Cancer-associated fibroblasts: Vital suppressors of the immune response in the tumor microenvironment

Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

(2022) Shogo Kumagai et al.   CANCER CELL

Cancer‐associated fibroblast‐mediated cellular crosstalk supports hepatocellular carcinoma progression

(2021) Mengjia Song et al.   HEPATOLOGY

Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype

(2021) Shaolin Ma et al.   Cell Reports

Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment

(2021) Zhibo Xie et al.   GUT

GPR30 knockdown weakens the capacity of CAF in promoting prostate cancer cell invasion via reducing macrophage infiltration and M2 polarization

(2021) Ran Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity

(2021) Colin Hutton et al.   CANCER CELL

TGFβ Signaling Activated by Cancer-Associated Fibroblasts Determines the Histological Signature of Lung Adenocarcinoma

(2021) Ryo Sato et al.   CANCER RESEARCH

Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy

(2021) Ana Luísa Correia et al.   NATURE

Fibroblast Activation Protein-α as a Target in the Bench-to-Bedside Diagnosis and Treatment of Tumors: A Narrative Review

(2021) Lei Xin et al.   Frontiers in Oncology

Prognostic significance and therapeutic implications of Caveolin-1 in gastrointestinal tract malignancies

(2021) Konstantinos Kamposioras et al.   PHARMACOLOGY & THERAPEUTICS

Lactate in the tumour microenvironment: From immune modulation to therapy

(2021) Zi-Hao Wang et al.   EBioMedicine

Vimentin Is at the Heart of Epithelial Mesenchymal Transition (EMT) Mediated Metastasis

(2021) Saima Usman et al.   Cancers

NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors

(2020) Kirsty Ford et al.   CANCER RESEARCH

Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms

(2020) Floriane Pelon et al.   Nature Communications

Cancer-associated fibroblasts promote immunosuppression by inducing ROS-generating monocytic MDSCs in lung squamous cell carcinoma

(2020) Handan Xiang et al.   Cancer Immunology Research

DIVERSITY AND BIOLOGY OF CANCER-ASSOCIATED FIBROBLASTS

(2020) Giulia Biffi et al.   PHYSIOLOGICAL REVIEWS

TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking

(2020) Andrew J. Gunderson et al.   Nature Communications

Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer

(2020) Yann Kieffer et al.   Cancer Discovery

Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer

(2020) Aimy Sebastian et al.   Cancers

Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer

(2020) Sunny Z Wu et al.   EMBO JOURNAL

Enhancer Reprogramming within Pre-existing Topologically Associated Domains Promotes TGF-β-Induced EMT and Cancer Metastasis

(2020) Yunbo Qiao et al.   MOLECULAR THERAPY

TGFβ biology in cancer progression and immunotherapy

(2020) Rik Derynck et al.   Nature Reviews Clinical Oncology

Oxidative stress induces monocyte‐to‐myofibroblast transdifferentiation through p38 in pancreatic ductal adenocarcinoma

(2020) Xin Huang et al.   Clinical and Translational Medicine

Fibroblast-derived IL-33 facilitates breast cancer metastasis by modifying the immune microenvironment and driving type-2 immunity

(2020) Ophir Shani et al.   CANCER RESEARCH

Stromal SNAI2 is required for ERBB2 breast cancer progression

(2020) Adrián Blanco-Gómez et al.   CANCER RESEARCH

A Wnt-induced phenotypic switch in cancer-associated fibroblasts inhibits EMT in colorectal cancer

(2020) Mohammed H. Mosa et al.   CANCER RESEARCH

Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma

(2020) Zhaohui Chen et al.   Nature Communications

Cancer-Associated Fibroblast Mediated Inhibition of CD8+ Cytotoxic T Cell Accumulation in Tumours: Mechanisms and Therapeutic Opportunities

(2020) Patrick Freeman et al.   Cancers

Thrombospondin‐4 mediates hyperglycemia‐ and TGF ‐beta‐induced inflammation in breast cancer

(2020) Santoshi Muppala et al.   INTERNATIONAL JOURNAL OF CANCER

Lactate modulates CD4+ T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis

(2019) G. Comito et al.   ONCOGENE

Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer

(2019) Rongsheng Zhang et al.   Cell Death & Disease

Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma

(2019) Andrew J. Gunderson et al.   PLoS One

Biological heterogeneity and versatility of cancer-associated fibroblasts in the tumor microenvironment

(2019) Luke Bu et al.   ONCOGENE

Impact of Epithelial–Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ

(2019) Carina Strell et al.   JNCI-Journal of the National Cancer Institute

In search of definitions: Cancer-associated fibroblasts and their markers

(2019) Martin Nurmik et al.   INTERNATIONAL JOURNAL OF CANCER

Dual blockade of CXCL12-CXCR4 and PD-1–PD-L1 pathways prolongs survival of ovarian tumor–bearing mice by prevention of immunosuppression in the tumor microenvironment

(2019) Yang Zeng et al.   FASEB JOURNAL

Novel Transforming Growth Factor Beta Receptor I Kinase Inhibitor Galunisertib ( LY 2157299) in Advanced Hepatocellular Carcinoma

(2019) Sandrine Faivre et al.   LIVER INTERNATIONAL

Targeting interleukin-6 as a strategy to overcome stroma-induced resistance to chemotherapy in gastric cancer

(2019) In-Hye Ham et al.   Molecular Cancer

The Tumor Microenvironment Innately Modulates Cancer Progression

(2019) Dominique C. Hinshaw et al.   CANCER RESEARCH

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

Human Pancreatic Carcinoma-Associated Fibroblasts Promote Expression of Co-inhibitory Markers on CD4+ and CD8+ T-Cells

(2019) Laia Gorchs et al.   Frontiers in Immunology

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy

(2019) Tongyan Liu et al.   Journal of Hematology & Oncology

Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins

(2019) Cédric Zeltz et al.   SEMINARS IN CANCER BIOLOGY

Dualism of FGF and TGF-β Signaling in Heterogeneous Cancer-Associated Fibroblast Activation with ETV1 as a Critical Determinant

(2019) Pino Bordignon et al.   Cell Reports

PD-L1 Induction by Cancer-Associated Fibroblast-Derived Factors in Lung Adenocarcinoma Cells

(2019) Inoue et al.   Cancers

Activated hepatic stellate cells regulate MDSC migration through the SDF-1/CXCR4 axis in an orthotopic mouse model of hepatocellular carcinoma

(2019) Yaping Xu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis

(2019) Nour Ershaid et al.   Nature Communications

White Adipocyte Plasticity in Physiology and Disease

(2019) Ewa Bielczyk-Maczynska   Cells

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

IL-6 mediates cross-talk between activated fibroblasts and tumor cells in the tumor microenvironment

(2018) Tatiana A Karakasheva et al.   CANCER RESEARCH

Podoplanin: An emerging cancer biomarker and therapeutic target

(2018) Harini Krishnan et al.   CANCER SCIENCE

CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

(2018) Shicheng Su et al.   CELL

Cancer-Associated Fibroblasts Affect Intratumoral CD8+and FoxP3+T Cells via Interleukin 6 in the Tumor Microenvironment

(2018) Takuya Kato et al.   CLINICAL CANCER RESEARCH

Endoglin expression on cancer-associated fibroblasts regulates invasion and stimulates colorectal cancer metastasis

(2018) Madelon Paauwe et al.   CLINICAL CANCER RESEARCH

Cancer-stimulated CAFs enhance monocyte differentiation and pro-tumoral TAM activation via IL-6 and GM-CSF secretion

(2018) Haaglim Cho et al.   CLINICAL CANCER RESEARCH

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

A short field guide to fibroblast function in immunity

(2018) Matthew B. Buechler et al.   SEMINARS IN IMMUNOLOGY

Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma

(2018) Yusheng Cheng et al.   Cell Death & Disease

miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers

(2018) Anne-Marie Givel et al.   Nature Communications

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

(2018) Rajani Ravi et al.   Nature Communications

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade

(2018) Rikke B. Holmgaard et al.   Journal for ImmunoTherapy of Cancer

The role of PDGF-B/PDGFR-BETA axis in the normal development and carcinogenesis of the breast

