期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 430, 期 11, 页码 1562-1565出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2018.04.014
关键词
histone variant H3.3; G34 mutations; SETD2; giant cell tumor of the bone
资金
- NIH/NCI [CA204020]
- Cancer Prevention and Research Institute of Texas [RP160237]
- Welch Foundation [G1719]
- NIH [HG007538, CA193466]
- MD Anderson IRG [PS-100478]
Histone H3 encoding genes, particularly H3F3A and H3F3B, the genes encoding the variant histone H3.3, are mutated at high frequency in pediatric brain and bone malignancies. Compared to the extensive studies on K27M and K36M mutations, little is known about the mechanism of G34 mutations found in pediatric glioblastoma or giant cell tumors of the bone. Here we report that unlike the K27M or K36M that affect global histone methylation, the giant cell tumors of the bone G34 mutations (G34L/W) only affect histone H3K36 and H3K27 methylation on the same mutated histone tails (in cis), a mechanism distinct from known histone mutations. (C) 2018 Elsevier Ltd. All rights reserved.
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