Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid-Beta and Tau Aggregates in Alzheimer’s Disease

Tauvid™: The First FDA-Approved PET Tracer for Imaging Tau Pathology in Alzheimer’s Disease

(2021) Caitlin Jie et al.   Pharmaceuticals

In-vitro and in-vivo characterization of CRANAD-2 for multi-spectral optoacoustic tomography and fluorescence imaging of amyloid-beta deposits in Alzheimer mice

(2021) Ruiqing Ni et al.   Photoacoustics

Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of Alzheimer’s disease

(2020) Yash Pal Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In vivo Retinal Fluorescence Imaging With Curcumin in an Alzheimer Mouse Model

(2020) Ahmad Sidiqi et al.   Frontiers in Neuroscience

An insight into the in vivo imaging potential of curcumin analogues as fluorescence probes

(2020) Yu Liu et al.   Asian Journal of Pharmaceutical Sciences

Amyloid-β oligomer targeted theranostic probes for in vivo NIR imaging and inhibition of self-aggregation and amyloid-β induced ROS generation

(2020) Xueli Wang et al.   TALANTA

Rational Design of Near-Infrared AIE-Active Probes: In Situ Mapping of Amyloid-β Plaques with Ultra-Sensitivity and High-Fidelity

(2019) Wei Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alzheimer's “Prevention” vs. “Risk Reduction”: Transcending Semantics for Clinical Practice

(2019) John F. Hodes et al.   Frontiers in Neurology

Structure Based Design and Molecular Docking Studies for Phosphorylated Tau Inhibitors in Alzheimer’s Disease

(2019) Jangampalli Pradeepkiran et al.   Cells

Fluorescence Chemicals To Detect Insoluble and Soluble Amyloid-β Aggregates

(2019) Donghee Lee et al.   ACS Chemical Neuroscience

Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease

(2019) Piyoosh Sharma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer’s disease

(2019) Dylan Shea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative in vivo dual-color bioluminescence imaging in the mouse brain

(2019) Markus Aswendt et al.   Neurophotonics

Metal Ions in Alzheimer’s Disease: A Key Role or Not?

(2019) Yan Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Recent Developments in TSPO PET Imaging as A Biomarker of Neuroinflammation in Neurodegenerative Disorders

(2019) Eryn L. Werry et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Environment-Sensitive Near-Infrared Probe for Fluorescent Discrimination of Aβ and Tau Fibrils in AD Brain

(2019) Kaixiang Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vivo characterization of 18F-labeled difluoroboron-curcumin derivative for β-amyloid plaque imaging

(2019) Hyunjung Kim et al.   Scientific Reports

Identification of the Early Stage of Alzheimer's Disease Using Structural MRI and Resting-State fMRI

(2019) Seyed Hani Hojjati et al.   Frontiers in Neurology

A hemicyanine derivative for near-infrared imaging of β-amyloid plaques in Alzheimer's disease

(2019) Hua-Li Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A β-sheet-targeted theranostic agent for diagnosing and preventing aggregation of pathogenic peptides in Alzheimer’s disease

(2019) Xiang Ma et al.   Science China-Chemistry

Different aspects of Alzheimer’s disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia

(2019) Dietmar Rudolf Thal et al.   Acta Neuropathologica Communications

Development of Near-Infrared Fluorescent Probes for Use in Alzheimer’s Disease Diagnosis

(2019) Jian Yang et al.   BIOCONJUGATE CHEMISTRY

Novel D–A–D based near-infrared probes for the detection of β-amyloid and Tau fibrils in Alzheimer's disease

(2018) Yuying Li et al.   CHEMICAL COMMUNICATIONS

Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics

(2018) Shuqing He et al.   CHEMICAL SOCIETY REVIEWS

Shedding light on tau protein aggregation: the progress in developing highly selective fluorophores

(2018) Peter Verwilst et al.   CHEMICAL SOCIETY REVIEWS

Near-infrared Fluorescence Ocular Imaging (NIRFOI) of Alzheimer’s Disease

(2018) Jian Yang et al.   MOLECULAR IMAGING AND BIOLOGY

Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease

(2018) Kun Zhang et al.   Neural Regeneration Research

SPECT and PET imaging in Alzheimer’s disease

(2018) Varvara Valotassiou et al.   ANNALS OF NUCLEAR MEDICINE

Fluorescent Imaging of β-Amyloid Using BODIPY Based Near-Infrared Off–On Fluorescent Probe

(2018) Wenming Ren et al.   BIOCONJUGATE CHEMISTRY

Synthesis and evaluation of pyrazine and quinoxaline fluorophores for in vivo detection of cerebral tau tangles in Alzheimer's models

(2018) Biyue Zhu et al.   CHEMICAL COMMUNICATIONS

Paradigms in Fluorescence Molecular Imaging: Maximizing Measurement of Biological Changes in Disease, Therapeutic Efficacy, and Toxicology/Safety

(2018) Jeffrey D. Peterson   MOLECULAR IMAGING AND BIOLOGY

Solvation-Guided Design of Fluorescent Probes for Discrimination of Amyloids

(2018) Kevin J. Cao et al.   Scientific Reports

Molecular Imaging of β-Amyloid Plaques with Near-Infrared Boron Dipyrromethane (BODIPY)-Based Fluorescent Probes

(2018) Hiroyuki Watanabe et al.   Molecular Imaging

Comprehensive review of mechanisms of pathogenesis involved in Alzheimer’s disease and potential therapeutic strategies

(2018) Piyoosh Sharma et al.   PROGRESS IN NEUROBIOLOGY

A curcumin-based NIR fluorescence probe for detection of amyloid-beta (Aβ) plaques in Alzheimer's disease

(2018) Guofu Si et al.   DYES AND PIGMENTS

Targeting β-amyloid plaques and oligomers: development of near-IR fluorescence imaging probes

(2017) Hongwu Liu et al.   Future Medicinal Chemistry

cGMP production of the radiopharmaceutical [18 F]MK-6240 for PET imaging of human neurofibrillary tangles

(2017) Thomas Lee Collier et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Rational Design of in Vivo Tau Tangle-Selective Near-Infrared Fluorophores: Expanding the BODIPY Universe

(2017) Peter Verwilst et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Label-free brainwide visualization of senile plaque using cryo-micro-optical sectioning tomography

(2017) Yilin Luo et al.   OPTICS LETTERS

Oxalate-curcumin–based probe for micro- and macroimaging of reactive oxygen species in Alzheimer’s disease

(2017) Jian Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis and characterization of styryl-BODIPY derivatives for monitoring in vitro Tau aggregation

(2017) Vedamalai Mani et al.   SENSORS AND ACTUATORS B-CHEMICAL

A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies

(2017) Miranda E. Orr et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Fluoro-substituted cyanine for reliable in vivo labelling of amyloid-β oligomers and neuroprotection against amyloid-β induced toxicity

(2017) Yinhui Li et al.   Chemical Science

Tuning the stereo-hindrance of a curcumin scaffold for the selective imaging of the soluble forms of amyloid beta species

(2017) Yuyan Li et al.   Chemical Science

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

(2017) Rodrigo E. González-Reyes et al.   Frontiers in Molecular Neuroscience

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Why Women Have More Alzheimer's Disease Than Men: Gender and Mitochondrial Toxicity of Amyloid-β Peptide

(2017) Jose Viña et al.   JOURNAL OF ALZHEIMERS DISEASE

A Smart Near-Infrared Fluorescence Probe for Selective Detection of Tau Fibrils in Alzheimer’s Disease

(2016) Yujin Seo et al.   ACS Chemical Neuroscience

Ocular indicators of Alzheimer’s: exploring disease in the retina

(2016) Nadav J. Hart et al.   ACTA NEUROPATHOLOGICA

Advances in development of fluorescent probes for detecting amyloid-β aggregates

(2016) Ming-ming Xu et al.   ACTA PHARMACOLOGICA SINICA

Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients

(2016) Eric R. Siemers et al.   Alzheimers & Dementia

Dual PET and Near-Infrared Fluorescence Imaging Probes as Tools for Imaging in Oncology

(2016) Fei-Fei An et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Amyloid-β Deposits Target Efficient Near-Infrared Fluorescent Probes: Synthesis, in Vitro Evaluation, and in Vivo Imaging

