Melatonin promotes sirtuin 1 expression and inhibits IRE1α–XBP1S–CHOP to reduce endoplasmic reticulum stress–mediated apoptosis in chondrocytes

Melatonin Inhibits Glucose-Induced Apoptosis in Osteoblastic Cell Line Through PERK-eIF2α-ATF4 Pathway

(2021) Renyi Zhou et al.   Frontiers in Pharmacology

IRE1 signaling regulates chondrocyte apoptosis and death fate in the osteoarthritis

(2021) Rongxiang Huang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The ameliorative effect of terpinen-4-ol on ER stress-induced vascular calcification depends on SIRT1-mediated regulation of PERK acetylation

(2021) Yanyan Zhang et al.   PHARMACOLOGICAL RESEARCH

Long-term melatonin treatment attenuates body weight gain with aging in female mice

(2021) Isao Tamura et al.   JOURNAL OF ENDOCRINOLOGY

Quercetin ameliorates diabetic encephalopathy through SIRT1/ER stress pathway in db/db mfice

(2020) Tian Hu et al.   Aging-US

Mechanisms, regulation and functions of the unfolded protein response

(2020) Claudio Hetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SIRT1 directly activates autophagy in human chondrocytes

(2020) Pradeep K. Sacitharan et al.   Cell Death Discovery

Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation

(2020) Doo Ri Park et al.   Nature Communications

Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes

(2019) Feng Zhou et al.   Acta Pharmaceutica Sinica B

Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress

(2019) Guiping Luo et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Melatonin protects against COPD by attenuating apoptosis and endoplasmic reticulum stress via upregulating SIRT1 expression in rats

(2019) Baimei He et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Sirtuin-1 ameliorates cadmium-induced endoplasmic reticulum stress and pyroptosis through XBP-1s deacetylation in human renal tubular epithelial cells

(2019) Xin Chou et al.   ARCHIVES OF TOXICOLOGY

The role of sirtuin 1 and its activator, resveratrol in osteoarthritis

(2019) Zhenhan Deng et al.   BIOSCIENCE REPORTS

Cell death: a review of the major forms of apoptosis, necrosis and autophagy

(2019) Mark S D’Arcy   CELL BIOLOGY INTERNATIONAL

Melatonin Prevents Osteoarthritis-Induced Cartilage Degradation via Targeting MicroRNA-140

(2019) Yijian Zhang et al.   Oxidative Medicine and Cellular Longevity

Cartilage repair in degenerative osteoarthritis mediated by squid type II collagen via immunomodulating activation of M2 macrophages, inhibiting apoptosis and hypertrophy of chondrocytes

(2018) Meilu Dai et al.   BIOMATERIALS

Cardiac-Specific Overexpression of Silent Information Regulator 1 Protects Against Heart and Kidney Deterioration in Cardiorenal Syndrome via Inhibition of Endoplasmic Reticulum Stress

(2018) Dong Huang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The unknown face of IRE1α – Beyond ER stress

(2018) Ahmad Abdullah et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Sirtuin-1 (SIRT1) stimulates growth-plate chondrogenesis by attenuating the PERK–eIF-2α–CHOP pathway in the unfolded protein response

(2018) Xiaomin Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α

(2018) Denisse Sepulveda et al.   MOLECULAR CELL

SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons

(2018) David Romeo-Guitart et al.   Cell Death & Disease

Geniposide Alleviates Isoproterenol-Induced Cardiac Fibrosis Partially via SIRT1 Activation in vivo and in vitro

(2018) Ning Li et al.   Frontiers in Pharmacology

Baicalin suppresses IL-1β-induced expression of inflammatory cytokines via blocking NF-κB in human osteoarthritis chondrocytes and shows protective effect in mice osteoarthritis models

(2017) Chunhui Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival

(2017) Simon J. Tavernier et al.   NATURE CELL BIOLOGY

SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation

(2016) Alexandre Prola et al.   CELL DEATH AND DIFFERENTIATION

Melatonin Induces Anti-Inflammatory Effects to Play a Protective Role via Endoplasmic Reticulum Stress in Acute Pancreatitis

