A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors

Persistent HIV-1 replication maintains the tissue reservoir during therapy

(2016) Ramon Lorenzo-Redondo et al.   NATURE

A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin

(2016) Gregory A. Sowd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

(2015) Traver Hart et al.   CELL

LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes

(2015) Parmit Kumar Singh et al.   GENES & DEVELOPMENT

The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface

(2015) Kara L. McKinley et al.   MOLECULAR CELL

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

(2015) Matthew R. Gardner et al.   NATURE

Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy–treated macaques

(2015) Philip J Santangelo et al.   NATURE METHODS

Influence of Glycosylation Inhibition on the Binding of KIR3DL1 to HLA-B*57:01

(2015) Wilhelm Salzberger et al.   PLoS One

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins

(2015) Kathrin Schumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion

(2015) E. S. Egan et al.   SCIENCE

Identification and characterization of essential genes in the human genome

(2015) T. Wang et al.   SCIENCE

HIV cell-to-cell transmission: effects on pathogenesis and antiretroviral therapy

(2015) Luis M. Agosto et al.   TRENDS IN MICROBIOLOGY

Dynamic coupling of ALCAM to the actin cortex strengthens cell adhesion to CD6

(2014) J. te Riet et al.   JOURNAL OF CELL SCIENCE

JAM-A and ALCAM are therapeutic targets to inhibit diapedesis across the BBB of CD14+ CD16+ monocytes in HIV-infected individuals

(2014) Dionna W. Williams et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

(2014) Pablo Tebas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Legionella pneumophila type IV effectors hijack the transcription and translation machinery of the host cell

(2014) Monica Rolando et al.   TRENDS IN CELL BIOLOGY

Comprehensive Identification of Host Modulators of HIV-1 Replication using Multiple Orthologous RNAi Reagents

(2014) Jian Zhu et al.   Cell Reports

ICAM-1-Dependent Homotypic Aggregates Regulate CD8 T Cell Effector Function and Differentiation during T Cell Activation

(2013) N. A. Zumwalde et al.   JOURNAL OF IMMUNOLOGY

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

Human Immunodeficiency Virus and Heparan Sulfate: From Attachment to Entry Inhibition

(2013) Bridgette J. Connell et al.   Frontiers in Immunology

Novel role for ALCAM in lymphatic network formation and function

(2012) Maria Iolyeva et al.   FASEB JOURNAL

ATARiS: Computational quantification of gene suppression phenotypes from multisample RNAi screens

(2012) D. D. Shao et al.   GENOME RESEARCH

Attachment of Chlamydia trachomatis L2 to host cells requires sulfation

(2012) D. M. Rosmarin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use and Abuse of RNAi to Study Mammalian Gene Function

(2012) W. G. Kaelin   SCIENCE

Generation of Transmitted/Founder HIV-1 Infectious Molecular Clones and Characterization of Their Replication Capacity in CD4 T Lymphocytes and Monocyte-Derived Macrophages

(2011) C. Ochsenbauer et al.   JOURNAL OF VIROLOGY

Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy

(2011) Alex Sigal et al.   NATURE

Host factors mediating HIV-1 replication

(2011) Brian M. Friedrich et al.   VIRUS RESEARCH

Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue

(2010) Gilad Doitsh et al.   CELL

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Rapid creation and quantitative monitoring of high coverage shRNA libraries

(2009) Michael C Bassik et al.   NATURE METHODS

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Programmed assembly of 3-dimensional microtissues with defined cellular connectivity

(2009) Z. J. Gartner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential Tyrosine Sulfation of CXCR4 by Tyrosylprotein Sulfotransferases†

(2008) Christoph Seibert et al.   BIOCHEMISTRY

Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication

(2008) Renate König et al.   CELL

Genome-Scale RNAi Screen for Host Factors Required for HIV Replication

(2008) Honglin Zhou et al.   Cell Host & Microbe

A Synaptic Basis for Paracrine Interleukin-2 Signaling during Homotypic T Cell Interaction

(2008) Catherine A. Sabatos et al.   IMMUNITY

A Multicolor Panel of Novel Lentiviral “Gene Ontology” (LeGO) Vectors for Functional Gene Analysis

(2008) Kristoffer Weber et al.   MOLECULAR THERAPY

Maraviroc for Previously Treated Patients with R5 HIV-1 Infection

(2008) Roy M. Gulick et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

(2008) B. F. Keele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CCR5 Δ32 Polymorphism: Associated with Gallbladder Cancer Susceptibility

(2008) A. Srivastava et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

(2008) Abraham L. Brass et al.   SCIENCE

Regulation of Zebrafish Skeletogenesis by ext2/dackel and papst1/pinscher

(2008) Aurélie Clément et al.   PLoS Genetics