期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 24, 页码 7196-7199出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201803663
关键词
asymmetric catalysis; boron; copper; fluorine; synthetic methods
资金
- Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) via the Program for Leading Graduate Schools (Hokkaido University Ambitious Leaders Program)
- Japan Society for the Promotion of Science via KAKENHI [15H03804, 18H03907]
The first catalytic enantioselective -boryl substitution of CF3-substituted alkenes is reported. A series of CF3-substituted alkenes was treated with a diboron reagent in the presence of a copper(I)/Josiphos catalyst to afford the corresponding optically active ,-gem-difluoroallylboronates in high enantioselectivity. The thus obtained products could be readily converted into the corresponding difluoromethylene-containing homoallylic alcohols using highly stereospecific allylation reactions.
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