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TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

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Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model

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Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection

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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

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Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction

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STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

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Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition

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Mitochondrial DNA Damage Level Determines Neural Stem Cell Differentiation Fate

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(2010) Rongbin Zhou et al.   NATURE

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

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