Over-expression of LRIG1 suppresses biological function of pituitary adenoma via attenuation of PI3K/AKT and Ras/Raf/ERK pathways in vivo and in vitro

LRIG1, a 3p tumor suppressor, represses EGFR signaling and is a novel epigenetic silenced gene in colorectal cancer

(2015) Changhua Kou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LRIG1 inhibits hypoxia-induced vasculogenic mimicry formation via suppression of the EGFR/PI3K/AKT pathway and epithelial-to-mesenchymal transition in human glioma SHG-44 cells

(2015) Xi Zhang et al.   CELL STRESS & CHAPERONES

ErbB Receptor-Driven Prolactinomas Respond to Targeted Lapatinib Treatment in Female Transgenic Mice

(2015) Xiaohai Liu et al.   ENDOCRINOLOGY

Linc00152 promotes proliferation in gastric cancer through the EGFR-dependent pathway

(2015) Jianping Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PTPN11/Shp2 overexpression enhances liver cancer progression and predicts poor prognosis of patients

(2015) Tao Han et al.   JOURNAL OF HEPATOLOGY

LRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of basal-like breast cancer cells

(2015) N Yokdang et al.   ONCOGENE

By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis

(2015) Jiujiao Gao et al.   Oncotarget

Aggressive pituitary adenomas—diagnosis and emerging treatments

(2014) Antonio Di Ieva et al.   Nature Reviews Endocrinology

Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells

(2013) Ying Hu et al.   BIOCHEMICAL PHARMACOLOGY

LRIG1 modulates aggressiveness of head and neck cancers by regulating EGFR-MAPK-SPHK1 signaling and extracellular matrix remodeling

(2013) J J-C Sheu et al.   ONCOGENE

Downregulation of Insulin-like growth factor binding protein 6 is associated with ACTH-secreting pituitary adenoma growth

(2013) Yakun Yang et al.   Pituitary

EGFR as a therapeutic target for human, canine, and mouse ACTH-secreting pituitary adenomas

(2011) Hidenori Fukuoka et al.   JOURNAL OF CLINICAL INVESTIGATION

Association of expression of Leucine-rich repeats and immunoglobulin-like domains 2 gene with invasiveness of pituitary adenoma

(2011) Huaqiu Zhang et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Second AKT: The rise of SGK in cancer signalling

(2010) Maressa A. Bruhn et al.   GROWTH FACTORS

HER2/ErbB2 Receptor Signaling in Rat and Human Prolactinoma Cells: Strategy for Targeted Prolactinoma Therapy

(2010) Hidenori Fukuoka et al.   MOLECULAR ENDOCRINOLOGY

Upregulation of LRIG1 suppresses malignant glioma cell growth by attenuating EGFR activity

(2009) Fei Ye et al.   JOURNAL OF NEURO-ONCOLOGY

Rat Prolactinoma Cell Growth Regulation by Epidermal Growth Factor Receptor Ligands

(2008) G. Vlotides et al.   CANCER RESEARCH

LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII

(2008) M A Stutz et al.   ONCOGENE