Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates
出版年份 2021 全文链接
标题
Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates
作者
关键词
-
出版物
Science Advances
Volume 7, Issue 43, Pages -
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2021-10-22
DOI
10.1126/sciadv.abg4980
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Dystrophic microglia in late‐onset Alzheimer's disease
- (2020) Wolfgang J. Streit et al. GLIA
- Extracellular microparticles exacerbate oxidative damage to retinal pigment epithelial cells
- (2020) Chun Yang et al. EXPERIMENTAL CELL RESEARCH
- Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
- (2020) Jacob W. Vogel et al. Nature Communications
- Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia
- (2020) Nicole Scott‐Hewitt et al. EMBO JOURNAL
- Cryo-EM structures of tau filaments
- (2020) Sjors HW Scheres et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer’s Disease Genetics
- (2020) Anna Podleśny-Drabiniok et al. TRENDS IN NEUROSCIENCES
- Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor
- (2019) Kevin Carvalho et al. BRAIN
- Extracellular tau induces microglial phagocytosis of living neurons in cell cultures
- (2019) Katryna Pampuscenko et al. JOURNAL OF NEUROCHEMISTRY
- Spreading of Tau Pathology in Sporadic Alzheimer’s Disease Along Cortico-cortical Top-Down Connections
- (2018) Heiko Braak et al. CEREBRAL CORTEX
- The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease
- (2018) Sarah C. Hopp et al. Journal of Neuroinflammation
- Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
- (2018) Tyler J. Bussian et al. NATURE
- Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia
- (2018) Jack Brelstaff et al. Cell Reports
- Microglia mediate non-cell-autonomous cell death of retinal ganglion cells
- (2018) Akiko Takeda et al. GLIA
- STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
- (2018) Damian Szklarczyk et al. NUCLEIC ACIDS RESEARCH
- Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease
- (2017) Anna Vilalta et al. FEBS Journal
- Mechanisms of NMDA Receptor- and Voltage-Gated L-Type Calcium Channel-Dependent Hippocampal LTP Critically Rely on Proteolysis That Is Mediated by Distinct Metalloproteinases
- (2017) Grzegorz Wiera et al. JOURNAL OF NEUROSCIENCE
- Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation
- (2017) William A. McEwan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Adipocyte-secreted chemerin is processed to a variety of isoforms and influences MMP3 and chemokine secretion through an NFkB-dependent mechanism
- (2016) Helen J. Dranse et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
- (2016) Maxim V. Kuleshov et al. NUCLEIC ACIDS RESEARCH
- Complement and microglia mediate early synapse loss in Alzheimer mouse models
- (2016) S. Hong et al. SCIENCE
- TNF-α stimulates MMP-3 production via PGE2 signalling through the NF-kB and p38 MAPK pathway in a murine cementoblast cell line
- (2015) Neeracha Sanchavanakit et al. ARCHIVES OF ORAL BIOLOGY
- From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes
- (2015) Hae-Ok Byun et al. BMB Reports
- Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain
- (2015) Nicole Maphis et al. BRAIN
- Reactive Oxygen Species, Redox Signaling and Neuroinflammation in Alzheimer's Disease: The NF-κB Connection
- (2015) Upinder Kaur et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Depletion of microglia and inhibition of exosome synthesis halt tau propagation
- (2015) Hirohide Asai et al. NATURE NEUROSCIENCE
- pFTAA - a high affinity oligothiophene probe that detects filamentous tau in vivo and in cultured neurons
- (2015) AvivaM Tolkovsky et al. Neural Regeneration Research
- Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody
- (2015) Wenjie Luo et al. Scientific Reports
- Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures
- (2015) Sabine Hellwig et al. Scientific Reports
- The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice
- (2015) Jack Brelstaff et al. Frontiers in Neuroscience
- The active form of MMP-3 is a marker of synovial inflammation and cartilage turnover in inflammatory joint diseases
- (2014) Shu Sun et al. BMC MUSCULOSKELETAL DISORDERS
- Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury
- (2013) Kazutetsu Aoshiba et al. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
- Glial and Neuronal Tau Pathology in Tauopathies
- (2013) Isidre Ferrer et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Tau Pathology is Present In Vivo and Develops In Vitro in Sensory Neurons from Human P301S Tau Transgenic Mice: A System for Screening Drugs against Tauopathies
- (2013) M. Mellone et al. JOURNAL OF NEUROSCIENCE
- Tau pathology and neurodegeneration
- (2013) Maria Grazia Spillantini et al. LANCET NEUROLOGY
- Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology
- (2013) Grietje Krabbe et al. PLoS One
- Brain homogenates from human tauopathies induce tau inclusions in mouse brain
- (2013) Florence Clavaguera et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
- (2012) Alix de Calignon et al. NEURON
- Neuronal Death Induced by Nanomolar Amyloid β Is Mediated by Primary Phagocytosis of Neurons by Microglia
- (2011) Urte Neniskyte et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death
- (2011) J. J. Neher et al. JOURNAL OF IMMUNOLOGY
- Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease
- (2011) Xiao-dong Pan et al. Molecular Neurodegeneration
- Matrix metalloproteinases in peripheral blood and cerebrospinal fluid in patients with Alzheimer's disease
- (2010) Solveig Horstmann et al. INTERNATIONAL PSYCHOGERIATRICS
- CX3CR1 in Microglia Regulates Brain Amyloid Deposition through Selective Protofibrillar Amyloid- Phagocytosis
- (2010) Z. Liu et al. JOURNAL OF NEUROSCIENCE
- Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function
- (2010) eMalick G. Njie et al. NEUROBIOLOGY OF AGING
- Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease
- (2009) Wolfgang J. Streit et al. ACTA NEUROPATHOLOGICA
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now