Extensive CD4 and CD8 T Cell Cross-Reactivity between Alphaherpesviruses

HLA-A02:01–Restricted Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP11/12 Preferentially Recall Polyfunctional Effector Memory CD8+T Cells from Seropositive Asymptomatic Individuals and Protect Humanized HLA-A*02:01 Transgenic Mice against Ocular Herpes

(2015) Ruchi Srivastava et al.   JOURNAL OF IMMUNOLOGY

Zoster Vaccination Increases the Breadth of CD4+T Cells Responsive to Varicella Zoster Virus

(2015) Kerry J. Laing et al.   JOURNAL OF INFECTIOUS DISEASES

Updated, augmented vaccines compete with original antigenic sin

(2015) Shraddha Chakradhar   NATURE MEDICINE

Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults

(2015) Himal Lal et al.   NEW ENGLAND JOURNAL OF MEDICINE

CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo

(2015) Patrick J. Hanley et al.   Science Translational Medicine

Genetic variation in the HLA region is associated with susceptibility to herpes zoster

(2014) D R Crosslin et al.   GENES AND IMMUNITY

An Extensive Antigenic Footprint Underpins Immunodominant TCR Adaptability against a Hypervariable Viral Determinant

(2014) Usha K. Nivarthi et al.   JOURNAL OF IMMUNOLOGY

Molecular Basis of a Dominant T Cell Response to an HIV Reverse Transcriptase 8-mer Epitope Presented by the Protective Allele HLA-B*51:01

(2014) C. Motozono et al.   JOURNAL OF IMMUNOLOGY

Functional Characterization of Ocular-Derived Human Alphaherpesvirus Cross-Reactive CD4 T Cells

(2014) W. J. D. Ouwendijk et al.   JOURNAL OF IMMUNOLOGY

Altered Phenotype and Functionality of Varicella Zoster Virus–Specific Cellular Immunity in Individuals With Active Infection

(2014) David Schub et al.   JOURNAL OF INFECTIOUS DISEASES

Fold Rise in Antibody Titers by Measured by Glycoprotein-Based Enzyme-Linked Immunosorbent Assay Is an Excellent Correlate of Protection for a Herpes Zoster Vaccine, Demonstrated via the Vaccine Efficacy Curve

(2014) Peter B. Gilbert et al.   JOURNAL OF INFECTIOUS DISEASES

Virologic and Immunologic Evidence of Multifocal Genital Herpes Simplex Virus 2 Infection

(2014) C. Johnston et al.   JOURNAL OF VIROLOGY

Impact of Vaccination on the Epidemiology of Varicella: 1995-2009

(2014) R. Baxter et al.   PEDIATRICS

Broadly Reactive Human CD8 T Cells that Recognize an Epitope Conserved between VZV, HSV and EBV

(2014) Christopher Chiu et al.   PLoS Pathogens

Fever, Rash, and Systemic Symptoms: Understanding the Role of Virus and HLA in Severe Cutaneous Drug Allergy

(2014) Rebecca Pavlos et al.   Journal of Allergy and Clinical Immunology-In Practice

Examination of Links Between Herpes Zoster Incidence and Childhood Varicella Vaccination

(2013) Craig M. Hales et al.   ANNALS OF INTERNAL MEDICINE

Virus-Specific CD4+ Memory-Phenotype T Cells Are Abundant in Unexposed Adults

(2013) Laura F. Su et al.   IMMUNITY

Asymptomatic HLA-A*02:01-Restricted Epitopes from Herpes Simplex Virus Glycoprotein B Preferentially Recall Polyfunctional CD8+ T Cells from Seropositive Asymptomatic Individuals and Protect HLA Transgenic Mice against Ocular Herpes

(2013) X. Dervillez et al.   JOURNAL OF IMMUNOLOGY

Seroprevalence of Herpes Simplex Virus Types 1 and 2--United States, 1999-2010

(2013) H. Bradley et al.   JOURNAL OF INFECTIOUS DISEASES

High-throughput identification of antigen-specific TCRs by TCR gene capture

(2013) Carsten Linnemann et al.   NATURE MEDICINE

Local CD4 and CD8 T-Cell Reactivity to HSV-1 Antigens Documents Broad Viral Protein Expression and Immune Competence in Latently Infected Human Trigeminal Ganglia

(2013) Monique van Velzen et al.   PLoS Pathogens

Regression of Metastatic Merkel Cell Carcinoma Following Transfer of Polyomavirus-Specific T Cells and Therapies Capable of Reinducing HLA Class-I

