Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria
出版年份 2018 全文链接
标题
Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria
作者
关键词
-
出版物
Nature Communications
Volume 9, Issue 1, Pages -
出版商
Springer Nature
发表日期
2018-04-04
DOI
10.1038/s41467-018-03552-x
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- MtDNA-maintenance defects: syndromes and genes
- (2017) Carlo Viscomi et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Characterizing the mitochondrial DNA polymerase gamma interactome by BioID identifies Ruvbl2 localizes to the mitochondria
- (2017) Sanduni U. Liyanage et al. MITOCHONDRION
- Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals
- (2017) Inge Kühl et al. eLife
- Human mitochondrial DNA replication machinery and disease
- (2016) Matthew J Young et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- MGME1 processes flaps into ligatable nicks in concert with DNA polymerase γ during mtDNA replication
- (2016) Jay P. Uhler et al. NUCLEIC ACIDS RESEARCH
- Mitochondrial transcription termination factor 1 directs polar replication fork pausing
- (2016) Yonghong Shi et al. NUCLEIC ACIDS RESEARCH
- MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria
- (2016) Ilaria Dalla Rosa et al. PLoS Genetics
- POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA
- (2016) I. Ku hl et al. Science Advances
- RNASEH1 Mutations Impair mtDNA Replication and Cause Adult-Onset Mitochondrial Encephalomyopathy
- (2015) Aurelio Reyes et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Primer removal during mammalian mitochondrial DNA replication
- (2015) Jay P. Uhler et al. DNA REPAIR
- Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence element
- (2015) Elisabeth Jemt et al. NUCLEIC ACIDS RESEARCH
- Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid
- (2015) Christian Kukat et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies
- (2015) Ana Bratic et al. Nature Communications
- The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication
- (2015) Bertil Macao et al. Nature Communications
- MtDNA mutagenesis impairs elimination of mitochondria during erythroid maturation leading to enhanced erythrocyte destruction
- (2015) K.J. Ahlqvist et al. Nature Communications
- The Respiratory Chain Supercomplex Organization Is Independent of COX7a2l Isoforms
- (2014) Arnaud Mourier et al. Cell Metabolism
- In D-loop: 40years of mitochondrial 7S DNA
- (2014) Thomas J. Nicholls et al. EXPERIMENTAL GERONTOLOGY
- Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease
- (2014) Thomas J. Nicholls et al. HUMAN MOLECULAR GENETICS
- Mutations in DNA2 Link Progressive Myopathy to Mitochondrial DNA Instability
- (2013) Dario Ronchi et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Mitochondrial genetics
- (2013) P. F. Chinnery et al. BRITISH MEDICAL BULLETIN
- MTERF1 Binds mtDNA to Prevent Transcriptional Interference at the Light-Strand Promoter but Is Dispensable for rRNA Gene Transcription Regulation
- (2013) Mügen Terzioglu et al. Cell Metabolism
- TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication
- (2013) D. Milenkovic et al. HUMAN MOLECULAR GENETICS
- Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease
- (2013) Cornelia Kornblum et al. NATURE GENETICS
- Identification of a novel human mitochondrial endo-/exonuclease Ddk1/c20orf72 necessary for maintenance of proper 7S DNA levels
- (2013) Roman J. Szczesny et al. NUCLEIC ACIDS RESEARCH
- Next-generation sequencing reveals DGUOK mutations in adult patients with mitochondrial DNA multiple deletions
- (2012) D. Ronchi et al. BRAIN
- A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop
- (2012) P. H. Wanrooij et al. NUCLEIC ACIDS RESEARCH
- Modeling Pathogenic Mutations of Human Twinkle in Drosophila Suggests an Apoptosis Role in Response to Mitochondrial Defects
- (2012) Alvaro Sanchez-Martinez et al. PLoS One
- Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA
- (2011) C. Kukat et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins
- (2011) Adam Ameur et al. PLoS Genetics
- Somatic Mitochondrial DNA Mutations in Mammalian Aging
- (2010) Nils-Göran Larsson Annual Review of Biochemistry
- Mouse models of mtDNA replication diseases
- (2010) Henna Tyynismaa et al. METHODS
- Maintenance of respiratory chain function in mouse hearts with severely impaired mtDNA transcription
- (2010) Christoph Freyer et al. NUCLEIC ACIDS RESEARCH
- Random Point Mutations with Major Effects on Protein-Coding Genes Are the Driving Force behind Premature Aging in mtDNA Mutator Mice
- (2009) Daniel Edgar et al. Cell Metabolism
- Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA
- (2009) Laura J. Bailey et al. NUCLEIC ACIDS RESEARCH
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now