Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4

Restoration of mitochondria function as a target for cancer therapy

(2015) Tariq A. Bhat et al.   DRUG DISCOVERY TODAY

Dual-targeting of aberrant glucose metabolism in glioblastoma

(2015) Han Shen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

Low copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in early-stage laryngeal cancer patients

(2014) Siwen Dang et al.   Diagnostic Pathology

Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties Contribute to Tumor Generation, Metastasis and Chemotherapy Resistance through Hypoxia-Resistant Metabolism

(2014) Jianqun Liao et al.   PLoS One

Differential Expression of Adenine Nucleotide Converting Enzymes in Mitochondrial Intermembrane Space: A Potential Role of Adenylate Kinase Isozyme 2 in Neutrophil Differentiation

(2014) Ayako Tanimura et al.   PLoS One

Pressing Mitochondrial Genetics Forward

(2014) Yu-Chan Chen et al.   Cell Reports

A Mitochondrial RNAi Screen Defines Cellular Bioenergetic Determinants and Identifies an Adenylate Kinase as a Key Regulator of ATP Levels

(2014) Nathan J. Lanning et al.   Cell Reports

Differential expression of adenylate kinase 4 in the context of disparate stress response strategies of HEK293 and HepG2 cells

(2013) Fanzhi Kong et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

ROS and Sympathetically Mediated Mitochondria Activation in Brown Adipose Tissue Contribute to Methamphetamine-Induced Hyperthermia

(2013) Manuel Sanchez-Alavez et al.   Frontiers in Endocrinology

NAD kinase regulates the size of the NADPH pool and insulin secretion in pancreatic β-cells

(2012) Joshua P. Gray et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma

(2012) Y-C Shen et al.   BRITISH JOURNAL OF CANCER

Adenylate Kinase-4 Is a Marker of Poor Clinical Outcomes That Promotes Metastasis of Lung Cancer by Downregulating the Transcription Factor ATF3

(2012) Y.-H. Jan et al.   CANCER RESEARCH

Rhythmic Nucleotide Synthesis in the Liver: Temporal Segregation of Metabolites

(2012) Jean-Michel Fustin et al.   Cell Reports

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Deferoxamine for Advanced Hepatocellular Carcinoma

(2011) Takahiro Yamasaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exploiting Mitochondrial Dysfunction for Effective Elimination of Imatinib-Resistant Leukemic Cells

(2011) Jérome Kluza et al.   PLoS One

Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis

(2010) Jennifer F Barger et al.   ENDOCRINE-RELATED CANCER

Localization of Adenylate Kinase 4 in Mouse Tissues

(2009) Keiko Miyoshi et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

Adenylate kinase isozyme 2 is essential for growth and development of Drosophila melanogaster

(2009) Koichi Fujisawa et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4

(2009) Christakis Panayiotou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase

(2008) Rujuan Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness

(2008) Chantal Lagresle-Peyrou et al.   NATURE GENETICS

Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2

(2008) Ulrich Pannicke et al.   NATURE GENETICS

Structure-function relationships in the 2-oxo acid dehydrogenase family: Substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins

(2007) Victoria I. Bunik et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS