Article
Immunology
Carola Ledderose, Eleftheria-Angeliki Valsami, Mark Elevado, Wolfgang G. Junger
Summary: The study suggests that ATP release from the lungs of infected mice promotes influenza disease progression by priming peripheral neutrophils, which become strongly activated and cause pulmonary tissue damage after their recruitment to the lungs. This finding highlights ATP-induced neutrophil priming as a potential therapeutic target for reducing lung tissue damage in severe influenza cases.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Lei Guo, Nan Li, Zening Yang, Heng Li, Huiwen Zheng, Jinxi Yang, Yanli Chen, Xin Zhao, Junjie Mei, Haijing Shi, G. Scott Worthen, Longding Liu
Summary: The study found that by regulating the expression of the chemokine CXCL5, it can affect the accumulation of neutrophils and B lymphocytes in the lungs during pulmonary influenza infection, thereby altering the immune response to the virus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ni Zhao Wang, Xiang Sheng Yang, Jing Sun, Jin Cun Zhao, Nan Shan Zhong, Xiao Xiao Tang
Summary: This study evaluated the dynamics of lung responses during SARS-CoV-2 infection through transcriptome, proteome, and phosphoproteome analysis of lung tissues from a mouse model. The results showed the fluctuation of host responses and the alternation of signaling pathways and kinases regulating networks at different phases of infection. The study highlighted molecules and signaling pathways that could guide future investigations on COVID-19 therapies.
Article
Immunology
Xinying Zheng, Jianshu Guo, Chaoyue Cao, Tongtong Qin, Yue Zhao, Xiaolin Song, Meng Lv, Lingfei Hu, Lili Zhang, Dongsheng Zhou, Tongyu Fang, Wenhui Yang
Summary: This study established a mouse model of hvKp pneumonia and conducted a time-course transcriptional profile analysis of the lungs post-infection using RNA-Seq, revealing the gradual changes in the transcriptional profile reflecting disease progression.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stefanie Deinhardt-Emmer, Laura Jaeckel, Clio Haering, Sarah Boettcher, Janine J. Wilden, Brigitte Glueck, Regine Heller, Michaela Schmidtke, Mirijam Koch, Bettina Loeffler, Stephan Ludwig, Christina Ehrhardt
Summary: The PI3K inhibitor Pictilisib has been identified as a potent inhibitor of IV propagation, showing reduced viral titers and inflammatory response in the lungs, making it a promising candidate for anti-IV therapies. Repurposing previously approved substances is a cost-effective and efficient way for the development of novel antiviral strategies.
Article
Biochemistry & Molecular Biology
Yassin Elfaki, Juhao Yang, Julia Boehme, Kristin Schultz, Dunja Bruder, Christine S. Falk, Jochen Huehn, Stefan Floess
Summary: The research revealed that T cell subsets accumulation in IAV-infected lungs is transient, while the change in the ratio of CD4(+) to CD8(+) T cells is more durable. Tregs co-expressing T-bet peak at Day 7 post-infection, showing a strong demethylated characteristic.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Toxicology
Drew W. Svenson, Cameron J. Davidson, Chitra Thakur, Scott E. Bowen
Summary: This study assessed the pathological effects of acute inhaled toluene exposure on lung and brain tissues. The results showed that high concentrations of toluene exposure can induce inflammation and cellular damage in both lung and brain tissues.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Fabian Z. X. Lean, Ana Gomez Vitores, Scott M. Reid, Ashley C. Banyard, Ian H. Brown, Alejandro Nunez, Rowena D. E. Hansen
Summary: Highly pathogenic avian influenza virus has re-emerged in the UK and continues to have a global impact. This study investigates the pathological features of the virus in poultry and wild birds, identifying pancreatic and splenic necrosis as common findings.
Article
Plant Sciences
Yuan-zhen Hao, Li-feng Cen, Ting Wang, Tong Yi, Xun-long Shi, Hui-juan Duan, Zhi Dai, Hai-yan Zhu, Jian-guo Tang
Summary: This study investigated the therapeutic effect of 999 XiaoErGanMao granules (XEGMG) on lung and intestine injury in H1N1 influenza virus-infected mice. The results showed that XEGMG can mitigate body weight loss, reduce lung index and pathological damage, and decrease the release of inflammatory cytokines. XEGMG can also protect goblet cells in the colon, maintain intestinal barrier, and regulate the major flora.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Min Woo Kim, Byung Mook Weon, Jung Ho Je
Summary: By using synchrotron x-ray microtomography, we directly observed high-resolution 3D alveoli in live mice lungs and showed that they have spherical morphologies. Our measurements indicated that the alveoli in live lungs are spherical in shape, with low packing density, large size, and low osmotic pressure. In contrast, alveoli in fixed lungs appear polyhedral due to the confinement of alveolar clusters. The observation of spherical alveolar shapes will contribute to the understanding and treatment of lung diseases and ventilation.
SCIENTIFIC REPORTS
(2023)
Article
Veterinary Sciences
Nicolas Gaide, Marie-Noelle Lucas, Mattias Delpont, Guillaume Croville, Kim M. Bouwman, Andreas Papanikolaou, Roosmarijn van der Woude, Iwan A. Gagarinov, Geert-Jan Boons, Robert P. De Vries, Romain Volmer, Angelique Teillaud, Timothee Vergne, Celine Bleuart, Guillaume Le Loc'h, Maxence Delverdier, Jean-Luc Guerin
Summary: This study describes the pathobiological characteristics of the H5 highly pathogenic avian influenza outbreaks that occurred in Southwestern France in 2015-2016. The infection in chickens and guinea fowls was characterized by severe systemic vasculitis and parenchymal necrosis, while in ducks, the lesions were mild. Glycan-binding analyses revealed different affinities of the virus to the mucosae of different bird species, providing insights into its adaptability and transmission mechanisms.
VETERINARY RESEARCH
(2022)
Article
Cell Biology
William D. Green, Abrar E. Al-Shaer, Qing Shi, Kymberly M. Gowdy, Nancie J. MacIver, J. Justin Milner, Melinda A. Beck, Saame Raza Shaikh
Summary: The study suggests that diet-induced obesity may increase influenza virus pathogenesis through CD8(+) T cell-mediated metabolic reprogramming and impaired effector CD8(+) T cell function.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pengjing Lian, Yu Bai, Jingyun Li, Hongyan Wang, Xiaofei Niu, Zihui Zhang, Hongru Li, Lihong Zhao, Jian Qiao
Summary: The study revealed that H9N2 infection increased the expression levels of vitamin D metabolizing enzymes and vitamin D receptor in mouse lung tissues, indicating a potential role of vitamin D in the development and progression of avian influenza.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Riti Sharan, Shashank R. Ganatra, Dhiraj K. Singh, Journey Cole, Taylor W. Foreman, Rajesh Thippeshappa, Charles A. Peloquin, Vinay Shivanna, Olga Gonzalez, Cheryl L. Day, Neel R. Gandhi, Edward J. Dick, Shannan Hall-Ursone, Smriti Mehra, Larry S. Schlesinger, Jyothi Rengarajan, Deepak Kaushal
Summary: This study assessed the clearance of M. tuberculosis bacteria in macaques with asymptomatic LTBI following a three-month treatment of 3HP. The results showed that most of the treated macaques did not have persistent bacterial infection or extrapulmonary spread, while the untreated macaques harbored persistent bacterial infection and experienced tuberculosis reactivation following SIV coinfection. This suggests that 3HP treatment effectively reduces tuberculosis infection and prevents reactivation of latent tuberculosis in macaques.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, Research & Experimental
Riti Sharan, Shashank R. Ganatra, Dhiraj K. Singh, Journey Cole, Taylor W. Foreman, Rajesh Thippeshappa, Charles A. Peloquin, Vinay Shivanna, Olga Gonzalez, Cheryl L. Day, Neel R. Gandhi, Edward J. Dick Jr, Shannan Hall-Ursone, Smriti Mehra, Larry S. Schlesinger, Jyothi Rengarajan, Deepak Kaushal
Summary: The study found that 3HP treatment significantly reduced the infection of Mycobacterium tuberculosis and prevented reactivation of tuberculosis in latently infected macaques.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cell Biology
Ying Xi, Thomas Kim, Alexis N. Brumwell, Ian H. Driver, Ying Wei, Victor Tan, Julia R. Jackson, Jianming Xu, Dong-Kee Lee, Jeffrey E. Gotts, Michael A. Matthay, John M. Shannon, Harold A. Chapman, Andrew E. Vaughan
NATURE CELL BIOLOGY
(2017)
Article
Pathology
Li-Yin Hung, Taylor K. Oniskey, Debasish Sen, Matthew F. Krummel, Andrew E. Vaughan, Noam A. Cohen, De'Broski R. Herbert
