期刊
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
卷 15, 期 5, 页码 1019-1027出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s10237-015-0743-4
关键词
Compression; Tension; Neurons; Microenvironment
资金
- National Key Basic Research Project (Project 973) [2014CB541600]
- Fundamental Research Funds for the Central Universities [2015CDJZR]
- Chongqing University Postgraduates' Innovation Project [CYS14004]
A growing volume of experimental evidence demonstrates that mechanical stress plays a significant role in growth, proliferation, apoptosis, gene expression, electrophysiological properties and many other aspects of neurons. In this review, first, the mechanical microenvironment and properties of neurons under in vivo conditions are introduced and analyzed. Second, research works in recent decades on the effects of different mechanical forces, especially compression and tension, on various neurons, including dorsal root ganglion neurons, retinal ganglion cells, cerebral cortex neurons, hippocampus neurons, neural stem cells, and other neurons, are summarized. Previous research results demonstrate that mechanical stress can not only injure neurons by damaging their morphology, impacting their electrophysiological characteristics and gene expression, but also promote neuron self-repair. Finally, some future perspectives in neuron research are discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据