Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site

Gene expression analysis identifies global gene dosage sensitivity in cancer

(2015) Rudolf S N Fehrmann et al.   NATURE GENETICS

The Overexpression of FEN1 and RAD54B May Act as Independent Prognostic Factors of Lung Adenocarcinoma

(2015) Jau-Chung Hwang et al.   PLoS One

CtIP mediates replication fork recovery in a FANCD2-regulated manner

(2014) Jung Eun Yeo et al.   HUMAN MOLECULAR GENETICS

Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice

(2014) Nozomi Tomimatsu et al.   Nature Communications

Pharmacokinetics and the drug–target residence time concept

(2013) Göran Dahl et al.   DRUG DISCOVERY TODAY

Proline Scanning Mutagenesis Reveals a Role for the Flap Endonuclease-1 Helical Cap in Substrate Unpairing

(2013) Nikesh Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibiting the HIV Integration Process: Past, Present, and the Future

(2013) Roberto Di Santo   JOURNAL OF MEDICINAL CHEMISTRY

Single-molecule characterization of Fen1 and Fen1/PCNA complexes acting on flap substrates

(2013) Timothy D. Craggs et al.   NUCLEIC ACIDS RESEARCH

Observation of unpaired substrate DNA in the flap endonuclease-1 active site

(2013) L. David Finger et al.   NUCLEIC ACIDS RESEARCH

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Exonuclease 1 is a Critical Mediator of Survival During DNA Double Strand Break Repair in Nonquiescent Hematopoietic Stem and Progenitor Cells

(2013) Amar Desai et al.   STEM CELLS

An Evolutionarily Conserved Synthetic Lethal Interaction Network Identifies FEN1 as a Broad-Spectrum Target for Anticancer Therapeutic Development

(2013) Derek M. van Pel et al.   PLoS Genetics

High-Precision Isothermal Titration Calorimetry with Automated Peak-Shape Analysis

(2012) Sandro Keller et al.   ANALYTICAL CHEMISTRY

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

Base Excision Repair: Contribution to Tumorigenesis and Target in Anticancer Treatment Paradigms

(2012) J. L. Illuzzi et al.   CURRENT MEDICINAL CHEMISTRY

Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions

(2012) Nozomi Tomimatsu et al.   DNA REPAIR

Sequential Posttranslational Modifications Program FEN1 Degradation during Cell-Cycle Progression

(2012) Zhigang Guo et al.   MOLECULAR CELL

Flap endonucleases pass 5′-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5′-ends

(2012) Nikesh Patel et al.   NUCLEIC ACIDS RESEARCH

Telomerase-Independent Paths to Immortality in Predictable Cancer Subtypes

(2012) Stephen T Durant   Journal of Cancer

Complex DNA repair pathways as possible therapeutic targets to overcome temozolomide resistance in glioblastoma

(2012) Koji Yoshimoto et al.   Frontiers in Oncology

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

(2011) Susan E. Tsutakawa et al.   CELL

Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family

(2011) Jillian Orans et al.   CELL

Neutralizing Mutations of Carboxylates That Bind Metal 2 in T5 Flap Endonuclease Result in an Enzyme That Still Requires Two Metal Ions

(2011) Christopher G. Tomlinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and biochemical studies of the 5′→3′ exoribonuclease Xrn1

(2011) Jeong Ho Chang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases

(2011) Jane A. Grasby et al.   TRENDS IN BIOCHEMICAL SCIENCES

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Functional regulation of FEN1 nuclease and its link to cancer

(2010) L. Zheng et al.   NUCLEIC ACIDS RESEARCH

Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity

(2010) Dorjbal Dorjsuren et al.   NUCLEIC ACIDS RESEARCH

How the Fanconi Anemia Pathway Guards the Genome

(2009) George-Lucian Moldovan et al.   Annual Review of Genetics

Amino Acid Asp181 of 5′-Flap Endonuclease 1 Is a Useful Target for Chemotherapeutic Development

(2009) Harekrushna Panda et al.   BIOCHEMISTRY

The 3′-Flap Pocket of Human Flap Endonuclease 1 Is Critical for Substrate Binding and Catalysis

(2009) L. David Finger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks

(2009) Emma Bolderson et al.   NUCLEIC ACIDS RESEARCH

Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing

(2009) K. J. McManus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three Metal Ions Participate in the Reaction Catalyzed by T5 Flap Endonuclease

(2008) Karl Syson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY