☆ 4.4 Article

Herpes simplex virus type 2 and cancer: A medical geography approach

INFECTION GENETICS AND EVOLUTION (2011)

期刊

INFECTION GENETICS AND EVOLUTION

卷 11, 期 6, 页码 1239-1242

出版社

ELSEVIER SCIENCE BV

DOI: 10.1016/j.meegid.2011.04.009

关键词

Genital herpes; Medical geography; Prostate cancer; Melanoma

类别

Infectious Diseases

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摘要

Herpes simplex virus type-2 (HSV-2) has been identified as a possible aetiological agent of cancer in humans, especially prostate cancer, but results remain controversial. Here, we have addressed this question using a medical geography approach based on the national incidence of various cancers and seroprevalence of HSV-2 in 64 countries worldwide. We corrected reports of cancer incidence for national gross domestic product (GDP) because living in a wealthy nation likely increases the probability of having a cancer detected. Data were also corrected for latitude and diet. Our analysis not only confirms that prostate cancer and HSV-2 seroprevalence are positively associated, but it also reveals the existence of a positive relationship between HSV-2 and melanoma incidence in both men and women. These results, though correlational, suggest that HSV-2 should continue to be investigated as a possible oncogenic pathogen of humans. (C) 2011 Elsevier B.V. All rights reserved.

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