期刊
MAGNETIC RESONANCE IN MEDICINE
卷 69, 期 6, 页码 1657-1664出版社
WILEY
DOI: 10.1002/mrm.24398
关键词
high-resolution; functional MRI; echo-planar imaging; three-dimensional; two-dimensional; physiological noise
资金
- MRC [G0901275]
- Wellcome Trust [079866/Z/06/Z]
- MRC [G0901275] Funding Source: UKRI
- Wellcome Trust [079866/Z/06/Z] Funding Source: Wellcome Trust
- Medical Research Council [G0901275] Funding Source: researchfish
High-resolution functional MRI (fMRI) offers unique possibilities for studying human functional neuroanatomy. Although high-resolution fMRI has proven its potential at 7 T, most fMRI studies are still performed at rather low spatial resolution at 3 T. We optimized and compared single-shot two-dimensional echo-planar imaging (EPI) and multishot three-dimensional EPI high-resolution fMRI protocols. We extended image-based physiological noise correction from two-dimensional EPI to multishot three-dimensional EPI. The functional sensitivity of both acquisition schemes was assessed in a visual fMRI experiment. The physiological noise correction increased the sensitivity significantly, can be easily applied, and requires simple recordings of pulse and respiration only. The combination of three-dimensional EPI with physiological noise correction provides exceptional sensitivity for 1.5 mm high-resolution fMRI at 3 T, increasing the temporal signal-to-noise ratio by more than 25% compared to two-dimensional EPI. Magn Reson Med, 2013. (c) 2012 Wiley Periodicals, Inc.
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