(2016) Hualong Fu et al.   ANALYTICAL CHEMISTRY

A theranostic agent for in vivo near-infrared imaging of β-amyloid species and inhibition of β-amyloid aggregation

(2016) Yinhui Li et al.   BIOMATERIALS

Specific self-monitoring of metal-associated amyloid-β peptide disaggregation by a fluorescent chelator

(2016) Tao Yang et al.   CHEMICAL COMMUNICATIONS

A spiropyran-based fluorescent probe for the specific detection of β-amyloid peptide oligomers in Alzheimer's disease

(2016) Guanglei Lv et al.   CHEMICAL COMMUNICATIONS

Alzheimer's disease: Targeting the Cholinergic System

(2016) Talita H. Ferreira-Vieira et al.   Current Neuropharmacology

Multitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics

(2016) Michela Rosini et al.   Future Medicinal Chemistry

Clinical Positron Emission Tomography (PET) Neuroimaging: Advantages and Limitations as a Diagnostic Tool

(2016) Courtney Slough et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

(2016) Shanmugam Manoharan et al.   Oxidative Medicine and Cellular Longevity

Arterial Spin Labeling Perfusion of the Brain: Emerging Clinical Applications

(2016) Sven Haller et al.   RADIOLOGY

Imaging hydrogen peroxide in Alzheimer’s disease via cascade signal amplification

(2016) Jian Yang et al.   Scientific Reports

Gypenoside AttenuatesβAmyloid-Induced Inflammation in N9 Microglial Cells via SOCS1 Signaling

(2016) Hui Cai et al.   NEURAL PLASTICITY

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

(2016) Urmi Sengupta et al.   EBioMedicine

Molecular Mechanisms of Amyloid Oligomers Toxicity

(2016) Rakez Kayed et al.   JOURNAL OF ALZHEIMERS DISEASE

Fluselenamyl: A Novel Benzoselenazole Derivative for PET Detection of Amyloid Plaques (Aβ) in Alzheimer’s Disease

(2016) G. S. M. Sundaram et al.   Scientific Reports

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

Compromised MAPK signaling in human diseases: an update

(2015) Eun Kyung Kim et al.   ARCHIVES OF TOXICOLOGY

Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease

(2015) K. Rajasekhar et al.   CHEMICAL COMMUNICATIONS

The synthesis and evaluation of near-infrared probes with barbituric acid acceptors for in vivo detection of amyloid plaques

(2015) Kaixiang Zhou et al.   CHEMICAL COMMUNICATIONS

A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates

(2015) Hamid Shirani et al.   CHEMISTRY-A EUROPEAN JOURNAL

Current Practices in the Treatment of Alzheimer Disease: Where is the Evidence After the Phase III Trials?

(2015) Megan J. Ehret et al.   CLINICAL THERAPEUTICS

[18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer’s disease

(2015) Ryuichi Harada et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Compounds for imaging amyloid-β deposits in an Alzheimer’s brain: a patent review

(2015) Peiyu Tu et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Highly Sensitive Near-Infrared Fluorophores for in Vivo Detection of Amyloid-β Plaques in Alzheimer’s Disease

(2015) Hualong Fu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tau Assembly: The Dominant Role of PHF6 (VQIVYK) in Microtubule Binding Region Repeat R3

(2015) Pritam Ganguly et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Two-Photon Absorbing Dyes with Minimal Autofluorescence in Tissue Imaging: Application to in Vivo Imaging of Amyloid-β Plaques with a Negligible Background Signal

(2015) Dokyoung Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

(2015) Sagar H. Barage et al.   NEUROPEPTIDES

A curcumin-based molecular probe for near-infrared fluorescence imaging of tau fibrils in Alzheimer's disease

(2015) Kwang-su Park et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease

(2015) Xueli Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging Multimodalities for Dissecting Alzheimer's Disease: Advanced Technologies of Positron Emission Tomography and Fluorescence Imaging

(2015) Masafumi Shimojo et al.   Frontiers in Neuroscience

Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s disease

(2015) Hongjuan Tong et al.   Acta Pharmaceutica Sinica B

Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease

(2014) Yanli Tian et al.   CHEMICAL COMMUNICATIONS

Evaluation of molecules based on the electron donor–acceptor architecture as near-infrared β-amyloidal-targeting probes

(2014) Hualong Fu et al.   CHEMICAL COMMUNICATIONS

A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease

(2014) Xueli Zhang et al.   CHEMICAL COMMUNICATIONS

Pentameric Thiophene-Based Ligands that Spectrally Discriminate Amyloid-β and Tau Aggregates Display Distinct Solvatochromism and Viscosity-Induced Spectral Shifts

(2014) Rozalyn A. Simon et al.   CHEMISTRY-A EUROPEAN JOURNAL

Evaluation of the chorioretinal thickness changes in Alzheimer's disease using spectral-domain optical coherence tomography

(2014) Hasan Ali Bayhan et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Smart Near-Infrared Fluorescence Probes with Donor–Acceptor Structure for in Vivo Detection of β-Amyloid Deposits

(2014) Mengchao Cui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Guiding functional connectivity estimation by structural connectivity in MEG: an application to discrimination of conditions of mild cognitive impairment

(2014) José Angel Pineda-Pardo et al.   NEUROIMAGE

The effect of the water on the curcumin tautomerism: A quantitative approach

(2014) Yana Manolova et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Designing BODIPY-based probes for fluorescence imaging of β-amyloid plaques

(2014) Fazli Sozmen et al.   RSC Advances

Alzheimer's disease in the human eye. Clinical tests that identify ocular and visual information processing deficit as biomarkers

(2013) Lily Y.L. Chang et al.   Alzheimers & Dementia

Amyloid-β probes: Review of structure–activity and brain-kinetics relationships

(2013) Todd J Eckroat et al.   Beilstein Journal of Organic Chemistry

Two-photon fluorescence probes for imaging of mitochondria and lysosomes

(2013) Wanggui Yang et al.   CHEMICAL COMMUNICATIONS

Past and Recent Progress of Molecular Imaging Probes for β-Amyloid Plaques in the Brain

(2013) Mengchao Cui   CURRENT MEDICINAL CHEMISTRY

Antibody-conjugated, dual-modal, near-infrared fluorescent iron oxide nanoparticles for antiamyloidgenic activity and specific detection of amyloid-β fibrils

(2013) Shlomo Margel et al.   International Journal of Nanomedicine

Changes in Brain Function Occur Years before the Onset of Cognitive Impairment

(2013) L. L. Beason-Held et al.   JOURNAL OF NEUROSCIENCE

Appropriate Use Criteria for Amyloid PET: A Report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association

(2013) K. A. Johnson et al.   JOURNAL OF NUCLEAR MEDICINE

Design and Synthesis of Curcumin Analogues for in Vivo Fluorescence Imaging and Inhibiting Copper-Induced Cross-Linking of Amyloid Beta Species in Alzheimer’s Disease

(2013) Xueli Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Immunotherapy for Alzheimer’s disease: hoops and hurdles

(2013) Cynthia A Lemere   Molecular Neurodegeneration

Tau phosphorylation affects its axonal transport and degradation

(2013) Teresa Rodríguez-Martín et al.   NEUROBIOLOGY OF AGING

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

(2013) Masahiro Maruyama et al.   NEURON

Brain Imaging in Alzheimer Disease

(2013) K. A. Johnson et al.   Cold Spring Harbor Perspectives in Medicine

Alzheimer’s Disease Diagnosis by Detecting Exogenous Fluorescent Signal of Ligand Bound to Beta Amyloid in the Lens of Human Eye: An Exploratory Study

(2013) Charles Kerbage et al.   Frontiers in Neurology

BODIPY-Based Molecular Probe for Imaging of Cerebral β-Amyloid Plaques

(2012) Masahiro Ono et al.   ACS Chemical Neuroscience

2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer’s disease

(2012) Jiamin Gu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fluorescent and Colorimetric Probes for Mercury(II): Tunable Structures of Electron Donor and π-Conjugated Bridge

(2012) Xiaohong Cheng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Using PET with 18F-AV-45 (florbetapir) to quantify brain amyloid load in a clinical environment

(2012) V. Camus et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines As Imaging Agents for Tau Fibrils and β-Amyloid Plaques in Alzheimer’s Disease Models

(2012) Alexander Boländer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aminonaphthalene 2-Cyanoacrylate (ANCA) Probes Fluorescently Discriminate between Amyloid-β and Prion Plaques in Brain

(2012) Kevin Cao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Benzothiazole Schiff-bases as potential imaging agents for β-amyloid plaques in Alzheimer’s disease

(2012) Changsheng Gan et al.   MEDICINAL CHEMISTRY RESEARCH

Making the Brain Glow: In Vivo Bioluminescence Imaging to Study Neurodegeneration

(2012) Katja Hochgräfe et al.   MOLECULAR NEUROBIOLOGY

From inherited to sporadic AD—crossing the biomarker bridge

(2012) Harald Hampel et al.   Nature Reviews Neurology

The retina as a window to the brain—from eye research to CNS disorders

(2012) Anat London et al.   Nature Reviews Neurology

Visual contrast sensitivity in Alzheimer’s disease, mild cognitive impairment, and older adults with cognitive complaints

(2012) Shannon L. Risacher et al.   NEUROBIOLOGY OF AGING

Mitochondria-Specific Accumulation of Amyloid β Induces Mitochondrial Dysfunction Leading to Apoptotic Cell Death

(2012) Moon-Yong Cha et al.   PLoS One

Dicyanovinylnaphthalenes for neuroimaging of amyloids and relationships of electronic structures and geometries to binding affinities

(2012) A. Petric et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The β-Amyloid Hypothesis in Alzheimer's Disease: Seeing Is Believing

(2012) Hank F. Kung   ACS Medicinal Chemistry Letters

A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer’s and Prion Diseases

(2012) Matteo Staderini et al.   ACS Medicinal Chemistry Letters

ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue

(2011) Willy M. Chang et al.   ACS Chemical Neuroscience

Bivalent Ligand Containing Curcumin and Cholesterol as a Fluorescence Probe for Aβ Plaques in Alzheimer’s Disease

(2011) Kai Liu et al.   ACS Chemical Neuroscience

Inhibition of Beta-Amyloid Peptide Aggregation by Multifunctional Carbazole-Based Fluorophores

(2011) Wanggui Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tau-targeted treatment strategies in Alzheimer's disease

(2011) Jürgen Götz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Amyloid β peptide oligomers directly activate NMDA receptors

(2011) Laura Texidó et al.   CELL CALCIUM

Optical probes and the applications in multimodality imaging

(2011) Yang Liu et al.   Contrast Media & Molecular Imaging

Brain Activity Patterns in Stable and Progressive Mild Cognitive Impairment During Working Memory as Evidenced by Magnetoencephalography

(2011) Fernando Maestú et al.   JOURNAL OF CLINICAL NEUROPHYSIOLOGY

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

In vivo detection of amyloid β deposition using 19F magnetic resonance imaging with a 19F-containing curcumin derivative in a mouse model of Alzheimer's disease

(2011) D. Yanagisawa et al.   NEUROSCIENCE

Synthesis of a library of oligothiophenes and their utilization as fluorescent ligands for spectral assignment of protein aggregates

(2011) Therése Klingstedt et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Neurodegenerative disease biomarkers: Guideposts for disease prevention through early diagnosis and intervention

(2011) John Q. Trojanowski et al.   PROGRESS IN NEUROBIOLOGY

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Fluorescence Molecular Tomography: Principles and Potential for Pharmaceutical Research

(2011) Florian Stuker et al.   Pharmaceutics

Effects of Congo Red on Aβ1−40 Fibril Formation Process and Morphology

(2010) Partha Pratim Bose et al.   ACS Chemical Neuroscience

A Single Ascending Dose Study of Bapineuzumab in Patients With Alzheimer Disease

(2010) Ronald S. Black et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

The Insatiable Quest for Near-Infrared Fluorescent Probes for Molecular Imaging

(2010) Samuel Achilefu   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of dual functional SPECT/fluorescent probes for imaging cerebral β-amyloid plaques

(2010) Masahiro Ono et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

REVIEW: Curcumin and Alzheimer's Disease

(2010) Tsuyoshi Hamaguchi et al.   CNS Neuroscience & Therapeutics

In Vivo Imaging of Amyloid Deposition in Alzheimer Disease Using the Radioligand 18F-AV-45 (Flobetapir F 18)

