Oxalate-curcumin–based probe for micro- and macroimaging of reactive oxygen species in Alzheimer’s disease

Imaging Reactive Oxygen Species-Induced Modifications in Living Systems

(2016) Giuseppe Maulucci et al.   ANTIOXIDANTS & REDOX SIGNALING

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging

(2016) J. K. Hefendehl et al.   Nature Communications

Development of Imidazoline-2-Thiones Based Two-Photon Fluorescence Probes for Imaging Hypochlorite Generation in a Co-Culture System

(2015) Qingling Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Vascular dementia

(2015) John T O'Brien et al.   LANCET

Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease

(2015) Xueli Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

(2015) Carlo Condello et al.   Nature Communications

A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease

(2014) Xueli Zhang et al.   CHEMICAL COMMUNICATIONS

H- and J-Aggregation of Fluorene-Based Chromophores

(2014) Yonghong Deng et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing

(2014) Adam J Shuhendler et al.   NATURE BIOTECHNOLOGY

Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes in living mice

(2014) Kanyi Pu et al.   Nature Nanotechnology

Recent advances in hydrogen peroxide imaging for biological applications

(2014) Hengchang Guo et al.   Cell and Bioscience

Genetically Encoded Fluorescent Probe for the Selective Detection of Peroxynitrite

(2013) Zhi-jie Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and Synthesis of Curcumin Analogues for in Vivo Fluorescence Imaging and Inhibiting Copper-Induced Cross-Linking of Amyloid Beta Species in Alzheimer’s Disease

(2013) Xueli Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Contribution of Reactive Oxygen Species to the Photobleaching of Organic Fluorophores

(2013) Qinsi Zheng et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Rapid cell death is preceded by amyloid plaque-mediated oxidative stress

(2013) H. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Lysosome-Targetable and Two-Photon Fluorescent Probe for Monitoring Endogenous and Exogenous Nitric Oxide in Living Cells

(2012) Haibo Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Three-Channel Fluorescent Probe That Distinguishes Peroxynitrite from Hypochlorite

(2012) Quanjuan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Detection of Hydrogen Peroxide in vitro and in vivo Using Peroxalate Chemiluminescent Micelles

(2011) Il-Jae Lee et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Development of an Si-Rhodamine-Based Far-Red to Near-Infrared Fluorescence Probe Selective for Hypochlorous Acid and Its Applications for Biological Imaging

(2011) Yuichiro Koide et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Near-IR Reversible Fluorescent Probe Modulated by Selenium for Monitoring Peroxynitrite and Imaging in Living Cells

(2011) Fabiao Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of a Highly Sensitive Fluorescence Probe for Hydrogen Peroxide

(2011) Masahiro Abo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Unique Paradigm for a Turn-ON Near-Infrared Cyanine-Based Probe: Noninvasive Intravital Optical Imaging of Hydrogen Peroxide

(2011) Naama Karton-Lifshin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

Non-Conjugated Small Molecule FRET for Differentiating Monomers from Higher Molecular Weight Amyloid Beta Species

(2011) Chongzhao Ran et al.   PLoS One

Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition

(2011) Carlo Condello et al.   Scientific Reports

Direct Detection of Nitroxyl in Aqueous Solution Using a Tripodal Copper(II) BODIPY Complex

(2010) Joel Rosenthal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mitochondrial-targeted fluorescent probes for reactive oxygen species

(2009) Bryan C Dickinson et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Design, Synthesis, and Testing of Difluoroboron-Derivatized Curcumins as Near-Infrared Probes for in Vivo Detection of Amyloid-β Deposits

(2009) Chongzhao Ran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrocyanines: A Class of Fluorescent Sensors That Can Image Reactive Oxygen Species in Cell Culture, Tissue, and In Vivo

(2008) Kousik Kundu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance

(2008) T. Bolmont et al.   JOURNAL OF NEUROSCIENCE

A Targetable Fluorescent Probe for Imaging Hydrogen Peroxide in the Mitochondria of Living Cells

(2008) Bryan C. Dickinson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neuroscience: The plaque plan

(2008) Alison Abbott   NATURE

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

Therapeutics for Alzheimer’s disease based on the metal hypothesis

(2008) Ashley I. Bush et al.   Neurotherapeutics