Uncovering Non-random Binary Patterns Within Sequences of Intrinsically Disordered Proteins

Glycine-Rich Peptides from FUS Have an Intrinsic Ability to Self-Assemble into Fibers and Networked Fibrils

(2021) Mrityunjoy Kar et al.   BIOCHEMISTRY

Valence and patterning of aromatic residues determine the phase behavior of prion-like domains

(2020) Erik W. Martin et al.   SCIENCE

Hydropathy Patterning Complements Charge Patterning to Describe Conformational Preferences of Disordered Proteins

(2020) Wenwei Zheng et al.   Journal of Physical Chemistry Letters

Making the Case for Disordered Proteins and Biomolecular Condensates in Bacteria

(2020) Megan C. Cohan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Phase separation by ssDNA binding protein controlled via protein−protein and protein−DNA interactions

(2020) Gábor M. Harami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ion Mobility Mass Spectrometry Uncovers the Impact of the Patterning of Oppositely Charged Residues on the Conformational Distributions of Intrinsically Disordered Proteins

(2019) Rebecca Beveridge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unfolded states under folding conditions accommodate sequence-specific conformational preferences with random coil-like dimensions

(2019) Ivan Peran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteome-wide signatures of function in highly diverged intrinsically disordered regions

(2019) Taraneh Zarin et al.   eLife

Information theoretic measures for quantifying sequence–ensemble relationships of intrinsically disordered proteins

(2019) Megan C Cohan et al.   PROTEIN ENGINEERING DESIGN & SELECTION

First-generation predictors of biological protein phase separation

(2019) Robert M Vernon et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Intrinsically disordered proteins access a range of hysteretic phase separation behaviors

(2019) Felipe Garcia Quiroz et al.   Science Advances

Regulation of Nearest-Neighbor Cooperative Binding of E. coli SSB Protein to DNA

(2019) Alexander G. Kozlov et al.   BIOPHYSICAL JOURNAL

Relationship of Sequence and Phase Separation in Protein Low-Complexity Regions

(2018) Erik W. Martin et al.   BIOCHEMISTRY

Convergence of Artificial Protein Polymers and Intrinsically Disordered Proteins

(2018) Michael Dzuricky et al.   BIOCHEMISTRY

Sequence charge decoration dictates coil-globule transition in intrinsically disordered proteins

(2018) Taylor Firman et al.   JOURNAL OF CHEMICAL PHYSICS

RGG/RG Motif Regions in RNA Binding and Phase Separation

(2018) P. Andrew Chong et al.   JOURNAL OF MOLECULAR BIOLOGY

Sequence-to-Conformation Relationships of Disordered Regions Tethered to Folded Domains of Proteins

(2018) Anuradha Mittal et al.   JOURNAL OF MOLECULAR BIOLOGY

Multisite dependency of an E3 ligase controls monoubiquitylation-dependent cell fate decisions

(2018) Achim Werner et al.   eLife

A High-Throughput Mutational Scan of an Intrinsically Disordered Acidic Transcriptional Activation Domain

(2018) Max V. Staller et al.   Cell Systems

The molecular language of membraneless organelles

(2018) Edward Gomes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Proteobacterial RNA Degradosomes Assemble Liquid-Liquid Phase-Separated RNP Bodies

(2018) Nadra Al-Husini et al.   MOLECULAR CELL

Structural Mechanisms of Cooperative DNA Binding by Bacterial Single-Stranded DNA-Binding Proteins

(2018) Katarzyna Dubiel et al.   JOURNAL OF MOLECULAR BIOLOGY

Glutamate promotes SSB protein–protein Interactions via intrinsically disordered regions

(2017) Alexander G. Kozlov et al.   JOURNAL OF MOLECULAR BIOLOGY

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics

(2017) Steven Boeynaems et al.   MOLECULAR CELL

Selection maintains signaling function of a highly diverged intrinsically disordered region

(2017) Taraneh Zarin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of transcriptional activity by design of charge patterning in the intrinsically disordered RAM region of the Notch receptor

(2017) Kathryn P. Sherry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The IDL ofE. coliSSB links ssDNA and protein binding by mediating protein-protein interactions

