Uncovering the universality of self-replication in protein aggregation and its link to disease

The role of clearance mechanisms in the kinetics of pathological protein aggregation involved in neurodegenerative diseases

(2021) T. B. Thompson et al.   JOURNAL OF CHEMICAL PHYSICS

Scaling analysis reveals the mechanism and rates of prion replication in vivo

(2021) Georg Meisl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells

(2021) Jason C. Sang et al.   Communications Biology

Proliferation of Tau 304–380 Fragment Aggregates through Autocatalytic Secondary Nucleation

(2021) Diana C. Rodriguez Camargo et al.   ACS Chemical Neuroscience

Uncovering Non-random Binary Patterns Within Sequences of Intrinsically Disordered Proteins

(2021) Megan C. Cohan et al.   JOURNAL OF MOLECULAR BIOLOGY

In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease

(2021) Georg Meisl et al.   Science Advances

Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates

(2021) Diana C. Rodriguez Camargo et al.   Frontiers in Molecular Biosciences

The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation

(2020) Georg Meisl et al.   CURRENT OPINION IN NEUROBIOLOGY

Life expectancy of parkinsonism patients in the general population

(2020) Lisanne J. Dommershuijsen et al.   PARKINSONISM & RELATED DISORDERS

The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils

(2020) Dev Thacker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-talk between individual phenol-soluble modulins in Staphylococcus aureus biofilm enables rapid and efficient amyloid formation

(2020) Masihuz Zaman et al.   eLife

Physical Determinants of Amyloid Assembly in Biofilm Formation

(2019) Maria Andreasen et al.   mBio

Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5–42

(2019) Tanja Weiffert et al.   ACS Chemical Neuroscience

Prion protein quantification in human cerebrospinal fluid as a tool for prion disease drug development

(2019) Sonia M. Vallabh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein strains target distinct brain regions and cell types

(2019) Angus Lau et al.   NATURE NEUROSCIENCE

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading

(2018) Franziska Kundel et al.   ACS Chemical Neuroscience

Secondary nucleation in amyloid formation

(2018) Mattias Törnquist et al.   CHEMICAL COMMUNICATIONS

Ecology and Biogenesis of Functional Amyloids in Pseudomonas

(2018) Sarah L. Rouse et al.   JOURNAL OF MOLECULAR BIOLOGY

Quantifying Nucleation In Vivo Reveals the Physical Basis of Prion-like Phase Behavior

(2018) Tarique Khan et al.   MOLECULAR CELL

Plasmodium falciparum msp1 and msp2 genetic diversity and allele frequencies in parasites isolated from symptomatic malaria patients in Bobo-Dioulasso, Burkina Faso

(2018) Anyirékun Fabrice Somé et al.   Parasites & Vectors

On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations

(2018) Xiaoting Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Origin of metastable oligomers and their effects on amyloid fibril self-assembly

(2018) Filip Hasecke et al.   Chemical Science

Physical basis of amyloid fibril polymorphism

(2018) William Close et al.   Nature Communications

Serum amyloid A – a review

(2018) George H. Sack   MOLECULAR MEDICINE

Extreme amyloid polymorphism in Staphylococcus aureus virulent PSMα peptides

(2018) Nir Salinas et al.   Nature Communications

Direct Observation of Murine Prion Protein Replication in Vitro

(2018) Jason C. Sang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Imperfect repeats in the functional amyloid protein FapC reduce the tendency to fragment during fibrillation

(2018) Casper B. Rasmussen et al.   PROTEIN SCIENCE

Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification

(2017) Ricardo Gaspar et al.   QUARTERLY REVIEWS OF BIOPHYSICS

The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril

(2017) Einav Tayeb-Fligelman et al.   SCIENCE

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants

(2017) Georg Meisl et al.   Chemical Science

Scaling behaviour and rate-determining steps in filamentous self-assembly

(2017) Georg Meisl et al.   Chemical Science

Effects of Protein Corona on IAPP Amyloid Aggregation, Fibril Remodelling, and Cytotoxicity

(2017) Emily H. Pilkington et al.   Scientific Reports

Causes of death and life span in Finnish gelsolin amyloidosis

(2016) Eeva-Kaisa Schmidt et al.   ANNALS OF MEDICINE

Natural supramolecular protein assemblies

(2016) Bas J. G. E. Pieters et al.   CHEMICAL SOCIETY REVIEWS

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model

(2016) Vaishali Kakkar et al.   MOLECULAR CELL

Molecular mechanisms of protein aggregation from global fitting of kinetic models

(2016) Georg Meisl et al.   Nature Protocols

Cell-Surface Phenol Soluble Modulins Regulate Staphylococcus aureus Colony Spreading

(2016) Hayato Kizaki et al.   PLoS One

Self-assembly of MPG1, a hydrophobin protein from the rice blast fungus that forms functional amyloid coatings, occurs by a surface-driven mechanism

(2016) Chi L. L. Pham et al.   Scientific Reports

The amyloid fold of Gad m 1 epitopes governs IgE binding

(2016) Rosa Sánchez et al.   Scientific Reports

Characterization of Amyloid Cores in Prion Domains

(2016) Ricardo Sant’Anna et al.   Scientific Reports

Secondary Crystal Nucleation: Nuclei Breeding Factory Uncovered

(2015) Jamshed Anwar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

On the lag phase in amyloid fibril formation

(2015) Paolo Arosio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Recombinant Human Semenogelin-1 (Sg1) and Sg1 (1-159) form Detergent Stable Amyloid like Aggregates in vitro

(2015) Neetu Sharma et al.   PROTEIN AND PEPTIDE LETTERS

A peptide from human semenogelin I self-assembles into a pH-responsive hydrogel

(2015) B. Frohm et al.   Soft Matter

Investigating the lytic activity and structural properties of Staphylococcus aureus phenol soluble modulin (PSM) peptide toxins

(2014) Maisem Laabei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structure of a Functional Amyloid Protein Subunit Computed Using Sequence Variation

(2014) Pengfei Tian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Quantification Assays for Total and Polyglutamine-Expanded Huntingtin Proteins

(2014) Douglas Macdonald et al.   PLoS One

Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis

(2014) J. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

(2014) Georg Meisl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

(2014) B. G. Wilhelm et al.   SCIENCE

CHANGE IN BLOOD GELSOLIN CONCENTRATION IN RESPONSE TO PHYSICAL EXERCISE

(2013) Chih-Chieh Yu et al.   BIOLOGY OF SPORT

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prions in Yeast

(2012) S. W. Liebman et al.   GENETICS

Pathogenic Serum Amyloid A 1.1 Shows a Long Oligomer-rich Fibrillation Lag Phase Contrary to the Highly Amyloidogenic Non-pathogenic SAA2.2

(2012) Saipraveen Srinivasan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation

(2012) Samuel I.A. Cohen et al.   JOURNAL OF MOLECULAR BIOLOGY

Yeast Colonies: A Model for Studies of Aging, Environmental Adaptation, and Longevity

(2012) Libuše Váchová et al.   Oxidative Medicine and Cellular Longevity

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Functional Amyloids Composed of Phenol Soluble Modulins Stabilize Staphylococcus aureus Biofilms

(2012) Kelly Schwartz et al.   PLoS Pathogens

Actin Structure and Function

(2011) Roberto Dominguez et al.   Annual Review of Biophysics

Inflammation Protein SAA2.2 Spontaneously Forms Marginally Stable Amyloid Fibrils at Physiological Temperature

(2011) Zhuqiu Ye et al.   BIOCHEMISTRY

Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments

(2011) Samuel I. A. Cohen et al.   JOURNAL OF CHEMICAL PHYSICS

Critical nucleus size for disease-related polyglutamine aggregation is repeat-length dependent

(2011) Karunakar Kar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heparin Induces Harmless Fibril Formation in Amyloidogenic W7FW14F Apomyoglobin and Amyloid Aggregation in Wild-Type Protein In Vitro

(2011) Silvia Vilasi et al.   PLoS One

Development and host cell modifications of Plasmodium falciparum blood stages in four dimensions

(2011) Christof Grüring et al.   Nature Communications

Actin Dynamics: From Nanoscale to Microscale

(2010) Anders E. Carlsson   Annual Review of Biophysics

Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice

(2010) Rong Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Direct visualization of secondary structures of F-actin by electron cryomicroscopy

(2010) Takashi Fujii et al.   NATURE

Deletion of a Ure2 C-terminal prion-inhibiting region promotes the rate of fibril seed formation and alters interaction with Hsp40

(2010) L. Chen et al.   PROTEIN ENGINEERING DESIGN & SELECTION

LIFE EXPECTANCY IN ALZHEIMER'S DISEASE (AD)

(2009) O. Zanetti et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

The 8 and 5 kDa Fragments of Plasma Gelsolin Form Amyloid Fibrils by a Nucleated Polymerization Mechanism, while the 68 kDa Fragment Is Not Amyloidogenic

(2009) James P. Solomon et al.   BIOCHEMISTRY

Defining and Characterizing the Progression of Type 2 Diabetes

(2009) V. A. Fonseca   DIABETES CARE

Plasmodium falciparum merozoite surface protein 2 is unstructured and forms amyloid-like fibrils

(2009) Christopher G. Adda et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The nature of the globular- to fibrous-actin transition

(2009) Toshiro Oda et al.   NATURE

Shear flow promotes amyloid-  fibrilization

(2009) D. E. Dunstan et al.   PROTEIN ENGINEERING DESIGN & SELECTION

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Structure and dynamics of cross-linked actin networks

(2009) Oliver Lieleg et al.   Soft Matter

Gelsolin concentration in cerebrospinal fluid from patients with multiple sclerosis and other neurological disorders

(2008) A. Kulakowska et al.   EUROPEAN JOURNAL OF NEUROLOGY

Treatment strategies for amyloid A amyloidosis

(2008) T Pettersson et al.   EXPERT OPINION ON PHARMACOTHERAPY

The Molecular Basis of Functional Bacterial Amyloid Polymerization and Nucleation

(2008) Xuan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY