A matter of time: study of circadian clocks and their role in inflammation

The circadian clock functions as a potent regulator of allergic reaction

(2015) A. Nakao et al.   ALLERGY

Suppression of atherosclerosis by synthetic REV-ERB agonist

(2015) Sadichha Sitaula et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Overexpression of circadian clock protein cryptochrome (CRY) 1 alleviates sleep deprivation-induced vascular inflammation in a mouse model

(2015) Bing Qin et al.   IMMUNOLOGY LETTERS

Overexpression of CRY1 protects against the development of atherosclerosis via the TLR/NF-κB pathway

(2015) Lei Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Melatonin regulates the rhythmic migration of neutrophils in live zebrafish

(2015) Da-long Ren et al.   JOURNAL OF PINEAL RESEARCH

Circadian control of innate immunity in macrophages by miR-155 targetingBmal1

(2015) Anne M. Curtis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clock gene expression in different synovial cells of patients with rheumatoid arthritis and osteoarthritis

(2014) Tatjana Becker et al.   ACTA HISTOCHEMICA

The rhythmic expression of clock genes attenuated in human plaque-derived vascular smooth muscle cells

(2014) Changpo Lin et al.   Lipids in Health and Disease

An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action

(2014) Julie Gibbs et al.   NATURE MEDICINE

REV-ERB and ROR nuclear receptors as drug targets

(2014) Douglas J. Kojetin et al.   NATURE REVIEWS DRUG DISCOVERY

Low-dose prednisone chronotherapy for rheumatoid arthritis: a randomised clinical trial (CAPRA-2)

(2013) Frank Buttgereit et al.   ANNALS OF THE RHEUMATIC DISEASES

Mice exposed to dim light at night exaggerate inflammatory responses to lipopolysaccharide

(2013) Laura K. Fonken et al.   BRAIN BEHAVIOR AND IMMUNITY

The circadian epigenome: how metabolism talks to chromatin remodeling

(2013) Lorena Aguilar-Arnal et al.   CURRENT OPINION IN CELL BIOLOGY

Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway

(2013) Jae-Woong Hwang et al.   FASEB JOURNAL

Environmental Circadian Disruption Elevates the IL-6 Response to Lipopolysaccharide in Blood

(2013) Kandis L. Adams et al.   JOURNAL OF BIOLOGICAL RHYTHMS

A Circadian Clock Gene, Rev-erb , Modulates the Inflammatory Function of Macrophages through the Negative Regulation of Ccl2 Expression

(2013) S. Sato et al.   JOURNAL OF IMMUNOLOGY

Optimized Chemical Probes for REV-ERBα

(2013) Ryan P. Trump et al.   JOURNAL OF MEDICINAL CHEMISTRY

The times they’re a-changing: Effects of circadian desynchronization on physiology and disease

(2013) Diego A. Golombek et al.   JOURNAL OF PHYSIOLOGY-PARIS

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

(2013) Michael T. Y. Lam et al.   NATURE

Circadian Timekeeping Is Disturbed in Rheumatoid Arthritis at Molecular Level

(2013) Vesa-Petteri Kouri et al.   PLoS One

Sleep Loss and the Inflammatory Response in Mice Under Chronic Environmental Circadian Disruption

(2013) Allison J. Brager et al.   PLoS One

Circadian clock regulates the host response to Salmonella

(2013) M. M. Bellet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Gene Bmal1 Regulates Diurnal Oscillations of Ly6Chi Inflammatory Monocytes

(2013) K. D. Nguyen et al.   SCIENCE

Uncoupling of Peripheral and Master Clock Gene Rhythms by Reversed Feeding Leads to an Exacerbated Inflammatory Response After Polymicrobial Sepsis in Mice

(2013) Yoshimasa Oyama et al.   SHOCK

The circadian clock and asthma

(2013) Hannah J Durrington et al.   THORAX

Increased Atherosclerotic Lesions in LDL Receptor Deficient Mice With Hematopoietic Nuclear Receptor Rev‐erbα Knock‐ Down

(2013) Hongling Ma et al.   Journal of the American Heart Association

Pharmacologic Repression of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γ Is Therapeutic in the Collagen-Induced Arthritis Experimental Model

(2013) Mi Ra Chang et al.   Arthritis & Rheumatology

Identification of SR2211: A Potent Synthetic RORγ-Selective Modulator

(2012) Naresh Kumar et al.   ACS Chemical Biology

Small molecule modifiers of circadian clocks

(2012) Zheng Chen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Circadian Clock Controls Toll-like Receptor 9-Mediated Innate and Adaptive Immunity

(2012) Adam C. Silver et al.   IMMUNITY

Chronic Shift-Lag Alters the Circadian Clock of NK Cells and Promotes Lung Cancer Growth in Rats

(2012) R. W. Logan et al.   JOURNAL OF IMMUNOLOGY

AMPK at the crossroads of circadian clocks and metabolism

(2012) Sabine D. Jordan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Timing to Perfection: The Biology of Central and Peripheral Circadian Clocks

(2012) Urs Albrecht   NEURON

Regulation of per and cry Genes Reveals a Central Role for the D-Box Enhancer in Light-Dependent Gene Expression

(2012) Philipp Mracek et al.   PLoS One

Core circadian protein CLOCK is a positive regulator of NF- B-mediated transcription

(2012) M. L. Spengler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines

(2012) R. Narasimamurthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Small Molecule Activators of Cryptochrome

(2012) T. Hirota et al.   SCIENCE

A Small Molecule Modulates Circadian Rhythms through Phosphorylation of the Period Protein

(2011) Jae Wook Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

It's time to swim! Zebrafish and the circadian clock

(2011) Gad Vatine et al.   FEBS LETTERS

Circadian clock gene Period2 regulates a time-of-day–dependent variation in cutaneous anaphylactic reaction

(2011) Yuki Nakamura et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening

(2011) Z. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The nuclear receptor REV-ERB  mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

(2011) J. E. Gibbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulation of Inflammatory Responses by Chronic Circadian Disruption

(2010) O. Castanon-Cervantes et al.   JOURNAL OF IMMUNOLOGY

Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

(2010) Q.-J. Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage Diversity and Polarization in Atherosclerosis

(2009) Alberto Mantovani et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mammalian Clock Gene Cryptochrome Regulates Arthritis via Proinflammatory Cytokine TNF- 

(2009) A. Hashiramoto et al.   JOURNAL OF IMMUNOLOGY

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

THE ABSENCE OF CIRCADIAN CUES DURING RECOVERY FROM SEPSIS MODIFIES PITUITARY-ADRENOCORTICAL FUNCTION AND IMPAIRS SURVIVAL

(2009) Drew E. Carlson et al.   SHOCK

Adverse effects of chronic circadian desynchronization in animals in a “challenging” environment

(2008) Fabian Preuss et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Overnight variations in cortisol, interleukin 6, tumour necrosis factor   and other cytokines in people with rheumatoid arthritis

(2008) M G Perry et al.   ANNALS OF THE RHEUMATIC DISEASES

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial

(2008) Frank Buttgereit et al.   LANCET

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3 

(2008) T. Hirota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological significance of a peripheral tissue circadian clock

(2008) K. A. Lamia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA