Article
Biology
Xiuxing Liu, Binyao Chen, Zhaohao Huang, Runping Duan, He Li, Lihui Xie, Rong Wang, Zhaohuai Li, Yuehan Gao, Yingfeng Zheng, Wenru Su
Summary: Poor sleep is associated with an imbalance in immune cells, increased autoimmune risks, decreased immune responses, susceptibility to infection and tumor development, as well as inflammation and cellular aging. These findings provide insights into the cellular and molecular mechanisms of pathologic conditions affected by poor sleep.
COMMUNICATIONS BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Guanxin Zhang, Qing Qin, Chen Zhang, Xiaobo Sun, Kyosuke Kazama, Bing Yi, Fang Cheng, Zhi-Fu Guo, Jianxin Sun
Summary: The study finds that NDRG1 plays an essential role in cell differentiation, proliferation, and stress responses. The expression of NDRG1 significantly increases in cytokine-stimulated endothelial cells and atherosclerotic lesions. Inhibition of NDRG1 not only suppresses the expression of procoagulant molecules but also exerts antithrombotic effects in endothelial cells, highlighting its potential as a therapeutic target for vascular diseases.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yang Bai, Long Zhang, Bin Zheng, Xinhua Zhang, Hong Zhang, Anning Zhao, Jing Yu, Zhan Yang, Jinkun Wen
Summary: circACTA2 derived from the smooth muscle alpha-actin gene regulates vascular smooth muscle cell (VSMC) phenotype and inflammation through the inhibition of NLRP3 inflammasome activation. Overexpression of circACTA2 reduces neointimal hyperplasia and inflammation induced by vascular injury by suppressing NF-kappa B-mediated transcription of NLRP3 gene and inhibiting inflammasome activation. Furthermore, circACTA2 inhibits VSMC pyroptosis and can be targeted to attenuate the expression of NLRP3, ASC, and caspase-1, providing a potential therapeutic strategy for vascular remodeling.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yuan-ru Zheng, Chun-lin Fan, Ye Chen, Jing-yu Quan, Ling-zhu Shi, Chun-yang Tian, Xiao Shang, Ni-shan Xu, Wen-cai Ye, Lin-zhong Yu, Jun-shan Liu
Summary: This study discovered that dammarane-type triterpenoid saponins from Panax notoginseng have anti-inflammatory, anti-angiogenetic, and anti-dengue virus effects. They may be developed as potential functional foods for treating inflammation, angiogenesis, and dengue-related diseases.
Article
Pharmacology & Pharmacy
Ji Hu, Ru Chen, Jie An, Yilong Wang, Minglu Liang, Kai Huang
Summary: The study demonstrates that dauricine can alleviate endothelial inflammation by suppressing the NF-κB pathway, leading to a decrease in adhesion of THP-1 cells to HUVECs and protection against acute lung injury in mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Paula Gonzalez-Lopez, Marta Alvarez-Villarreal, Ruben Ruiz-Simon, Andrea R. Lopez-Pastor, Melina Vega de Ceniga, Leticia Esparza, Jose L. Martin-Ventura, Oscar Escribano, Almudena Gomez-Hernandez
Summary: MicroRNAs miR-15a-5p and miR-199a-3p are significantly decreased in aortic and carotid samples from atherosclerosis patients and mice. Overexpression of these miRNAs can reduce inflammation and progression of atherosclerosis. MiR-15a-5p may serve as a novel diagnostic biomarker for advanced atherosclerosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Jia-Ni Yuan, Yu Hong, Zhuo-Lin Ma, Rui-Ping Pang, Qing-Qing Lei, Xiao-Fei Lv, Jia-Guo Zhou, Hui Huang, Ting-Ting Zhang
Summary: miR-302a acts as an effective suppressor of vascular inflammation by inhibiting the NF-kappa B pathway in endothelial cells, indicating its potential as a novel target for relieving vascular inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Xuan Li, Wanlu Xie, Qiong Pan, Xiaoxun Zhang, Liangjun Zhang, Nan Zhao, Qiaoling Xie, Jingjing Ding, Jin Chai
Summary: This study found that both SEMA7A mutation and overexpression can activate the NF-κB p50/p65 pathway through integrin beta 1 and play a crucial role in inflammatory responses.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Pharmacology & Pharmacy
Rongyin Gao, Ximei Zhang, Kun Zou, Duo Meng, Jinpeng Lv
Summary: Recent research indicates that clock proteins, specifically the protein CRY, play a role in regulating cutaneous pigmentation. The synthetic molecule modulator KL001 was found to inhibit melanin synthesis and reduce melanocyte dendrite elongation and melanosome transport. Activation of CRY1 led to the downregulation of MITF through the cAMP/PKA pathway, resulting in the inhibition of melanogenesis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Na Li, Guanjie Zhao, Mingzhu Xu
Summary: This study investigated the effects of Kluyveromyces marxianus on high-fat diet-induced kidney injury. The results showed that K. marxianus can have a beneficial effect on kidney injury by improving gut microbiota and inhibiting the activation of TLR4/NF-kappa B pathway.
CELLULAR MICROBIOLOGY
(2023)
Review
Immunology
Zhending Gan, Meiyu Zhang, Donghui Xie, Xiaoyan Wu, Changming Hong, Jian Fu, Lijuan Fan, Shengyi Wang, Sufang Han
Summary: Glycine, acting as an inhibitory neurotransmitter, not only affects the functions of macrophages but also shapes their polarization through cellular signaling pathways and microRNAs. Additionally, glycine has beneficial effects in preventing and treating macrophage-associated diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Hironori Nishitsuji, Satoko Iwahori, Mariko Ohmori, Kunitada Shimotohno, Takayuki Murata
Summary: This study reveals the molecular mechanisms behind the induction of proinflammatory cytokines by the SARS-CoV-2 virus. The NSP6 and ORF7a proteins activate the NF-kappa B pathway through interactions with TAK1. The polyubiquitination of NSP6 and ORF7a is essential for NF-kappa B activation, with TRIM13 and RNF121 playing key roles in this process. These findings provide novel insights into the pathogenesis of SARS-CoV-2 and the host immune response.
Article
Medicine, Research & Experimental
Weiwei Zhao, Huizhen Wei, Jun Lu, Wenjun Sha, Dusang Sun, Ting Pan, Tao Lei
Summary: The study aimed to investigate the regulatory effects of tyrosol on pro-inflammatory phenotypes. The results showed that tyrosol significantly inhibited cell adhesion, reduced cell migration, and decreased the release of pro-inflammatory factors and expression levels of adhesion-related molecules. These findings suggest that tyrosol could be a novel pharmacological approach for treating inflammatory vascular diseases.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Eun-Young Heo, Kyoung-Hee Lee, Jisu Woo, Jiyeon Kim, Chang-Hoon Lee, Kyung-Jin Lee, Yun-Kyu Kim, Chul-Gyu Yoo
Summary: This article investigates the role of CRBN in chronic obstructive pulmonary disease (COPD) pathogenesis. The study found that lower levels of CRBN protein were observed in COPD patients compared to never smokers and smokers. CRBN deficiency was shown to aggravate elastase-induced emphysematous changes and increase neutrophil infiltration, lung cell injury, and protein leakage into the bronchoalveolar space. Furthermore, CRBN deficiency led to elevated release of neutrophilic chemokines and inflammatory cytokines. The findings suggest that targeting CRBN could be an effective therapeutic approach for COPD treatment.
Article
Cell Biology
Enping Liu, Jiawei Sun, Jing Yang, Lin Li, Qili Yang, Jiuqin Zeng, Jiayu Zhang, Dahua Chen, Qinmiao Sun
Summary: ZDHHC11 positively regulates NF-kappa B signaling by promoting TRAF6 oligomerization and ligase activity, subsequently activating TAK1 and IKK complexes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)