AMERICAN JOURNAL OF PATHOLOGY
(2018)
Article
Multidisciplinary Sciences
Quy H. Nguyen, Nicholas Pervolarakis, Kerrigan Blake, Dennis Ma, Ryan Tevia Davis, Nathan James, Anh T. Phung, Elizabeth Willey, Raj Kumar, Eric Jabart, Ian Driver, Jason Rock, Andrei Goga, Seema A. Khan, Devon A. Lawson, Zena Werb, Kai Kessenbrock
NATURE COMMUNICATIONS
(2018)
Article
Immunology
Li-Yin Hung, Debasish Sen, Taylor K. Oniskey, Jeremey Katzen, Noam A. Cohen, Andrew E. Vaughan, Wildaliz Nieves, Anatoly Urisman, Michael F. Beers, Matthew F. Krummel, De'Broski R. Herbert
MUCOSAL IMMUNOLOGY
(2019)
Article
Physiology
Chetan K. Rane, Sergio R. Jackson, Christopher F. Pastore, Gan Zhao, Aaron Weiner, Neil N. Patel, De'Broski R. Herbert, Noam A. Cohen, Andrew E. Vaughan
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Snahlata Singh, Emily Elenio, Nicolae A. Leu, Rose-Anne Romano, Andrew E. Vaughan, Jennifer DeRiso, Kameswaran Surendran, Rumela Chakrabarti
Article
Immunology
Aeryon Kim, Chia-Jung Han, Ian Driver, Aleksandra Olow, Andrew K. Sewell, Zemin Zhang, Wenjun Ouyang, Jackson G. Egen, Xin Yu
JOURNAL OF IMMUNOLOGY
(2019)
Correction
Immunology
A. Kim, C. -J. Han, I. Driver, A. Olow, A. K. Sewell, Z. Zhang, W. Ouyang, J. G. Egen, X. Yu
JOURNAL OF IMMUNOLOGY
(2019)
Letter
Critical Care Medicine
Nilam S. Mangalmurti, John P. Reilly, Douglas B. Cines, Nuala J. Meyer, Christopher A. Hunter, Andrew E. Vaughan
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Review
Cell & Tissue Engineering
Maria Fernanda de Mello Costa, Aaron Weiner, Andrew E. Vaughan
Review
Biochemistry & Molecular Biology
Heather L. Rossi, Jorge F. Ortiz-Carpena, Devon Tucker, Andrew E. Vaughan, Nilam S. Mangalmurti, Noam A. Cohen, De'Broski R. Herbert
Summary: This review discusses the important role of TFF family members in healthy and diseased airways. TFF peptides maintain and restore homeostasis in the airways through their regulation of the mucous layer, cell motility, cell differentiation, and immune function. Differences in TFF member tracks between humans and mice pose a challenge for research. New evidence suggests that TFF proteins interact with receptor binding partners in mediating biological effects in mouse models of repair and infection. TFF peptides may be reasonable therapeutic targets in the treatment of airway diseases.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Sara Kass-Gergi, Andrew E. Vaughan
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Isabel Sierra, Sarah Pyfrom, Aaron Weiner, Gan Zhao, Amanda Driscoll, Xiang Yu, Brian D. Gregory, Andrew E. Vaughan, Montserrat C. Anguera
Summary: Sex differences in lung diseases, including COVID-19 and pulmonary fibrosis, may be influenced by the gene expression of the X-linked Ace2 gene in alveolar type 2 cells (AT2s), as well as the maintenance of X chromosome inactivation (XCI) in AT2s. A significant proportion of X-linked genes, including Ace2, escape XCI in AT2s, leading to genome-wide expression differences between male and female AT2s and potentially affecting lung physiology and pathological responses.
Article
Multidisciplinary Sciences
Gan Zhao, Aaron Weiner, Katherine M. Neupauer, Maria Fernanda de Mello Costa, Gargi Palashikar, Stephanie Adams-Tzivelekidis, Nilam S. Mangalmurti, Andrew E. Vaughan
Article
Cell & Tissue Engineering
Aaron Weiner, Sergio R. Jackson, Gan Zhao, Kwaku K. Quansah, Joseph N. Farshchian, Katherine M. Neupauer, Elizabeth Q. Littauer, Andrew J. Paris, Derek C. Liberti, G. Scott Worthen, Edward E. Morrisey, Andrew E. Vaughan
NPJ REGENERATIVE MEDICINE
(2019)
