The Mitochondrial HSP90 Paralog TRAP1: Structural Dynamics, Interactome, Role in Metabolic Regulation, and Inhibitors
出版年份 2022 全文链接
标题
The Mitochondrial HSP90 Paralog TRAP1: Structural Dynamics, Interactome, Role in Metabolic Regulation, and Inhibitors
作者
关键词
-
出版物
Biomolecules
Volume 12, Issue 7, Pages 880
出版商
MDPI AG
发表日期
2022-06-25
DOI
10.3390/biom12070880
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Enhanced Expression of TRAP1 Protects Mitochondrial Function in Motor Neurons under Conditions of Oxidative Stress
- (2022) Benjamin E. Clarke et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The mitochondrial chaperone TRAP1 regulates F-ATP synthase channel formation
- (2022) Giuseppe Cannino et al. CELL DEATH AND DIFFERENTIATION
- TRAP1 regulates the response of colorectal cancer cells to hypoxia and inhibits ribosome biogenesis under conditions of oxygen deprivation
- (2022) Giuseppina Bruno et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- The molecular chaperone TRAP1 in cancer: From the basics of biology to pharmacological targeting
- (2021) Ionica Masgras et al. SEMINARS IN CANCER BIOLOGY
- TRAP1 in Oxidative Stress and Neurodegeneration
- (2021) Inês Ramos Rego et al. Antioxidants
- TRAP1 inhibits MIC60 ubiquitination to mitigate the injury of cardiomyocytes and protect mitochondria in extracellular acidosis
- (2021) Lingxiao Zhang et al. Cell Death Discovery
- The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis
- (2020) Abhinav Joshi et al. BMC BIOLOGY
- Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug
- (2020) Sung Hu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Honokiol bis-dichloroacetate is a selective allosteric inhibitor of the mitochondrial chaperone TRAP1
- (2020) Carlos Sanchez-Martin et al. ANTIOXIDANTS & REDOX SIGNALING
- Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1
- (2020) Carlos Sanchez-Martin et al. Cell Reports
- Succinate Supplement Elicited “Pseudohypoxia” Condition to Promote Proliferation, Migration, and Osteogenesis of Periodontal Ligament Cells
- (2020) Huimin Mao et al. Stem Cells International
- Inhibition of HDAC1/2 Along with TRAP1 Causes Synthetic Lethality in Glioblastoma Model Systems
- (2020) Trang T. T. Nguyen et al. Cells
- Take Advantage of Glutamine Anaplerosis, the Kernel of the Metabolic Rewiring in Malignant Gliomas
- (2020) Filipa Martins et al. Biomolecules
- Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy
- (2020) Ana Belen Malpartida et al. TRENDS IN BIOCHEMICAL SCIENCES
- Interaction of germline variants in a family with a history of early‐onset clear cell renal cell carcinoma
- (2019) Emmanuelle Nicolas et al. Molecular Genetics & Genomic Medicine
- Hypoxia/pseudohypoxia‐mediated activation of hypoxia‐inducible factor‐1α in cancer
- (2019) Yoshihiro Hayashi et al. CANCER SCIENCE
- Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells
- (2019) Hye-Kyung Park et al. CANCER RESEARCH
- Impact of Mutations on NPAC Structural Dynamics: Mechanistic Insights from MD Simulations
- (2019) Marco Montefiori et al. Journal of Chemical Information and Modeling
- Hsp90 quaternary structures and the chaperone cycle: highly flexible dimeric and oligomeric structures and their regulation by co-chaperones
- (2018) Cyrille Garnier et al. Current Proteomics
- Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity
- (2018) Daniel Elnatan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Structural Asymmetry of Mitochondrial Hsp90 (Trap1) Determines Fine Tuning of Functional Dynamics
- (2018) Elisabetta Moroni et al. Journal of Chemical Theory and Computation
- Dancing with the Diva: Hsp90–Client Interactions
- (2018) Martina Radli et al. JOURNAL OF MOLECULAR BIOLOGY
- Overexpression of the mitochondrial chaperone tumor necrosis factor receptor‑associated protein 1 is associated with the poor prognosis of patients with colorectal cancer
- (2018) Chang Gao et al. Oncology Letters
- HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation
- (2018) Toshiki Kijima et al. Scientific Reports
- Mitochondria are physiologically maintained at close to 50 °C
- (2018) Dominique Chrétien et al. PLOS BIOLOGY
- TRAP1 ameliorates renal tubulointerstitial fibrosis in mice with unilateral ureteral obstruction by protecting renal tubular epithelial cell mitochondria
- (2017) Jun-Feng Chen et al. FASEB JOURNAL
- Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors
- (2017) Hye-Kyung Park et al. JOURNAL OF MEDICINAL CHEMISTRY
- The HSP90 chaperone machinery
- (2017) Florian H. Schopf et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mitochondrial matrix chaperone and c-myc inhibition causes enhanced lethality in glioblastoma
- (2017) Chiaki Tsuge Ishida et al. Oncotarget
- A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy
- (2017) Kelly G. Bryant et al. Oncotarget
- Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model
- (2017) Evangelia Vartholomaiou et al. Oncotarget
- Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1
- (2017) Daniel Elnatan et al. eLife
- Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis
- (2016) Laszlo Tretter et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors
- (2016) Gao Zhang et al. JOURNAL OF CLINICAL INVESTIGATION
- Mitochondrial Hsp90 is a ligand-activated molecular chaperone coupling ATP binding to dimer closure through a coiled-coil intermediate
- (2016) Nuri Sung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity inDrosophila
- (2016) Pedro Fernandez-Funez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis
- (2016) Marta Anna Kowalik et al. Oncotarget
- TRAP1 Provides Protection Against Myocardial Ischemia-Reperfusion Injury by Ameliorating Mitochondrial Dysfunction
- (2015) Peng Zhang et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Regulation and function of the human HSP90AA1 gene
- (2015) Abbey D. Zuehlke et al. GENE
- Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1
- (2015) Changwook Lee et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Hurt, tired and queasy: Specific variants in the ATPase domain of the TRAP1 mitochondrial chaperone are associated with common, chronic “functional” symptomatology including pain, fatigue and gastrointestinal dysmotility
- (2015) Richard G. Boles et al. MITOCHONDRION
- Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils
- (2015) Xuechao Gao et al. MOLECULAR CELL
- Impact of holdase chaperones Skp and SurA on the folding of β-barrel outer-membrane proteins
- (2015) Johannes Thoma et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Overexpression of tumor necrosis factor receptor-associated protein 1 (TRAP1) are associated with poor prognosis of epithelial ovarian cancer
- (2015) Qingjie Lv et al. TUMOR BIOLOGY
- Impact of holdase chaperones Skp and SurA on the folding of β-barrel outer-membrane proteins
- (2015) Johannes Thoma et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Aberrantly upregulated TRAP1 is required for tumorigenesis of breast cancer
- (2015) Bo Zhang et al. Oncotarget
- Lipophilic Triphenylphosphonium Cations Inhibit Mitochondrial Electron Transport Chain and Induce Mitochondrial Proton Leak
- (2015) Jan Trnka et al. PLoS One
- Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants
- (2015) Thomas L. Prince et al. PLoS One
- TRAP1 Shows Clinical Significance and Promotes Cellular Migration and Invasion through STAT3/MMP2 Pathway in Human Esophageal Squamous Cell Cancer
- (2014) Yunwei Ou et al. Journal of Genetics and Genomics
- Expression of TRAP1 Predicts Poor Survival of Malignant Glioma Patients
- (2014) Shuai Li et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Homozygous TRAP1 sequence variant in a child with Leigh syndrome and normal kidneys
- (2014) Stephanie J. Skinner et al. KIDNEY INTERNATIONAL
- Structural Asymmetry in the Closed State of Mitochondrial Hsp90 (TRAP1) Supports a Two-Step ATP Hydrolysis Mechanism
- (2014) Laura A. Lavery et al. MOLECULAR CELL
- Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells
- (2014) Andrea Rasola et al. TRENDS IN CELL BIOLOGY
- Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer
- (2014) Ru Chen WORLD JOURNAL OF GASTROENTEROLOGY
- Deletion of the Mitochondrial Chaperone TRAP-1 Uncovers Global Reprogramming of Metabolic Networks
- (2014) Sofia Lisanti et al. Cell Reports
- A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity
- (2014) James R Partridge et al. eLife
- Molecular Chaperone Functions in Protein Folding and Proteostasis
- (2013) Yujin E. Kim et al. Annual Review of Biochemistry
- The Mitochondrial Chaperone TRAP1 Promotes Neoplastic Growth by Inhibiting Succinate Dehydrogenase
- (2013) Marco Sciacovelli et al. Cell Metabolism
- TRAP1 rescues PINK1 loss-of-function phenotypes
- (2013) Li Zhang et al. HUMAN MOLECULAR GENETICS
- Whole-exome resequencing reveals recessive mutations in TRAP1 in individuals with CAKUT and VACTERL association
- (2013) Pawaree Saisawat et al. KIDNEY INTERNATIONAL
- Proteomic Differences Between Hepatocellular Carcinoma and Nontumorous Liver Tissue Investigated by a Combined Gel-based and Label-free Quantitative Proteomics Study
- (2013) Dominik A. Megger et al. MOLECULAR & CELLULAR PROTEOMICS
- Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis
- (2013) S. Yoshida et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson’s disease
- (2013) A C Costa et al. Cell Death & Disease
- Landscape of the mitochondrial Hsp90 metabolome in tumours
- (2013) Young Chan Chae et al. Nature Communications
- TRAP1 regulation of mitochondrial life or death decision in cancer cells and mitochondria-targeted TRAP1 inhibitors
- (2012) Byoung-Heon Kang BMB Reports
- Control of Tumor Bioenergetics and Survival Stress Signaling by Mitochondrial HSP90s
- (2012) Young Chan Chae et al. CANCER CELL
- TRAP1 Controls Mitochondrial Fusion/Fission Balance through Drp1 and Mff Expression
- (2012) Hironori Takamura et al. PLoS One
- Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity
- (2012) S. Tsutsumi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Correlation between mitochondrial TRAP-1 expression and lymph node metastasis in colorectal cancer
- (2012) Jing-Yan Gao WORLD JOURNAL OF GASTROENTEROLOGY
- The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity
- (2012) Erin K. Butler et al. PLoS Genetics
- GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum
- (2011) Michal Marzec et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Molecular chaperones in protein folding and proteostasis
- (2011) F. Ulrich Hartl et al. NATURE
- The Hexameric Structures of Human Heat Shock Protein 90
- (2011) Cheng-Chung Lee et al. PLoS One
- Preclinical Characterization of Mitochondria-Targeted Small Molecule Hsp90 Inhibitors, Gamitrinibs, in Advanced Prostate Cancer
- (2010) B. H. Kang et al. CLINICAL CANCER RESEARCH
- Mitochondrial chaperone tumour necrosis factor receptor-associated protein 1 protects cardiomyocytes from hypoxic injury by regulating mitochondrial permeability transition pore opening
- (2010) Fei Xiang et al. FEBS Journal
- Biochemical and Biophysical Characterization of the Mg2+-induced 90-kDa Heat Shock Protein Oligomers
- (2010) Laura Moullintraffort et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Heat Shock Response: Life on the Verge of Death
- (2010) Klaus Richter et al. MOLECULAR CELL
- HSP90 at the hub of protein homeostasis: emerging mechanistic insights
- (2010) Mikko Taipale et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Glutamine addiction: a new therapeutic target in cancer
- (2010) David R. Wise et al. TRENDS IN BIOCHEMICAL SCIENCES
- Cytoprotective Mitochondrial Chaperone TRAP-1 As a Novel Molecular Target in Localized and Metastatic Prostate Cancer
- (2009) Irwin Leav et al. AMERICAN JOURNAL OF PATHOLOGY
- Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3
- (2009) Martin Gamerdinger et al. EMBO JOURNAL
- Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90
- (2009) Byoung Heon Kang et al. JOURNAL OF CLINICAL INVESTIGATION
- BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90
- (2009) K. Lundgren et al. MOLECULAR CANCER THERAPEUTICS
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Targeting Mitochondria
- (2008) Adam T. Hoye et al. ACCOUNTS OF CHEMICAL RESEARCH
- Cancer Cell Metabolism: Warburg and Beyond
- (2008) Peggy P. Hsu et al. CELL
- The ATPase Cycle of the Mitochondrial Hsp90 Analog Trap1
- (2008) Adriane Leskovar et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Overexpression of Mitochondrial Hsp70/Hsp75 in Rat Brain Protects Mitochondria, Reduces Oxidative Stress, and Protects from Focal Ischemia
- (2008) Lijun Xu et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now