(2013) A. G. Chapuis et al.   Cancer Immunology Research

T-cell receptor gene transfer exclusively to human CD8+ cells enhances tumor cell killing

(2012) Q. Zhou et al.   BLOOD

Epidemiology, Clinical Presentation, and Antibody Response to Primary Infection With Herpes Simplex Virus Type 1 and Type 2 in Young Women

(2012) David I. Bernstein et al.   CLINICAL INFECTIOUS DISEASES

Efficacy, Safety, and Tolerability of Herpes Zoster Vaccine in Persons Aged 50-59 Years

(2012) K. E. Schmader et al.   CLINICAL INFECTIOUS DISEASES

Clinical-grade varicella zoster virus-specific T cells produced for adoptive immunotherapy in hemopoietic stem cell transplant recipients

(2012) Emily Blyth et al.   CYTOTHERAPY

Cross-presentation and genome-wide screening reveal candidate T cells antigens for a herpes simplex virus type 1 vaccine

(2012) Lichen Jing et al.   JOURNAL OF CLINICAL INVESTIGATION

Peripheral Blood CD4 T-Cell and Plasmacytoid Dendritic Cell (pDC) Reactivity to Herpes Simplex Virus 2 and pDC Number Do Not Correlate with the Clinical or Virologic Severity of Recurrent Genital Herpes

(2012) Nicholas J. Moss et al.   JOURNAL OF VIROLOGY

CD4 T-Cell Memory Responses to Viral Infections of Humans Show Pronounced Immunodominance Independent of Duration or Viral Persistence

(2012) L. Jing et al.   JOURNAL OF VIROLOGY

The Attenuated Genotype of Varicella-Zoster Virus Includes an ORF0 Transitional Stop Codon Mutation

(2012) G. A. Peters et al.   JOURNAL OF VIROLOGY

Efficacy Results of a Trial of a Herpes Simplex Vaccine

(2012) Robert B. Belshe et al.   NEW ENGLAND JOURNAL OF MEDICINE

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire

(2012) D. A. Ostrov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

University of Washington Twin Registry: Poised for the Next Generation of Twin Research

(2012) Eric Strachan et al.   Twin Research and Human Genetics

Herpes Zoster Incidence Among Insured Persons in the United States, 1993–2006: Evaluation of Impact of Varicella Vaccination

(2011) Jessica Leung et al.   CLINICAL INFECTIOUS DISEASES

Herpes simplex virus type 2 and cancer: A medical geography approach

(2011) Frédéric Thomas et al.   INFECTION GENETICS AND EVOLUTION

Genital Shedding of Herpes Simplex Virus Among Symptomatic and Asymptomatic Persons With HSV-2 Infection

(2011) Elizabeth Tronstein   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A high-throughput single-cell analysis of human CD8+ T cell functions reveals discordance for cytokine secretion and cytolysis

(2011) Navin Varadarajan et al.   JOURNAL OF CLINICAL INVESTIGATION

Diversity in CD8+ T Cell Function and Epitope Breadth Among Persons with Genital Herpes

(2010) Kerry J. Laing et al.   JOURNAL OF CLINICAL IMMUNOLOGY

A flow cytometry-based assay to assess minute frequencies of CD8+ T cells by their cytolytic function

(2010) Jonas Stanke et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Applications for T-cell epitope queries and tools in the Immune Epitope Database and Analysis Resource

(2010) Yohan Kim et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Public TCR Use by Herpes Simplex Virus-2-Specific Human CD8 CTLs

(2010) L. Dong et al.   JOURNAL OF IMMUNOLOGY

Detailed Characterization of T Cell Responses to Herpes Simplex Virus-2 in Immune Seronegative Persons

(2010) C. M. Posavad et al.   JOURNAL OF IMMUNOLOGY

Varicella-Zoster Virus Glycoprotein E Is a Critical Determinant of Virulence in the SCID Mouse-Human Model of Neuropathogenesis

(2010) L. Zerboni et al.   JOURNAL OF VIROLOGY

The antigen-specific CD8+T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion

(2009) Catherine Haluszczak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Varicella‐Zoster Virus–Specific Immune Responses to Herpes Zoster in Elderly Participants in a Trial of a Clinically Effective Zoster Vaccine

(2009) Adriana Weinberg et al.   JOURNAL OF INFECTIOUS DISEASES

The Immune Epitope Database 2.0

(2009) Randi Vita et al.   NUCLEIC ACIDS RESEARCH