Dual-targeting of aberrant glucose metabolism in glioblastoma

Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells

(2014) Allison B. Haugrud et al.   BREAST CANCER RESEARCH AND TREATMENT

Dichloroacetate induces autophagy in colorectal cancer cells and tumours

(2014) G Lin et al.   BRITISH JOURNAL OF CANCER

Targeting of two aspects of metabolism in breast cancer treatment

(2014) Bevan P Gang et al.   CANCER BIOLOGY & THERAPY

Sensitization of metformin-cytotoxicity by dichloroacetate via reprogramming glucose metabolism in cancer cells

(2014) Yong Won Choi et al.   CANCER LETTERS

Dichloroacetate Enhances Adriamycin-Induced Hepatoma Cell Toxicity In Vitro and In Vivo by Increasing Reactive Oxygen Species Levels

(2014) Yunhai Dai et al.   PLoS One

Mitochondria-targeted antioxidant and glycolysis inhibition

(2013) Archana Dilip et al.   ANTI-CANCER DRUGS

Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors

(2013) E. M. Dunbar et al.   INVESTIGATIONAL NEW DRUGS

A Metabolic Shift Favoring Sphingosine 1-Phosphate at the Expense of Ceramide Controls Glioblastoma Angiogenesis

(2013) Hazem J. Abuhusain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts

(2013) Krishan Kumar et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: A role of reorganized glucose metabolism, cell survival regulation and macrophage differentiation

(2013) Ajay Kumar et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase

(2012) Danielle Park et al.   Cancer Cell International

Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death

(2012) G. Cheng et al.   CANCER RESEARCH

HOT Models in Flux: Mitochondrial Glucose Oxidation Fuels Glioblastoma Growth

(2012) Paul S. Mischel   Cell Metabolism

Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo

(2012) Isaac Marin-Valencia et al.   Cell Metabolism

A dual-targeting hybrid platinum(iv) prodrug for enhancing efficacy

(2012) Haihua Xiao et al.   CHEMICAL COMMUNICATIONS

Bezielle Selectively Targets Mitochondria of Cancer Cells to Inhibit Glycolysis and OXPHOS

(2012) Vivian Chen et al.   PLoS One

Combination of Sulindac and Dichloroacetate Kills Cancer Cells via Oxidative Damage

(2012) Kasirajan Ayyanathan et al.   PLoS One

Bioenergetics Pathways and Therapeutic Resistance in Gliomas: Emerging Role of Mitochondria

(2011) Corinne E. Griguer et al.   CURRENT PHARMACEUTICAL DESIGN

Synergistic Antitumor Effect of Dichloroacetate in Combination with 5-Fluorouracil in Colorectal Cancer

(2011) Jingtao Tong et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells

(2011) Ramon C Sun et al.   Molecular Cancer

Mitochondrial Metabolism Inhibitors for Cancer Therapy

(2011) Emma E. Ramsay et al.   PHARMACEUTICAL RESEARCH

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma

(2011) Olivier Keunen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells

(2010) B M Madhok et al.   BRITISH JOURNAL OF CANCER

Selection of cancer cells with repressed mitochondria triggers colon cancer progression

(2010) María Sánchez-Aragó et al.   CARCINOGENESIS

Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC

(2010) Luke H. Stockwin et al.   INTERNATIONAL JOURNAL OF CANCER

Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?

(2010) Ioanna Papandreou et al.   INTERNATIONAL JOURNAL OF CANCER

γH2AX: a sensitive molecular marker of DNA damage and repair

(2010) L-J Mah et al.   LEUKEMIA

Sugar-free approaches to cancer cell killing

(2010) N El Mjiyad et al.   ONCOGENE

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism☆

(2009) Divya Pathania et al.   ADVANCED DRUG DELIVERY REVIEWS

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

(2009) Ramon C. Sun et al.   BREAST CANCER RESEARCH AND TREATMENT

Optimization of the Antitumor Efficacy of a Synthetic Mitochondrial Toxin by Increasing the Residence Time in the Cytosol

(2009) Pierre J. Dilda et al.   JOURNAL OF MEDICINAL CHEMISTRY

What is the mitochondrial permeability transition pore?

(2009) Andrew P. Halestrap   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype

(2009) Ad JC de Groof et al.   Molecular Cancer

Oxygen Consumption Can Regulate the Growth of Tumors, a New Perspective on the Warburg Effect

(2009) Yijun Chen et al.   PLoS One

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Dichloroacetate induces apoptosis in endometrial cancer cells

(2008) Jason Y.Y. Wong et al.   GYNECOLOGIC ONCOLOGY

Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells

(2008) Thomas McFate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From delocalized lipophilic cations to hypoxia: Blocking tumor cell mitochondrial function leads to therapeutic gain with glycolytic inhibitors

(2008) Metin Kurtoglu et al.   MOLECULAR NUTRITION & FOOD RESEARCH