wiley Periodicals, Inc.
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