Mitochondrial Biogenesis Is Impaired in Osteoarthritis Chondrocytes but Reversible via Peroxisome Proliferator-Activated Receptor γ Coactivator 1α

A time to reap, a time to sow: Mitophagy and biogenesis in cardiac pathophysiology

(2015) Allen M. Andres et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Peroxisome Proliferator-Activated Receptor γ Coactivator 1α and FoxO3A Mediate Chondroprotection by AMP-Activated Protein Kinase

(2014) Xianling Zhao et al.   Arthritis & Rheumatology

Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

(2013) Tokio Matsuzaki et al.   ANNALS OF THE RHEUMATIC DISEASES

Glucosamine Activates Autophagy In Vitro and In Vivo

(2013) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Towards elucidating the role of SirT1 in osteoarthritis

(2013) Mona Dvir-Ginzberg   Frontiers in Bioscience-Landmark

The role of mitochondria in aging

(2013) Ana Bratic et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacological approaches to restore mitochondrial function

(2013) Pénélope A. Andreux et al.   NATURE REVIEWS DRUG DISCOVERY

Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes

(2013) Freyr Petursson et al.   ARTHRITIS RESEARCH & THERAPY

Role of PGC-1α signaling in skeletal muscle health and disease

(2012) Chounghun Kang et al.   Annals of the New York Academy of Sciences

Mitochondrial dysfunction increases inflammatory responsiveness to cytokines in normal human chondrocytes

(2012) Carlos Vaamonde-García et al.   ARTHRITIS AND RHEUMATISM

Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2

(2012) Christos Gavriilidis et al.   ARTHRITIS AND RHEUMATISM

Effects of aging on articular cartilage homeostasis

(2012) Martin Lotz et al.   BONE

The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1β in human chondrocytes

(2012) Takehiko Matsushita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Autophagy: A New Therapeutic Target in Cartilage Injury and Osteoarthritis

(2012) Martin Lotz et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Mitochondrial electron transport and glycolysis are coupled in articular cartilage

(2012) J.A. Martin et al.   OSTEOARTHRITIS AND CARTILAGE

SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes

(2012) M.-H. Moon et al.   OSTEOARTHRITIS AND CARTILAGE

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes

(2011) Mona Dvir-Ginzberg et al.   ARTHRITIS AND RHEUMATISM

Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α

(2011) Robert Terkeltaub et al.   ARTHRITIS AND RHEUMATISM

75-kd sirtuin 1 blocks tumor necrosis factor α-mediated apoptosis in human osteoarthritic chondrocytes

(2011) Hanna Oppenheimer et al.   ARTHRITIS AND RHEUMATISM

The role of mitochondria in osteoarthritis

(2011) Francisco J. Blanco et al.   Nature Reviews Rheumatology

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1

(2010) Xiumei Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1: Regulation of longevity via autophagy

(2009) Antero Salminen et al.   CELLULAR SIGNALLING

Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression

(2009) Jolene Bohensky et al.   PEDIATRIC NEPHROLOGY

CK2 Is the Regulator of SIRT1 Substrate-Binding Affinity, Deacetylase Activity and Cellular Response to DNA-Damage

(2009) Hyeog Kang et al.   PLoS One

JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity

(2009) Nargis Nasrin et al.   PLoS One

The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production

(2008) Mandar Dave et al.   ARTHRITIS AND RHEUMATISM

Autophagy: A New Phase in the Maturation of Growth Plate Chondrocytes Is Regulated by HIF, mTOR and AMP Kinase

(2008) Vickram Srinivas et al.   CELLS TISSUES ORGANS

Regulation of Cartilage-specific Gene Expression in Human Chondrocytes by SirT1 and Nicotinamide Phosphoribosyltransferase

(2008) Mona Dvir-Ginzberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diminished mitochondrial DNA integrity and repair capacity in OA chondrocytes

(2008) V.I. Grishko et al.   OSTEOARTHRITIS AND CARTILAGE

Phosphorylation Regulates SIRT1 Function

(2008) Tsutomu Sasaki et al.   PLoS One

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA