Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone

Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone

(2021) Yunfei He et al.   Cell Death & Disease

Cell Biology of Giant Cell Tumour of Bone: Crosstalk between m/wt Nucleosome H3.3, Telomeres and Osteoclastogenesis

(2021) Ramses G. Forsyth et al.   Cancers

Immunohistochemical Characterization of Giant Cell Tumor of Bone Treated With Denosumab

(2020) Darcy A. Kerr et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass

(2020) Madison L. Doolittle et al.   PLoS Genetics

Drivers underpinning the malignant transformation of giant cell tumour of bone

(2020) Matthew W Fittall et al.   JOURNAL OF PATHOLOGY

Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression

(2020) Siddhant U. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone

(2020) Sima Khazaei et al.   Cancer Discovery

SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling

(2020) Yuh-Charn Lin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

(2020) Carol C.L. Chen et al.   CELL

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas

(2019) Brian Krug et al.   CANCER CELL

Absence of H3F3A mutation in a subset of malignant giant cell tumor of bone

(2019) Ken-ichi Yoshida et al.   MODERN PATHOLOGY

Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms

(2019) Natalie A. Sims et al.   Annual Review of Physiology

Giant cell tumours of bone treated with denosumab: histological, immunohistochemical and H3F3A mutation analyses

(2018) Ikuma Kato et al.   HISTOPATHOLOGY

AKAP11 gene polymorphism is associated with bone mass measured by quantitative ultrasound in young adults

(2018) María Correa-Rodríguez et al.   International Journal of Medical Sciences

Histone H3.3 G34 Mutations Alter Histone H3K36 and H3K27 Methylation In Cis

(2018) Leilei Shi et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma

(2018) Hsiao P. J. Voon et al.   Nature Communications

Targeting the MTF2-MDM2 axis sensitizes refractory acute myeloid leukemia to chemotherapy

(2018) Harinad B. Maganti et al.   Cancer Discovery

Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2

(2017) Philippa A Hulley et al.   JOURNAL OF PATHOLOGY

Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression ofSLC1A3andEPHB2

(2016) Carrie M Nielson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen

(2016) Susanne Scheipl et al.   JOURNAL OF PATHOLOGY

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

Data-driven hypothesis weighting increases detection power in genome-scale multiple testing

(2016) Nikolaos Ignatiadis et al.   NATURE METHODS

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

(2016) C. Lu et al.   SCIENCE

Histone variants: dynamic punctuation in transcription

(2014) C. M. Weber et al.   GENES & DEVELOPMENT

Multistage genome-wide association meta-analyses identified two new loci for bone mineral density

(2013) Lei Zhang et al.   HUMAN MOLECULAR GENETICS

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

(2013) Sam Behjati et al.   NATURE GENETICS

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma

(2013) P. W. Lewis et al.   SCIENCE

Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN

(2013) Lynn Bjerke et al.   Cancer Discovery

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Suppression of bone formation by osteoclastic expression of semaphorin 4D

(2011) Takako Negishi-Koga et al.   NATURE MEDICINE

SCUBE3 is an endogenous TGF-β receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer

(2011) Y-Y Wu et al.   ONCOGENE

Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study

(2010) David Thomas et al.   LANCET ONCOLOGY

Bone development and inflammatory disease is regulated by AP-1 (Fos/Jun)

(2009) E F Wagner   ANNALS OF THE RHEUMATIC DISEASES

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

(2009) Fernando Rivadeneira et al.   NATURE GENETICS

Multiple Genetic Loci for Bone Mineral Density and Fractures

(2008) Unnur Styrkarsdottir et al.   NEW ENGLAND JOURNAL OF MEDICINE