(2017) Piero R. Bianco et al.   PROTEIN SCIENCE

Sequence Determinants of the Conformational Properties of an Intrinsically Disordered Protein Prior to and upon Multisite Phosphorylation

(2016) Erik W. Martin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein

(2016) Chi W. Pak et al.   MOLECULAR CELL

Sequence-Specific Polyampholyte Phase Separation in Membraneless Organelles

(2016) Yi-Hsuan Lin et al.   PHYSICAL REVIEW LETTERS

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

Short linear motifs – ex nihilo evolution of protein regulation

(2015) Norman E. Davey et al.   Cell Communication and Signaling

Relating sequence encoded information to form and function of intrinsically disordered proteins

(2015) Rahul K Das et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Elastin-like polypeptides as models of intrinsically disordered proteins

(2015) Stefan Roberts et al.   FEBS LETTERS

A theoretical method to compute sequence dependent configurational properties in charged polymers and proteins

(2015) Lucas Sawle et al.   JOURNAL OF CHEMICAL PHYSICS

Intrinsically Disordered C-Terminal Tails of E . coli Single-Stranded DNA Binding Protein Regulate Cooperative Binding to Single-Stranded DNA

(2015) Alexander G. Kozlov et al.   JOURNAL OF MOLECULAR BIOLOGY

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

RNA degradosomes in bacteria and chloroplasts: classification, distribution and evolution of RNase E homologs

(2015) Soraya Aït-Bara et al.   MOLECULAR MICROBIOLOGY

Polymer physics of intracellular phase transitions

(2015) Clifford P. Brangwynne et al.   Nature Physics

Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck

(2015) Sudeep Banjade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An intrinsically disordered linker plays a critical role in bacterial cell division

(2015) P.J. Buske et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Functional Advantages of Conserved Intrinsic Disorder in RNA-Binding Proteins

(2015) Mihaly Varadi et al.   PLoS One

Short Linear Motifs: Ubiquitous and Functionally Diverse Protein Interaction Modules Directing Cell Regulation

(2014) Kim Van Roey et al.   CHEMICAL REVIEWS

RNase E in the γ-Proteobacteria: conservation of intrinsically disordered noncatalytic region and molecular evolution of microdomains

(2014) Soraya Aït-Bara et al.   MOLECULAR GENETICS AND GENOMICS

A quantitative measure for protein conformational heterogeneity

(2013) Nicholas Lyle et al.   JOURNAL OF CHEMICAL PHYSICS

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues

(2013) R. K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-scale prediction of proteins with long intrinsically disordered regions

(2013) Zhenling Peng et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Chemical composition is maintained in poorly conserved intrinsically disordered regions and suggests a means for their classification

(2012) Harry Amri Moesa et al.   Molecular BioSystems

A core subunit of Polycomb repressive complex 1 is broadly conserved in function but not primary sequence

(2012) L. Y. Beh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein disorder—a breakthrough invention of evolution?

(2011) Avner Schlessinger et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure of the SSB-DNA polymerase III interface and its role in DNA replication

(2011) Aimee H Marceau et al.   EMBO JOURNAL

Attributes of short linear motifs

(2011) Norman E. Davey et al.   Molecular BioSystems

Elastin-like polypeptides: Biomedical applications of tunable biopolymers

(2010) Sarah R. MacEwan et al.   BIOPOLYMERS

Elastomeric polypeptide-based biomaterials

(2010) Linqing Li et al.   Polymer Chemistry

Net charge per residue modulates conformational ensembles of intrinsically disordered proteins

(2010) A. H. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linking folding and binding

(2009) Peter E Wright et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Enzyme-mediated self-assembly of highly ordered structures from disordered proteins

(2009) Ahmad I Athamneh et al.   Smart Materials and Structures

SSB as an Organizer/Mobilizer of Genome Maintenance Complexes

(2008) Robert D. Shereda et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Determining Secondary Structure in Spider Dragline Silk by Carbon−Carbon Correlation Solid-State NMR Spectroscopy

(2008) Gregory P. Holland et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY