Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer
出版年份 2022 全文链接
标题
Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer
作者
关键词
-
出版物
Nature Communications
Volume 13, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-08-08
DOI
10.1038/s41467-022-32135-0
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- IL-17A contributes to skeletal muscle atrophy in lung cancer-induced cachexia via JAK2/STAT3 pathway
- (2022) Lin Ying et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Effect of Bimagrumab vs Placebo on Body Fat Mass Among Adults With Type 2 Diabetes and Obesity
- (2021) Steven B. Heymsfield et al. JAMA Network Open
- Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
- (2021) Megan E. Rosa‐Caldwell et al. Journal of Cachexia Sarcopenia and Muscle
- Targeting the Activin Receptor Signaling to Counteract the Multi-Systemic Complications of Cancer and Its Treatments
- (2021) Juha J. Hulmi et al. Cells
- PPAR-alpha activation counters brown adipose tissue whitening: a comparative study between high-fat and high-fructose-fed mice
- (2020) Carolline Santos Miranda et al. NUTRITION
- Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia
- (2020) Sara Peixoto da Silva et al. Journal of Cachexia Sarcopenia and Muscle
- Management of Cancer Cachexia: ASCO Guideline
- (2020) Eric J. Roeland et al. JOURNAL OF CLINICAL ONCOLOGY
- Temperature but not leptin prevents semi-starvation induced hyperactivity in rats: implications for anorexia nervosa treatment
- (2020) Angela Fraga et al. Scientific Reports
- Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
- (2020) Michael A. Gillette et al. CELL
- BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control
- (2020) Christopher L Axelrod et al. EMBO Molecular Medicine
- Antibody-mediated inhibition of GDF15–GFRAL activity reverses cancer cachexia in mice
- (2020) Rowena Suriben et al. NATURE MEDICINE
- Brown fat does not cause cachexia in cancer patients: A large retrospective longitudinal FDG-PET/CT cohort study
- (2020) Anton S. Becker et al. PLoS One
- Characterization of cachexia in the human fibrosarcoma HT-1080 mouse tumour model
- (2020) Barbara Bernardo et al. Journal of Cachexia Sarcopenia and Muscle
- Sex Differences in Cancer Cachexia
- (2020) Xiaoling Zhong et al. Current Osteoporosis Reports
- Bimagrumab vs Optimized Standard of Care for Treatment of Sarcopenia in Community-Dwelling Older Adults
- (2020) Daniel Rooks et al. JAMA Network Open
- GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates
- (2020) Danna M. Breen et al. Cell Metabolism
- CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer
- (2020) Man Zhang et al. Nature Communications
- The regulatory approval of anamorelin for treatment of cachexia in patients with non‐small cell lung cancer, gastric cancer, pancreatic cancer, and colorectal cancer in Japan: facts and numbers.
- (2020) Hidetaka Wakabayashi et al. Journal of Cachexia Sarcopenia and Muscle
- A multicenter, open‐label, single‐arm study of anamorelin (ONO‐7643) in advanced gastrointestinal cancer patients with cancer cachexia
- (2019) Satoshi Hamauchi et al. CANCER
- Progress and challenges in analyzing rodent energy expenditure
- (2019) Rodrigo Fernández-Verdejo et al. NATURE METHODS
- Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging
- (2018) Leanne M. Redman et al. Cell Metabolism
- Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation
- (2018) Petra Kotzbeck et al. JOURNAL OF LIPID RESEARCH
- Calorie restriction regime enhances physical performance of trained athletes
- (2018) Victoria Pons et al. Journal of the International Society of Sports Nutrition
- Fenofibrate prevents skeletal muscle loss in mice with lung cancer
- (2018) Marcus D. Goncalves et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15
- (2018) Juli E. Jones et al. Cell Reports
- Treating cachexia using soluble ACVR2B improves survival, alters mTOR localization, and attenuates liver and spleen responses
- (2018) Tuuli A. Nissinen et al. Journal of Cachexia Sarcopenia and Muscle
- Three cachexia phenotypes and the impact of fat-only loss on survival in FOLFIRINOX therapy for pancreatic cancer
- (2018) Joshua K. Kays et al. Journal of Cachexia Sarcopenia and Muscle
- Cancer-associated cachexia
- (2018) Vickie E. Baracos et al. Nature Reviews Disease Primers
- BATLAS: Deconvoluting Brown Adipose Tissue
- (2018) Aliki Perdikari et al. Cell Reports
- GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
- (2017) Linda Yang et al. NATURE MEDICINE
- Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis
- (2017) L Jin et al. ONCOGENE
- A pathology atlas of the human cancer transcriptome
- (2017) Mathias Uhlen et al. SCIENCE
- Whitening and Impaired Glucose Utilization of Brown Adipose Tissue in a Rat Model of Type 2 Diabetes Mellitus
- (2017) Constantin Lapa et al. Scientific Reports
- Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia
- (2016) Justin L. Chen et al. CANCER RESEARCH
- Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity
- (2016) Thomas R. Flint et al. Cell Metabolism
- Key determinants of energy expenditure in cancer and implications for clinical practice
- (2016) S A Purcell et al. EUROPEAN JOURNAL OF CLINICAL NUTRITION
- Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
- (2016) Joshua D Campbell et al. NATURE GENETICS
- An AMP-activated protein kinase–stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice
- (2016) Maria Rohm et al. NATURE MEDICINE
- Models of energy homeostasis in response to maintenance of reduced body weight
- (2016) Michael Rosenbaum et al. Obesity
- ActRII blockade protects mice from cancer cachexia and prolongs survival in the presence of anti-cancer treatments
- (2016) Shinji Hatakeyama et al. Skeletal Muscle
- Complete reversal of muscle wasting in experimental cancer cachexia: Additive effects of activin type II receptor inhibition and β-2 agonist
- (2015) Míriam Toledo et al. INTERNATIONAL JOURNAL OF CANCER
- A Key Role for Leukemia Inhibitory Factor in C26 Cancer Cachexia
- (2015) Danielle N. Seto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of Activin A and Myostatin in Human Cancer Cachexia
- (2015) Audrey Loumaye et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- MAP3K11/GDF15 axis is a critical driver of cancer cachexia
- (2015) Lorena Lerner et al. Journal of Cachexia Sarcopenia and Muscle
- Plasma growth differentiation factor 15 is associated with weight loss and mortality in cancer patients
- (2015) Lorena Lerner et al. Journal of Cachexia Sarcopenia and Muscle
- Integration of body temperature into the analysis of energy expenditure in the mouse
- (2015) Gustavo Abreu-Vieira et al. Molecular Metabolism
- A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia
- (2014) Michele Petruzzelli et al. Cell Metabolism
- Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia
- (2014) Serkan Kir et al. NATURE
- Prognostic impact of cancer cachexia in patients with advanced non-small cell lung cancer
- (2014) Madoka Kimura et al. SUPPORTIVE CARE IN CANCER
- Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexia syndrome: preclinical profile
- (2014) Claudio Pietra et al. Journal of Cachexia Sarcopenia and Muscle
- Systematic evaluation of spliced alignment programs for RNA-seq data
- (2013) Pär G Engström et al. NATURE METHODS
- Effect of ghrelin and anamorelin (ONO-7643), a selective ghrelin receptor agonist, on tumor growth in a lung cancer mouse xenograft model
- (2013) R. Northrup et al. SUPPORTIVE CARE IN CANCER
- Blockade of the Activin Receptor IIB Activates Functional Brown Adipogenesis and Thermogenesis by Inducing Mitochondrial Oxidative Metabolism
- (2012) B. Fournier et al. MOLECULAR AND CELLULAR BIOLOGY
- A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue
- (2012) Min Yuan et al. Nature Protocols
- Estimation of Activity Related Energy Expenditure and Resting Metabolic Rate in Freely Moving Mice from Indirect Calorimetry Data
- (2012) Jan Bert Van Klinken et al. PLoS One
- Leptin synergizes with thyroid hormone signaling in promoting growth plate chondrocyte proliferation and terminal differentiation in vitro
- (2011) Lai Wang et al. BONE
- Cancer cachexia: A systematic literature review of items and domains associated with involuntary weight loss in cancer
- (2011) David Blum et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic–pituitary–adrenal axis
- (2011) Theodore P. Braun et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Definition and classification of cancer cachexia: an international consensus
- (2011) Kenneth Fearon et al. LANCET ONCOLOGY
- Caloric restriction
- (2011) John R. Speakman et al. MOLECULAR ASPECTS OF MEDICINE
- A guide to analysis of mouse energy metabolism
- (2011) Matthias H Tschöp et al. NATURE METHODS
- Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia
- (2011) S. K. Das et al. SCIENCE
- Cancer Causes Cardiac Atrophy and Autophagy in a Sexually Dimorphic Manner
- (2010) P. F. Cosper et al. CANCER RESEARCH
- Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival
- (2010) Xiaolan Zhou et al. CELL
- Characterization of the Ligand Binding Functionality of the Extracellular Domain of Activin Receptor Type IIB
- (2010) Dianne Sako et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- High levels of whole-body energy expenditure are associated with a lower coupling of skeletal muscle mitochondria in C57Bl/6 mice
- (2010) Sjoerd A.A. van den Berg et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Effects of experimental weight perturbation on skeletal muscle work efficiency, fuel utilization, and biochemistry in human subjects
- (2009) Rochelle Goldsmith et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Fat Metabolism During Exercise in Patients With Mitochondrial Disease
- (2009) Tina Dysgaard Jeppesen et al. ARCHIVES OF NEUROLOGY
- Arcuate Nucleus Proopiomelanocortin Neurons Mediate the Acute Anorectic Actions of Leukemia Inhibitory Factor via gp130
- (2009) Aaron J. Grossberg et al. ENDOCRINOLOGY
- Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteers
- (2009) José M. Garcia et al. GROWTH HORMONE & IGF RESEARCH
- The influence of age and sex on disease development in a novel animal model of cardiac cachexia
- (2009) Sandra Palus et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Sex differences in obesity and the regulation of energy homeostasis
- (2009) J. C. Lovejoy et al. Obesity Reviews
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