Cell Biology of Giant Cell Tumour of Bone: Crosstalk between m/wt Nucleosome H3.3, Telomeres and Osteoclastogenesis

Role of cancer stem cells in the development of giant cell tumor of bone

(2020) Abdul Rouf War et al.   Cancer Cell International

Drivers underpinning the malignant transformation of giant cell tumour of bone

(2020) Matthew W Fittall et al.   JOURNAL OF PATHOLOGY

H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone

(2020) Sima Khazaei et al.   Cancer Discovery

Histone Modifications and the Maintenance of Telomere Integrity

(2019) Meagan Jezek et al.   Cells

Adjuvant Zoledronic Acid in High‐Risk Giant Cell Tumor of Bone: A Multicenter Randomized Phase II Trial

(2019) Astrid Lipplaa et al.   ONCOLOGIST

Human osteogenic differentiation in Space: proteomic and epigenetic clues to better understand osteoporosis

(2019) Alessandra Gambacurta et al.   Scientific Reports

In situ cell cycle analysis in giant cell tumor of bone reveals patients with elevated risk of reduced progression-free survival

(2019) Mate E. Maros et al.   BONE

Denosumab in patients with giant-cell tumour of bone: a multicentre, open-label, phase 2 study

(2019) Sant Chawla et al.   LANCET ONCOLOGY

Mutation-driven epigenetic alterations as a defining hallmark of central cartilaginous tumours, giant cell tumour of bone and chondroblastoma

(2019) Sanne Venneker et al.   VIRCHOWS ARCHIV

Long interspersed element-1 ribonucleoprotein particles protect telomeric ends in alternative lengthening of telomeres dependent cells

(2019) Thomas Aschacher et al.   NEOPLASIA

Giant cell tumours of bone treated with denosumab: histological, immunohistochemical and H3F3A mutation analyses

(2018) Ikuma Kato et al.   HISTOPATHOLOGY

Histone H3.3 G34 Mutations Alter Histone H3K36 and H3K27 Methylation In Cis

(2018) Leilei Shi et al.   JOURNAL OF MOLECULAR BIOLOGY

TERRA recruitment of polycomb to telomeres is essential for histone trymethylation marks at telomeric heterochromatin

(2018) Juan J. Montero et al.   Nature Communications

Coupling of bone resorption and formation by RANKL reverse signalling

(2018) Yuki Ikebuchi et al.   NATURE

Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3–MutSα interaction

(2018) Jun Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection

(2018) Tracy T. Chow et al.   Nature Communications

The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

(2018) V. Barra et al.   Nature Communications

Engineering Lineage Potency and Plasticity of Stem Cells using Epigenetic Molecules

(2018) Anandika Dhaliwal et al.   Scientific Reports

H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells

(2018) Lijun Wang et al.   PLOS BIOLOGY

Giant cell tumour of bone in the denosumab era

(2017) Lizz van der Heijden et al.   EUROPEAN JOURNAL OF CANCER

Phenotypic and molecular differences between giant-cell tumour of soft tissue and its bone counterpart

(2017) Irene Mancini et al.   HISTOPATHOLOGY

Denosumab-treated giant cell tumor of bone. Its histologic spectrum and potential diagnostic pitfalls

(2017) Pablo Daniel Roitman et al.   HUMAN PATHOLOGY

Development of high-grade osteosarcoma in a patient with recurrent giant cell tumor of the ischium while receiving treatment with denosumab

(2017) Shinji Tsukamoto et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Choose Your Own Adventure: The Role of Histone Modifications in Yeast Cell Fate

(2017) Deepika Jaiswal et al.   JOURNAL OF MOLECULAR BIOLOGY

The histone variant H3.3 G34W substitution in giant cell tumor of the bone link chromatin and RNA processing

(2017) Jinyeong Lim et al.   Scientific Reports

Peptide drugs accelerate BMP-2-induced calvarial bone regeneration and stimulate osteoblast differentiation through mTORC1 signaling

(2016) Yasutaka Sugamori et al.   BIOESSAYS

Epigenetic Regulation of Bone Remodeling and Its Impacts in Osteoporosis

(2016) Chafik Ghayor et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas

(2016) D. Fang et al.   SCIENCE

H3K9me3-Dependent Heterochromatin: Barrier to Cell Fate Changes

(2016) Justin S. Becker et al.   TRENDS IN GENETICS

Regulation of the Human Telomerase Gene TERT by Telomere Position Effect—Over Long Distances (TPE-OLD): Implications for Aging and Cancer

(2016) Wanil Kim et al.   PLOS BIOLOGY

Neoadjuvant denosumab for extensive giant cell tumor in os ischium —a case report

(2015) Lizz van der Heijden et al.   Acta Orthopaedica

Mutation Analysis of H3F3A and H3F3B as a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma

(2015) Arjen H.G. Cleven et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation

(2015) Quanyuan He et al.   Cell Stem Cell

A High-grade Sarcoma Arising in a Patient With Recurrent Benign Giant Cell Tumor of the Proximal Tibia While Receiving Treatment With Denosumab

(2015) Luis A. Aponte-Tinao et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

SORBS2transcription is activated by telomere position effect–over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy

(2015) Jérôme D. Robin et al.   GENOME RESEARCH

Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres

(2015) Maheshi Udugama et al.   NUCLEIC ACIDS RESEARCH

TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization

(2015) Alessandra Galati et al.   NUCLEIC ACIDS RESEARCH

Prognostic Impact of Reduced Connexin43 Expression and Gap Junction Coupling of Neoplastic Stromal Cells in Giant Cell Tumor of Bone

(2015) Peter Balla et al.   PLoS One

RANKL/OPG; Critical role in bone physiology

(2015) T. John Martin et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Tenascin C in metastasis: A view from the invasive front

(2015) Camille M Lowy et al.   Cell Adhesion & Migration

Differential Expression of ADAM23, CDKN2A (P16), MMP14 and VIM Associated with Giant Cell Tumor of Bone

(2015) André Luis Giacometti Conceição et al.   Journal of Cancer

GATA4 negatively regulates osteoblast differentiation by downregulation of Runx2

(2014) Insun Song et al.   BMB Reports

Subnucleosomal Structures and Nucleosome Asymmetry across a Genome

(2014) Ho Sung Rhee et al.   CELL

Histone H3.3 Is Required to Maintain Replication Fork Progression after UV Damage

(2014) Alexander Frey et al.   CURRENT BIOLOGY

The long reach of telomeres: Figure 1.

(2014) Tom Misteli   GENES & DEVELOPMENT

Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances

(2014) Jérôme D. Robin et al.   GENES & DEVELOPMENT

Epigenetics of Aging and Aging-related Disease

(2014) A. Brunet et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Resolution of telomere associations by TRF1 cleavage in mouse embryonic stem cells

(2014) Kathleen Lisaingo et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes

(2014) Isabel López de Silanes et al.   Nature Communications

Transcription Recovery after DNA Damage Requires Chromatin Priming by the H3.3 Histone Chaperone HIRA

(2013) Salomé Adam et al.   CELL

Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span

(2013) L. Ashley Watson et al.   JOURNAL OF CLINICAL INVESTIGATION

Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: interim analysis of an open-label, parallel-group, phase 2 study

(2013) Sant Chawla et al.   LANCET ONCOLOGY

Modification of Enhancer Chromatin: What, How, and Why?

(2013) Eliezer Calo et al.   MOLECULAR CELL

Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency

(2013) Rupa Sridharan et al.   NATURE CELL BIOLOGY

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

(2013) Sam Behjati et al.   NATURE GENETICS

PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells

(2013) Fiona T. M. Chang et al.   NUCLEIC ACIDS RESEARCH

Telomeric repeats act as nucleosome-disfavouring sequences in vivo

(2013) Yuichi Ichikawa et al.   NUCLEIC ACIDS RESEARCH

Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma

(2013) P. W. Lewis et al.   SCIENCE

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

The chromatin remodeller ATRX: a repeat offender in human disease

(2013) David Clynes et al.   TRENDS IN BIOCHEMICAL SCIENCES

The G4 Genome

(2013) Nancy Maizels et al.   PLoS Genetics

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

Denosumab Induces Tumor Reduction and Bone Formation in Patients with Giant-Cell Tumor of Bone

(2012) D. G. Branstetter et al.   CLINICAL CANCER RESEARCH

Do Epigenetic Marks Govern Bone Mass and Homeostasis?

(2012) Jesus Delgado-Calle et al.   CURRENT GENOMICS

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

(2012) Gang Wu et al.   NATURE GENETICS

Nucleosome-depleted chromatin gaps recruit assembly factors for the H3.3 histone variant

(2012) J. I. Schneiderman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smooth muscle actin expression in primary bone tumours

(2012) F. Hemingway et al.   VIRCHOWS ARCHIV

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

(2012) Courtney A. Lovejoy et al.   PLoS Genetics

The double face of the histone variant H3.3

(2011) Emmanuelle Szenker et al.   CELL RESEARCH

The immunophenotype of osteoclasts and macrophage polykaryons

(2011) F. Maggiani et al.   JOURNAL OF CLINICAL PATHOLOGY

Dynamics of Histone H3 Deposition In Vivo Reveal a Nucleosome Gap-Filling Mechanism for H3.3 to Maintain Chromatin Integrity

(2011) Dominique Ray-Gallet et al.   MOLECULAR CELL

ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome

(2011) Shigeki Iwase et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Osteogenic growth peptide enhances the proliferation of bone marrow mesenchymal stem cells from osteoprotegerin-deficient mice by CDK2/cyclin A

(2010) Q. Fei et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Novel actions of bisphosphonates in bone: Preservation of osteoblast and osteocyte viability

(2010) Teresita Bellido et al.   BONE

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner

(2010) Martin J. Law et al.   CELL

Distinct Epigenomic Landscapes of Pluripotent and Lineage-Committed Human Cells

(2010) R. David Hawkins et al.   Cell Stem Cell

New functions for an old variant: no substitute for histone H3.3

(2010) Simon J Elsaesser et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Impaired mesenchymal stem cell differentiation and osteoclastogenesis in mice deficient for Igf2-P2 transcripts

(2010) S. N. Hardouin et al.   DEVELOPMENT

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3

(2010) P. Drane et al.   GENES & DEVELOPMENT

ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

(2010) L. H. Wong et al.   GENOME RESEARCH

Differential gene expression in classic giant cell tumours of bone: Tenascin C as biological risk factor for local relapses and metastases

(2010) Laura Pazzaglia et al.   HISTOPATHOLOGY

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

(2010) P. W. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Kinetics of Nucleosome Turnover Determined by Metabolic Labeling of Histones

(2010) R. B. Deal et al.   SCIENCE

Epigenetic regulation of telomere chromatin integrity in pluripotent embryonic stem cells

(2010) Lee H Wong   Epigenomics

Cytogenetic analysis of 101 giant cell tumors of bone: Nonrandom patterns of telomeric associations and other structural aberrations

(2009) Ludmila Gorunova et al.   GENES CHROMOSOMES & CANCER

Genomic instability in giant cell tumor of bone. A study of 52 cases using DNA ploidy, relocalization FISH, and array-CGH analysis

(2009) Linda Moskovszky et al.   GENES CHROMOSOMES & CANCER

Histone H3.3 incorporation provides a unique and functionally essential telomeric chromatin in embryonic stem cells

(2009) L. H. Wong et al.   GENOME RESEARCH

GJA1mutations, variants, and connexin 43 dysfunction as it relates to the oculodentodigital dysplasia phenotype

(2009) William A. Paznekas et al.   HUMAN MUTATION

Inducible Deposition of the Histone Variant H3.3 in Interferon-stimulated Genes

(2009) Tomohiko Tamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stable G-quadruplexes are found outside nucleosome-bound regions

(2009) Han Min Wong et al.   Molecular BioSystems

Genome-wide analysis predicts DNA structural motifs as nucleosome exclusion signals

(2009) Kangkan Halder et al.   Molecular BioSystems

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

Morphological and immunophenotypic features of primary and metastatic giant cell tumour of bone

(2009) M. Alberghini et al.   VIRCHOWS ARCHIV

New insights into the role of PML in tumour suppression

(2008) P Salomoni et al.   CELL RESEARCH

CD33+ CD14− Phenotype Is Characteristic of Multinuclear Osteoclast-Like Cells in Giant Cell Tumor of Bone

(2008) Ramses G Forsyth et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Telomere biology in giant cell tumour of bone

(2008) RG Forsyth et al.   JOURNAL OF PATHOLOGY