Article
Microbiology
Macario Osorio-Concepcion, Carlos Lax, Eusebio Navarro, Francisco E. Nicolas, Victoriano Garre
Summary: Epigenetic modifications control the pathogenicity of human pathogenic fungi, with high levels of 6mA found in the genome of Mucorales. Mutagenesis experiments revealed that the dmt1 gene plays a crucial role in dimorphic transition and spore-macrophage interaction in Mucor lusitanicus.
Article
Microbiology
Jin-Li Ding, Kang Wei, Ming-Guang Feng, Sheng-Hua Ying
Summary: The Atg4 gene plays a crucial role in the autophagy process of the insect fungal pathogen Beauveria bassiana. Its loss affects fungal biomass accumulation, stress tolerance, conidia production, and virulence.
Article
Immunology
Trung Anh Trieu, Phuong Anh Nguyen, Mai Ngoc Le, Huy Nhat Chu
Summary: This study investigated the roles of myosin II proteins in Mucor circinelloides and found that these proteins play a critical role in polarity growth, sporulation, morphology, and pathogenesis of the fungus. The findings suggest that targeting the myosin family could be a potential therapeutic strategy for treating mucormycosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Evan Mitchell, Andrea L. Graham, Francisco Ubeda, Geoff Wild
Summary: Women generally exhibit stronger immune responses and pathogens tend to be more virulent in men, which current explanations cannot account for. This study proposes an alternative explanation based on the transmission of pathogens from mother to child, using a mathematical model of the co-evolution of host immunocompetence and pathogen virulence.
NATURE COMMUNICATIONS
(2022)
Article
Plant Sciences
Eytham Souibgui, Christophe Bruel, Mathias Choquer, Amelie de Vallee, Cindy Dieryckx, Jean William Dupuy, Marie-Pascale Latorse, Christine Rascle, Nathalie Poussereau
Summary: Fungi, the most prevalent plant pathogens, secrete effectors to infect hosts. The study demonstrates the essential role of clathrin heavy chain in the pathogenicity of Botrytis cinerea and its impact on protein secretion.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Immunology
Alessandro F. Valdez, Daniel Zamith Miranda, Allan Jefferson Guimaraes, Leonardo Nimrichter, Joshua D. Nosanchuk
Summary: This review discusses the virulence factors and pathogenesis traits of Histoplasma capsulatum, a thermally dimorphic fungus causing histoplasmosis. Understanding these mechanisms is crucial for developing new preventive and therapeutic interventions.
Article
Microbiology
Marina Valente Navarro, Yasmin Nascimento de Barros, Wilson Dias Segura, Alison Felipe Alencar Chaves, Grasielle Pereira Jannuzzi, Karen Spadari Ferreira, Patricia Xander, Wagner Luiz Batista
Summary: The study revealed the crucial role of PbDrk1 in cell wall modulation of P. brasiliensis, affecting fungal resistance to different cell wall-disturbing agents and influencing cell wall morphogenesis by regulating various genes associated with cell wall modulation. It also showed an increased phagocytic index and proinflammatory cytokine levels in response to PbDrk1, suggesting its significance as a potential target for antifungal molecular activity.
Article
Multidisciplinary Sciences
Laila Gasmi, Sehyeon Baek, Jong Cheol Kim, Sihyeon Kim, Mi Rong Lee, So Eun Park, Tae Young Shin, Se Jin Lee, Bruce L. Parker, Jae Su Kim
Summary: The study characterized the genetic diversity of genes involved in various mechanisms of the infective cycle in 42 isolates of Beauveria bassiana, revealing the significant impact of genetic diversity on the biological features of the fungus. Correlation analyses showed that different genes contribute to the virulence, thermotolerance, and growth rate of B. bassiana isolates.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Ru Li, Fengyue Chen, Shuangcai Li, Luying Yuan, Lijiu Zhao, Shigen Tian, Baoshan Chen
Summary: C. parasitica and hypoviruses are used as a model system to study fungal pathogenesis and virus-host interactions. Lysine acetylation is found to play a regulatory role in cell processes and signaling. Comparative acetylome analysis reveals differential acetylation in 80 proteins between C. parasitica strains with and without CHV1 infection, with these proteins being involved in various biological processes and enriched in metabolic processes.
MOLECULAR PLANT PATHOLOGY
(2023)
Article
Microbiology
Chaohui Li, Weibo Sun, Shulin Cao, Rongxian Hou, Xiaogang Li, Liang Ming, Jialiang Kan, Yancun Zhao, Fengquan Liu
Summary: In this study, the function of the CfMK1 gene in C. fructicola was characterized, revealing its critical roles in aerial hyphal growth, reproduction, autolysis, appressorium formation, and pathogenicity.
Article
Multidisciplinary Sciences
Yasuhiko Matsumoto, Yu Sugiyama, Tae Nagamachi, Asami Yoshikawa, Takashi Sugita
Summary: The study found that the hog1 gene plays a critical role in regulating cellular stress responses in T. asahii. The mutant is sensitive to high temperature, cell membrane stress, oxidative stress, and antifungal drugs. It also exhibits sensitivity to different stresses under glucose-rich and glucose-restricted conditions, and has attenuated virulence against silkworms.
SCIENTIFIC REPORTS
(2023)
Article
Agriculture, Multidisciplinary
Rongxian Hou, Kaihuai Li, Baodian Guo, Yangyang Zhao, Chaohui Li, Bao Tang, Weibo Sun, Bo Wang, Wenchan Chen, Cong Sheng, Jialiang Kan, Yancun Zhao, Fengquan Liu
Summary: This study identified the potential target of heat-stable antifungal factor (HSAF) in fungi and found that HSAF binds to specific sites on VpVeb1, resulting in decreased virulence of V. pyri.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
A. Rehman Khalid, Shumin Zhang, Xiumei Luo, Hamayun Shaheen, Afshan Majeed, Mehdi Maqbool, Noosheen Zahid, Junaid Rahim, Maozhi Ren, Dan Qiu
Summary: The deletion mutant of the FoATG12 gene in the potato dry rot fungus Fusarium oxysporum exhibited reduced virulence and impaired aerial hyphae formation. This highlights the significant role of the FoATG12 gene in the pathogenicity and production of aerial hyphae in F. oxysporum, providing insights for pathogen control research and potential impacts on potato crops.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Jin-Li Ding, Kang Wei, Ming-Guang Feng, Sheng-Hua Ying
Summary: In this study, researchers identified and functionally characterized five enterotoxin_A domain proteins in filamentous fungus B. bassiana. These proteins play important roles in stress response, development, and virulence. The loss of these proteins leads to reduced conidial production and increased sensitivity to oxidative and cell wall-perturbing stresses. Additionally, the loss of these proteins causes changes in the carbohydrate profiles of the fungal cell surface, which enhance host immune reactions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Hongjia Han, Fangjiao Lv, Zhishan Liu, Tongge Chen, Tianzi Xue, Wenxing Liang, Mengjie Liu
Summary: The role of Taf14 in filamentous phytopathogenic fungi was investigated in this study, and the BcTaf14 deletion strain showed pleiotropic defects including slow growth, reduced virulence, and altered stress responses. BcTaf14 interacted with a crotonylated peptide and the mutation of key sites disrupted this interaction. The absence of the ET domain at the C-terminus affected the localization and function of BcTaf14.
MOLECULAR PLANT PATHOLOGY
(2023)
