Quantitative super-resolution imaging of pathological aggregates reveals distinct toxicity profiles in different synucleinopathies
出版年份 2022 全文链接
标题
Quantitative super-resolution imaging of pathological aggregates reveals distinct toxicity profiles in different synucleinopathies
作者
关键词
-
出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 119, Issue 41, Pages -
出版商
Proceedings of the National Academy of Sciences
发表日期
2022-10-08
DOI
10.1073/pnas.2205591119
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- A Potential Mechanism for Targeting Aggregates With Proteasomes and Disaggregases in Liquid Droplets
- (2022) Emma Mee Hayes et al. Frontiers in Aging Neuroscience
- Uncovering the universality of self-replication in protein aggregation and its link to disease
- (2022) Georg Meisl et al. Science Advances
- Imaging protein aggregates in the serum and cerebrospinal fluid in Parkinson’s disease
- (2021) Evgeniia Lobanova et al. BRAIN
- Microglia contribute to the propagation of Aβ into unaffected brain tissue
- (2021) Paolo d’Errico et al. NATURE NEUROSCIENCE
- Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates
- (2021) Jack H. Brelstaff et al. Science Advances
- Stress- and ubiquitylation-dependent phase separation of the proteasome
- (2020) Sayaka Yasuda et al. NATURE
- The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
- (2020) Anne-Laure Mahul-Mellier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson’s disease familial A53T mutation
- (2020) Yunpeng Sun et al. CELL RESEARCH
- The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation
- (2020) Georg Meisl et al. CURRENT OPINION IN NEUROBIOLOGY
- Structures of α-synuclein filaments from multiple system atrophy
- (2020) Manuel Schweighauser et al. NATURE
- High-Throughput Image-Based Aggresome Quantification
- (2020) Laetitia Lesire et al. SLAS Discovery
- Quantum yield and brightness
- (2020) Ka-Leung Wong et al. JOURNAL OF LUMINESCENCE
- Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease
- (2020) Hendrik Wesseling et al. CELL
- Ultrafast data mining of molecular assemblies in multiplexed high-density super-resolution images
- (2019) Yandong Yin et al. Nature Communications
- Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation
- (2019) Dana Laor et al. Nature Communications
- Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme
- (2019) Rachel Cliffe et al. Cell Reports
- Transmission of α-synuclein seeds in neurodegenerative disease: recent developments
- (2019) Richard J. Karpowicz et al. LABORATORY INVESTIGATION
- Atomic force microscopy for single molecule characterisation of protein aggregation
- (2019) Francesco Simone Ruggeri et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- The nucleolus functions as a phase-separated protein quality control compartment
- (2019) F. Frottin et al. SCIENCE
- Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
- (2019) Suman De et al. Nature Communications
- N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of their Oligomers by the Proteasome Holoenzyme
- (2019) Yu Ye et al. JOURNAL OF MOLECULAR BIOLOGY
- α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities
- (2019) Parvez Alam et al. JOURNAL OF NEUROCHEMISTRY
- Structural mapping of oligomeric intermediates in an amyloid assembly pathway
- (2019) Theodoros K Karamanos et al. eLife
- In vivo detection of tau fibrils and amyloid β aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy
- (2019) Maria Calvo-Rodriguez et al. Acta Neuropathologica Communications
- Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity
- (2018) Franziska Kundel et al. ACS Chemical Biology
- Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’s disease brain
- (2018) Wei Hong et al. ACTA NEUROPATHOLOGICA
- Optical Structural Analysis of Individual α-Synuclein Oligomers
- (2018) Juan A. Varela et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment
- (2018) Qiang Guo et al. CELL
- Super-Resolution Imaging of Amyloid Structures over Extended Times Using Transient Binding of Single Thioflavin T Molecules
- (2018) Kevin Spehar et al. CHEMBIOCHEM
- Tau protein liquid–liquid phase separation can initiate tau aggregation
- (2018) Susanne Wegmann et al. EMBO JOURNAL
- Shedding light on aberrant interactions - a review of modern tools for studying protein aggregates
- (2018) Franziska Kundel et al. FEBS Journal
- Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases
- (2018) Minee L. Choi et al. FEBS Journal
- Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes
- (2018) Johnny Habchi et al. Nature Chemistry
- Cryo-EM structure of alpha-synuclein fibrils
- (2018) Ricardo Guerrero-Ferreira et al. eLife
- Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells
- (2018) Daniel R. Whiten et al. CHEMBIOCHEM
- Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases
- (2018) Claudio Soto et al. NATURE NEUROSCIENCE
- A new era for understanding amyloid structures and disease
- (2018) Matthew G. Iadanza et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Quantifying Co-Oligomer Formation by α-Synuclein
- (2018) Marija Iljina et al. ACS Nano
- Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale
- (2018) Ji-Eun Lee et al. NANO LETTERS
- Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
- (2017) Giuliana Fusco et al. SCIENCE
- Inhibiting the Ca 2+ Influx Induced by Human CSF
- (2017) Anna Drews et al. Cell Reports
- Thioflavin T as an amyloid dye: fibril quantification, optimal concentration and effect on aggregation
- (2017) Christine Xue et al. Royal Society Open Science
- Polarized super-resolution structural imaging inside amyloid fibrils using Thioflavine T
- (2017) Haitham A. Shaban et al. Scientific Reports
- Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-β
- (2017) Dag Sehlin et al. Scientific Reports
- Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration
- (2016) Michel Goedert et al. BRAIN
- AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species
- (2016) Francesco Simone Ruggeri et al. CURRENT PHARMACEUTICAL DESIGN
- Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases
- (2016) Ashley N. Nilson et al. JOURNAL OF ALZHEIMERS DISEASE
- Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate
- (2016) Ting Yang et al. JOURNAL OF NEUROSCIENCE
- Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons
- (2016) Dorothea Pinotsi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein
- (2016) Marija Iljina et al. Scientific Reports
- Fast Flow Microfluidics and Single-Molecule Fluorescence for the Rapid Characterization of α-Synuclein Oligomers
- (2015) Mathew H. Horrocks et al. ANALYTICAL CHEMISTRY
- Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease
- (2015) A. Gustot et al. BIOCHEMICAL JOURNAL
- Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells
- (2015) M. Usenovic et al. JOURNAL OF NEUROSCIENCE
- Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
- (2015) Serene W. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A mechanistic model of tau amyloid aggregation based on direct observation of oligomers
- (2015) Sarah L. Shammas et al. Nature Communications
- An optimized lactate dehydrogenase release assay for screening of drug candidates in neuroscience
- (2015) Simon Kaja et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- ThunderSTORM: a comprehensive ImageJ plug-in for PALM and STORM data analysis and super-resolution imaging
- (2014) Martin Ovesný et al. BIOINFORMATICS
- Single App knock-in mouse models of Alzheimer's disease
- (2014) Takashi Saito et al. NATURE NEUROSCIENCE
- Superresolution Imaging of Amyloid Fibrils with Binding-Activated Probes
- (2013) Jonas Ries et al. ACS Chemical Neuroscience
- Polymorph-Specific Kinetics and Thermodynamics of β-Amyloid Fibril Growth
- (2013) Wei Qiang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Proteasomes Activate Aggresome Disassembly and Clearance by Producing Unanchored Ubiquitin Chains
- (2013) Rui Hao et al. MOLECULAR CELL
- Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
- (2013) Changyoun Kim et al. Nature Communications
- α-Synuclein oligomers and clinical implications for Parkinson disease
- (2012) Lorraine V. Kalia et al. ANNALS OF NEUROLOGY
- Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
- (2012) Nunilo Cremades et al. CELL
- Detection of α-Synuclein Amyloidogenic Aggregates in Vitro and in Cells using Light-Switching Dipyridophenazine Ruthenium(II) Complexes
- (2012) Nathan P. Cook et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Evaluation of fluorophores for optimal performance in localization-based super-resolution imaging
- (2011) Graham T Dempsey et al. NATURE METHODS
- Molecular mechanism of Thioflavin-T binding to amyloid fibrils
- (2010) Matthew Biancalana et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies
- (2010) Dee Shen et al. CELL BIOCHEMISTRY AND BIOPHYSICS
- Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies
- (2010) He-Jin Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Highly inclined thin illumination enables clear single-molecule imaging in cells
- (2008) Makio Tokunaga et al. NATURE METHODS
- Whole-cell 3D STORM reveals interactions between cellular structures with nanometer-scale resolution
- (2008) Bo Huang et al. NATURE METHODS
- Three-Dimensional Super-Resolution Imaging by Stochastic Optical Reconstruction Microscopy
- (2008) B. Huang et al. SCIENCE
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