(2010) D. F. Wong et al.   JOURNAL OF NUCLEAR MEDICINE

Cognitive deficits and associated neurological complications in individuals with Down's syndrome

(2010) Ira T Lott et al.   LANCET NEUROLOGY

11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

(2010) Juha O Rinne et al.   LANCET NEUROLOGY

Copper(i) and copper(ii) binding to β-amyloid 16 (Aβ16) studied by electrospray ionization mass spectrometry

(2010) Yu Lu et al.   Metallomics

Neuropathology of Alzheimer's Disease

(2010) Daniel P. Perl   MOUNT SINAI JOURNAL OF MEDICINE

Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model

(2010) Maya Koronyo-Hamaoui et al.   NEUROIMAGE

Tau protein and tau aggregation inhibitors

(2010) Bruno Bulic et al.   NEUROPHARMACOLOGY

Novel Pentameric Thiophene Derivatives forin Vitroandin VivoOptical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses

(2009) Andreas Åslund et al.   ACS Chemical Biology

Development of Tau Aggregation Inhibitors for Alzheimer's Disease

(2009) Bruno Bulic et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The effect of curcumin (turmeric) onAlzheimer′s disease: An overview

(2009) Shrikant Mishra et al.   Annals of Indian Academy of Neurology

Push–pull benzothiazole derivatives as probes for detecting β-amyloid plaques in Alzheimer’s brains

(2009) Masahiro Ono et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Compensation of optical heterogeneity-induced artifacts in fluorescence molecular tomography: theory and in vivo validation

(2009) Pouyan Mohajerani et al.   JOURNAL OF BIOMEDICAL OPTICS

Photophysics, photochemistry and photobiology of curcumin: Studies from organic solutions, bio-mimetics and living cells

(2009) K. Indira Priyadarsini   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS

Synthesis of a BODIPY Library and Its Application to the Development of Live Cell Glucagon Imaging Probe

(2009) Jun-Seok Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorescent BODIPY-Based Zn(II) Complex as a Molecular Probe for Selective Detection of Neurofibrillary Tangles in the Brains of Alzheimer’s Disease Patients

(2009) Akio Ojida et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, Synthesis, and Testing of Difluoroboron-Derivatized Curcumins as Near-Infrared Probes for in Vivo Detection of Amyloid-β Deposits

(2009) Chongzhao Ran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: Effects on axonal viability

(2009) Laura Gasparini et al.   NEUROBIOLOGY OF AGING

Vascular risk factors and dementia: How to move forward?

(2009) A. Viswanathan et al.   NEUROLOGY

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Studies of Copper(I) Complexes of Amyloid-β Peptide Fragments: Formation of Two-Coordinate Bis(histidine) Complexes

(2008) Richard A. Himes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Near-infrared fluorescent probes for imaging vascular pathophysiology

(2008) Jan Klohs et al.   BASIC RESEARCH IN CARDIOLOGY

Smart optical probes for near-infrared fluorescence imaging of Alzheimer’s disease pathology

(2008) Scott B. Raymond et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Biochemistry of Tau in Alzheimer’s disease and related neurological disorders

(2008) Nicolas Sergeant et al.   Expert Review of Proteomics

Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer

(2008) Rakez Kayed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multicenter Standardized 18F-FDG PET Diagnosis of Mild Cognitive Impairment, Alzheimer's Disease, and Other Dementias

(2008) L. Mosconi et al.   JOURNAL OF NUCLEAR MEDICINE

Imaging of amyloid β in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism

(2008) Christopher C Rowe et al.   LANCET NEUROLOGY

Unknown

(2008) G Irvine et al.   MOLECULAR MEDICINE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Hybrid FMT–CT imaging of amyloid-β plaques in a murine Alzheimer's disease model

(2008) D HYDE et al.   NEUROIMAGE

Near-Infrared Fluorophores Containing Benzo[c]heterocycle Subunits

(2008) Scott T. Meek et al.   ORGANIC LETTERS

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE

The Chemistry of Fluorescent Bodipy Dyes: Versatility Unsurpassed

(2007) Gilles Ulrich et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION