Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages

Phagocytic Integrins: Activation and Signaling

(2020) Alvaro Torres-Gomez et al.   Frontiers in Immunology

Candida and Complement: New Aspects in an Old Battle

(2020) Verena Harpf et al.   Frontiers in Immunology

Biodiverse Histoplasma Species Elicit Distinct Patterns of Pulmonary Inflammation following Sublethal Infection

(2020) Grant S. Jones et al.   mSphere

The C3a/C3aR axis mediates anti-inflammatory activity and protects against uropathogenic E coli-induced kidney injury in mice

(2019) Kun-Yi Wu et al.   KIDNEY INTERNATIONAL

Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen

(2019) Edwin E. Jeng et al.   Cell Host & Microbe

Fungal dissemination is limited by liver macrophage filtration of the blood

(2019) Donglei Sun et al.   Nature Communications

Intracortical Administration of the Complement C3 Receptor Antagonist Trifluoroacetate Modulates Microglia Reaction after Brain Injury

(2019) Roxana Surugiu et al.   NEURAL PLASTICITY

Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement

(2018) Spencer A. Freeman et al.   CELL

Flying under the radar: Histoplasma capsulatum avoidance of innate immune recognition

(2018) Stephanie C. Ray et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A G-protein-coupled chemoattractant receptor recognizes lipopolysaccharide for bacterial phagocytosis

(2018) Miao Pan et al.   PLOS BIOLOGY

The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

(2018) Matthew J Shurtleff et al.   eLife

Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens

(2018) Michael S. Haney et al.   NATURE GENETICS

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

(2018) Alexandra Litvinchuk et al.   NEURON

The p90 ribosomal S6 kinase–UBR5 pathway controls Toll-like receptor signaling via miRNA-induced translational inhibition of tumor necrosis factor receptor–associated factor 3

(2017) Jin Hwa Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monitoring C3aR Expression Using a Floxed tdTomato-C3aR Reporter Knock-in Mouse

(2017) Katharina M. Quell et al.   JOURNAL OF IMMUNOLOGY

Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens

(2017) David W. Morgens et al.   Nature Communications

The transcription factor CHOP, an effector of the integrated stress response, is required for host sensitivity to the fungal intracellular pathogen Histoplasma capsulatum

(2017) Bevin C. English et al.   PLoS Pathogens

Analytical Prediction of the Spatiotemporal Distribution of Chemoattractants around Their Source: Theory and Application to Complement-Mediated Chemotaxis

(2017) Volkmar Heinrich et al.   Frontiers in Immunology

Primary macrophages and J774 cells respond differently to infection with Mycobacterium tuberculosis

(2017) Nuria Andreu et al.   Scientific Reports

Complement pathway amplifies caspase-11–dependent cell death and endotoxin-induced sepsis severity

(2016) Brooke A. Napier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Revisiting old friends: Developments in understanding Histoplasma capsulatum pathogenesis

(2016) Jon P. Woods   JOURNAL OF MICROBIOLOGY

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

A complement–microglial axis drives synapse loss during virus-induced memory impairment

(2016) Michael J. Vasek et al.   NATURE

Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes

(2016) David W Morgens et al.   NATURE BIOTECHNOLOGY

Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

(2016) Richard M Deans et al.   Nature Chemical Biology

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors

(2016) Ryan J Park et al.   NATURE GENETICS

Interactions of fungal pathogens with phagocytes

(2016) Lars P. Erwig et al.   NATURE REVIEWS MICROBIOLOGY

The Eng1 β-Glucanase Enhances Histoplasma Virulence by Reducing β-Glucan Exposure

(2016) Andrew L. Garfoot et al.   mBio

The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia

(2016) Kimberle Shen et al.   Cell Reports

CD103+ Conventional Dendritic Cells Are Critical for TLR7/9-Dependent Host Defense against Histoplasma capsulatum, an Endemic Fungal Pathogen of Humans

(2016) Nancy Van Prooyen et al.   PLoS Pathogens

Gnb isoforms control a signaling pathway comprising Rac1, Plc 2, and Plc 3 leading to LFA-1 activation and neutrophil arrest in vivo

(2015) H. Block et al.   BLOOD

Histoplasma capsulatumsurmounts obstacles to intracellular pathogenesis

(2015) Andrew L. Garfoot et al.   FEBS Journal

Histoplasma capsulatum, lung infection and immunity

(2015) Michael C Horwath et al.   Future Microbiology

Real-Time Imaging of Interactions of Neutrophils with Cryptococcus neoformans Demonstrates a Crucial Role of Complement C5a-C5aR Signaling

(2015) Donglei Sun et al.   INFECTION AND IMMUNITY

Is the Complement Activation Product C3a a Proinflammatory Molecule? Re-evaluating the Evidence and the Myth

(2015) Liam G. Coulthard et al.   JOURNAL OF IMMUNOLOGY

Macrophage cell death and transcriptional response are actively triggered by the fungal virulence factor Cbp1 duringH.capsulatuminfection

(2015) Dervla T. Isaac et al.   MOLECULAR MICROBIOLOGY

Signaling Networks that Regulate Cell Migration

(2015) Peter Devreotes et al.   Cold Spring Harbor Perspectives in Biology

CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway

(2015) Juin-Hua Huang et al.   PLoS Pathogens

GPCR signaling along the endocytic pathway

(2014) Roshanak Irannejad et al.   CURRENT OPINION IN CELL BIOLOGY

Generation of membrane structures during phagocytosis and chemotaxis of macrophages: role and regulation of the actin cytoskeleton

(2014) Pablo Rougerie et al.   IMMUNOLOGICAL REVIEWS

Phagocytosis: receptors, signal integration, and the cytoskeleton

(2014) Spencer A. Freeman et al.   IMMUNOLOGICAL REVIEWS

Canonical and Noncanonical G-Protein Signaling Helps Coordinate Actin Dynamics To Promote Macrophage Phagocytosis of Zymosan

(2014) N.-N. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps

(2014) Martin Kampmann et al.   Nature Protocols

Easy quantitative assessment of genome editing by sequence trace decomposition

(2014) Eva K. Brinkman et al.   NUCLEIC ACIDS RESEARCH

TANGO: a generic tool for high-throughput 3D image analysis for studying nuclear organization

(2013) Jean Ollion et al.   BIOINFORMATICS

A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility

(2013) Michael C. Bassik et al.   CELL

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Overview of Complement Activation and Regulation

(2013) Marina Noris et al.   SEMINARS IN NEPHROLOGY

The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties

(2012) Suet‑Mien Tan   BIOSCIENCE REPORTS

TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

(2012) Thorkell Gudjonsson et al.   CELL

Complement plays a central role in Candida albicans-induced cytokine production by human PBMCs

(2012) Shih-Chin Cheng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The 3-Hydroxy-Methylglutaryl Coenzyme A LyaseHCL1Is Required for Macrophage Colonization by Human Fungal Pathogen Histoplasma capsulatum

(2012) Dervla T. Isaac et al.   INFECTION AND IMMUNITY

Expression of Complement Components and Regulators by Different Subtypes of Bone Marrow-Derived Macrophages

(2012) Chang Luo et al.   INFLAMMATION

The Cell Biology of Phagocytosis

(2011) Ronald S. Flannagan et al.   Annual Review of Pathology-Mechanisms of Disease

Blurred line between chemotactic chase and phagocytic consumption: an immunophysical single-cell perspective

(2011) V. Heinrich et al.   JOURNAL OF CELL SCIENCE

Target-specific mechanics of phagocytosis: protrusive neutrophil response to zymosan differs from the uptake of antibody-tagged pathogens

(2011) C.-Y. Lee et al.   JOURNAL OF CELL SCIENCE

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

(2011) Helen S. Goodridge et al.   NATURE

Epidemiology of Invasive Mycoses in North America

(2010) Michael A. Pfaller et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Dynamic macrophage “probing” is required for the efficient capture of phagocytic targets

(2010) Ronald S. Flannagan et al.   JOURNAL OF CELL BIOLOGY

Distinct roles of complement receptor 3, Dectin-1, and sialic acids in murine macrophage interaction with Histoplasma yeast

(2010) Jr-Shiuan Lin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

(2009) Eran Eden et al.   BMC BIOINFORMATICS

Complement C3 Plays an Essential Role in the Control of Opportunistic Fungal Infections

(2009) S. V. Tsoni et al.   INFECTION AND IMMUNITY

The role of the anaphylatoxins in health and disease

(2009) Andreas Klos et al.   MOLECULAR IMMUNOLOGY

Role of Complement in Protection against Cryptococcus gattii Infection

(2008) K. L. Mershon et al.   INFECTION AND IMMUNITY

Histoplasma capsulatum manifests preferential invasion of phagocytic subpopulations in murine lungs

(2008) George S. Deepe et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Kindlin-3 is essential for integrin activation and platelet aggregation

(2008) Markus Moser et al.   NATURE MEDICINE

Lifeact: a versatile marker to visualize F-actin

(2008) Julia Riedl et al.   NATURE METHODS

Complement evasion by human pathogens

(2008) John D. Lambris et al.   NATURE REVIEWS MICROBIOLOGY

Histoplasma Requires SID1, a Member of an Iron-Regulated Siderophore Gene Cluster, for Host Colonization

(2008) Lena H. Hwang et al.   PLoS Pathogens