(2016) Yina Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Melatonin enhances interleukin-10 expression and suppresses chemotaxis to inhibit inflammation in situ and reduce the severity of experimental autoimmune encephalomyelitis

(2016) Shyi-Jou Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Melatonin modulates neonatal brain inflammation through endoplasmic reticulum stress, autophagy, and miR-34a/silent information regulator 1 pathway

(2016) Silvia Carloni et al.   JOURNAL OF PINEAL RESEARCH

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

Endoplasmic reticulum stress-mediated neuronal apoptosis by acrylamide exposure

(2016) Yuta Komoike et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Melatonin inhibits tunicamycin-induced endoplasmic reticulum stress and insulin resistance in skeletal muscle cells

(2015) Xiaojuan Quan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival

(2015) F Walter et al.   CELL DEATH AND DIFFERENTIATION

Effect of Melatonin on the Extracellular-Regulated Kinase Signal Pathway Activation and Human Osteoblastic Cell Line hFOB 1.19 Proliferation

(2015) Xiao-Chuan Xiong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy and protein kinase RNA-like endoplasmic reticulum kinase (PERK)/eukaryotic initiation factor 2 alpha kinase (eIF2α) pathway protect ovarian cancer cells from metformin-induced apoptosis

(2015) Hee-sun Moon et al.   MOLECULAR CARCINOGENESIS

Mitochondrial Biogenesis Is Impaired in Osteoarthritis Chondrocytes but Reversible via Peroxisome Proliferator-Activated Receptor γ Coactivator 1α

(2015) Yun Wang et al.   Arthritis & Rheumatology

Reduction of endoplasmic reticulum stress by 4-phenylbutyric acid prevents the development of hypoxia-induced pulmonary arterial hypertension

(2014) Masayuki Koyama et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review

(2014) Joaquín J. García et al.   JOURNAL OF PINEAL RESEARCH

Endoplasmic reticulum stress in cerebral ischemia

(2014) Qing Xin et al.   NEUROCHEMISTRY INTERNATIONAL

Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C/EBP homologous protein

(2014) Y. Uehara et al.   OSTEOARTHRITIS AND CARTILAGE

Functional Annotation of Rheumatoid Arthritis and Osteoarthritis Associated Genes by Integrative Genome-Wide Gene Expression Profiling Analysis

(2014) Zhan-Chun Li et al.   PLoS One

IRE1α dissociates with BiP and inhibits ER stress-mediated apoptosis in cartilage development

(2013) Xiaofeng Han et al.   CELLULAR SIGNALLING

Rescue of proinflammatory cytokine-inhibited chondrogenesis by the antiarthritic effect of melatonin in synovium mesenchymal stem cells via suppression of reactive oxygen species and matrix metalloproteinases

(2013) Xiaozhen Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Seven sirtuins for seven deadly diseases ofaging

(2012) Brian J. Morris   FREE RADICAL BIOLOGY AND MEDICINE

Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway

(2012) Hyun-Dae Lim et al.   JOURNAL OF PINEAL RESEARCH

Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction

(2011) J-H Ryu et al.   CELL DEATH AND DIFFERENTIATION

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

(2010) Feng-Ming Wang et al.   BIOCHEMICAL JOURNAL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions

(2010) Norifumi Fujita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Melatonin delays cell proliferation by inducing G1 and G2/M phase arrest in a human osteoblastic cell line hFOB 1.19

(2010) Lifeng Liu et al.   JOURNAL OF PINEAL RESEARCH

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes

(2008) Ming Pei et al.   JOURNAL OF PINEAL RESEARCH

The BMP antagonists follistatin and gremlin in normal and early osteoarthritic cartilage: an immunohistochemical study

(2008) G. Tardif et al.   OSTEOARTHRITIS AND CARTILAGE