SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice

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Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice

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Mesenchymal Stromal Cell Secretome for Post-COVID-19 Pulmonary Fibrosis: A New Therapy to Treat the Long-Term Lung Sequelae?

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Protective efficacy of rhesus adenovirus COVID-19 vaccines against mouse-adapted SARS-CoV-2

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Senolytics reduce coronavirus-related mortality in old mice

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Unfolded Protein Response Inhibition Reduces Middle East Respiratory Syndrome Coronavirus-Induced Acute Lung Injury

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Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice

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Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity

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Lung Fibrosis after COVID-19: Treatment Prospects

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Pulmonary Pathology of End-Stage COVID-19 Disease in Explanted Lungs and Outcomes After Lung Transplantation

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Virus infection induced pulmonary fibrosis

(2021) Wei Jie Huang et al.   Journal of Translational Medicine

A humanized mouse model of chronic COVID-19

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Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients

(2021) Angélica Jayk Bernal et al.   NEW ENGLAND JOURNAL OF MEDICINE

A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus

(2021) William A. Fischer et al.   Science Translational Medicine

An interactive web-based dashboard to track COVID-19 in real time

(2020) Ensheng Dong et al.   LANCET INFECTIOUS DISEASES

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Too much stretching is bad for the lungs

(2020) Wei Wong   Science Signaling

Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review

(2020) Zheng Ye et al.   EUROPEAN RADIOLOGY

Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies

(2020) Sufang Tian et al.   MODERN PATHOLOGY

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

(2020) Timothy P. Sheahan et al.   Science Translational Medicine

COVID-19: a fast evolving pandemic

(2020) Jimmy Whitworth   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Pulmonary fibrosis secondary to COVID-19: a call to arms?

(2020) Paolo Spagnolo et al.   Lancet Respiratory Medicine

Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy

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Impact of Tregs on AT2 Cell Transcriptomes During Resolution of ALI and Contributions of IFN-γ

(2020) Jason R Mock et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

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(2020) Gabriel E Hoffman et al.   BIOINFORMATICS

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

(2020) Ahmed O. Hassan et al.   CELL

Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration

(2020) Jinwook Choi et al.   Cell Stem Cell

The Roles of Immune Cells in the Pathogenesis of Fibrosis

(2020) Enyu Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Persistent Symptoms in Patients After Acute COVID-19

(2020) Angelo Carfì et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

(2020) Benjamin Israelow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study

(2020) Luca Carsana et al.   LANCET INFECTIOUS DISEASES

A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression

(2020) Samuel B. Polak et al.   MODERN PATHOLOGY

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

(2020) Kizzmekia S. Corbett et al.   NATURE

Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis

(2020) Yoshihiko Kobayashi et al.   NATURE CELL BIOLOGY

Broad neutralization of SARS-related viruses by human monoclonal antibodies

(2020) Anna Z. Wec et al.   SCIENCE

Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

(2020) Maximilian Strunz et al.   Nature Communications

Quantification of Lung Fibrosis in IPF-Like Mouse Model and Pharmacological Response to Treatment by Micro-Computed Tomography

(2020) Francesca Ruscitti et al.   Frontiers in Pharmacology

Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network — United States, March–June 2020

(2020) Mark W. Tenforde et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis

(2020) Taylor S. Adams et al.   Science Advances

A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

(2020) Sarah R. Leist et al.   CELL

Progression to Fibrosing Diffuse Alveolar Damage in a Series of 30 Minimally Invasive Autopsies with COVID-19 Pneumonia in Wuhan, China

(2020) Yan Li et al.   HISTOPATHOLOGY

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

(2020) Kenneth H. Dinnon et al.   NATURE

Post-COVID-19 pneumonia pulmonary fibrosis

(2020) S Tale et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Fibrotic progression and radiologic correlation in matched lung samples from COVID-19 post-mortems

(2020) Emanuela Barisione et al.   VIRCHOWS ARCHIV

Two distinct immunopathological profiles in autopsy lungs of COVID-19

(2020) Ronny Nienhold et al.   Nature Communications

Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo

(2020) Alexandra Schäfer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

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Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection

(2020) Laurie G. Jacobs et al.   PLoS One

Lung transplantation for patients with severe COVID-19

(2020) Ankit Bharat et al.   Science Translational Medicine

Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection

(2020) Niyati Desai et al.   Nature Communications

Specificity, versatility, and control of TGF-β family signaling

(2019) Rik Derynck et al.   Science Signaling

The Collaborative Cross: A Systems Genetics Resource for Studying Host-Pathogen Interactions

(2019) Kelsey E. Noll et al.   Cell Host & Microbe

Organizing pneumonia secondary to influenza infection: Two case reports and a literature review

(2019) Andrea Nuñez-Conde et al.   ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA

Mouse Models as Resources for Studying Infectious Diseases

(2019) Sanjay Sarkar et al.   CLINICAL THERAPEUTICS

Nintedanib in Progressive Fibrosing Interstitial Lung Diseases

(2019) Kevin R. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Viral Infection Increases the Risk of Idiopathic Pulmonary Fibrosis

(2019) Gaohong Sheng et al.   CHEST

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MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape

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Impact of Cigarette Smoke Exposure on Lung Fibroblastic Response after Influenza Pneumonia

(2018) Sei Won Lee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Influenza A Virus Infection Causes Chronic Lung Disease Linked to Sites of Active Viral RNA Remnants

(2018) Shamus P. Keeler et al.   JOURNAL OF IMMUNOLOGY

Giving the Genes a Shuffle: Using Natural Variation to Understand Host Genetic Contributions to Viral Infections

(2018) Sarah R. Leist et al.   TRENDS IN GENETICS

Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways

(2018) Kenichi Okuda et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IL-33/ST2 Axis in Organ Fibrosis

(2018) Ourania S. Kotsiou et al.   Frontiers in Immunology

Respiratory syncytial virus infection accelerates lung fibrosis through the unfolded protein response in a bleomycin-induced pulmonary fibrosis animal model

(2017) Lina Wang et al.   Molecular Medicine Reports

Age-Dependent Susceptibility to Pulmonary Fibrosis Is Associated with NLRP3 Inflammasome Activation

(2016) Heather W. Stout-Delgado et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Persistent Pathology in Influenza-Infected Mouse Lungs

(2016) Cindy M. Kanegai et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

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A fast, sensitive, and high throughput method for the determination of nintedanib in mouse plasma by UPLC-MS/MS

(2015) Dan Xu et al.   Analytical Methods

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In Vivo Characterization of Alveolar and Interstitial Lung Macrophages in Rhesus Macaques: Implications for Understanding Lung Disease in Humans

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p63+Krt5+ distal airway stem cells are essential for lung regeneration

(2014) Wei Zuo et al.   NATURE

Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury

(2014) Andrew E. Vaughan et al.   NATURE

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

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Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

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Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses

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Advanced Heat Map and Clustering Analysis Using Heatmap3

(2014) Shilin Zhao et al.   Biomed Research International

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Flow Cytometric Analysis of Macrophages and Dendritic Cell Subsets in the Mouse Lung

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Expression of cilium-associated genes defines novel molecular subtypes of idiopathic pulmonary fibrosis

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Distal Airway Stem Cells Yield Alveoli In Vitro and during Lung Regeneration following H1N1 Influenza Infection

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