(2018) Adriana-Andreea Jitariu et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

Heterogeneous cancer-associated fibroblast population potentiates neuroendocrine differentiation and castrate resistance in a CD105-dependent manner

(2018) Manabu Kato et al.   ONCOGENE

FAP delineates heterogeneous and functionally divergent stromal cells in immune-excluded breast tumors

(2018) Viviana Cremasco et al.   Cancer Immunology Research

Galunisertib plus gemcitabine vs. gemcitabine for first-line treatment of patients with unresectable pancreatic cancer

(2018) Davide Melisi et al.   BRITISH JOURNAL OF CANCER

Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer

(2018) Delphine Goehrig et al.   GUT

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

(2017) Huipeng Li et al.   NATURE GENETICS

Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1

(2017) N Cohen et al.   ONCOGENE

TGF-β Family Signaling in Tumor Suppression and Cancer Progression

(2017) Joan Seoane et al.   Cold Spring Harbor Perspectives in Biology

Melanoma-associated fibroblasts decrease tumor cell susceptibility to NK cell-mediated killing through matrix-metalloproteinases secretion

(2017) Linda Ziani et al.   Oncotarget

Improvement of anti-tumor immunity of fibroblast activation protein α based vaccines by combination with cyclophosphamide in a murine model of breast cancer

(2016) Qiu Xia et al.   CELLULAR IMMUNOLOGY

IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer

(2016) Thomas A Mace et al.   GUT

Cyclophosphamide enhances anti-tumor effects of a fibroblast activation protein α-based DNA vaccine in tumor-bearing mice with murine breast carcinoma

(2016) Qiu Xia et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial

(2016) Timothy M Nywening et al.   LANCET ONCOLOGY

RG7386, a Novel Tetravalent FAP-DR5 Antibody, Effectively Triggers FAP-Dependent, Avidity-Driven DR5 Hyperclustering and Tumor Cell Apoptosis

(2016) P. Bru nker et al.   MOLECULAR CANCER THERAPEUTICS

Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets

(2016) Yufang Shi et al.   NATURE REVIEWS DRUG DISCOVERY

Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells

(2016) Y Deng et al.   ONCOGENE

Tumor-associated fibroblasts predominantly come from local and not circulating precursors

(2016) Ainhoa Arina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

(2016) Sébastien Viel et al.   Science Signaling

Mesenchymal Stem Cells are Recruited and Activated into Carcinoma-Associated Fibroblasts by Prostate Cancer Microenvironment-Derived TGF-β1

(2016) Pedro Barcellos-de-Souza et al.   STEM CELLS

Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers

(2016) Roni Allaoui et al.   Nature Communications

Depletion of FAP+ cells reduces immunosuppressive cells and improves metabolism and functions CD8+T cells within tumors

(2016) Ying Zhang et al.   Oncotarget

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

(2016) Sébastien Viel et al.   Science Signaling

Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation

(2016) J-t Cheng et al.   Oncogenesis

Immune response modulation by Galectin-1 in a transgenic model of neuroblastoma

(2016) Gabriele Büchel et al.   OncoImmunology

A multi-antigen vaccine in combination with an immunotoxin targeting tumor-associated fibroblast for treating murine melanoma

(2016) Jinxu Fang et al.   Molecular Therapy-Oncolytics

A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer

(2015) E. M. Dijkgraaf et al.   ANNALS OF ONCOLOGY

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2015) Berna C. Özdemir et al.   CANCER CELL

Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells

(2015) A. Lo et al.   CANCER RESEARCH

Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in dendritic cell-based vaccine

(2015) Yasuhiko Ohshio et al.   CANCER SCIENCE

A potent immunotoxin targeting fibroblast activation protein for treatment of breast cancer in mice

(2015) Jinxu Fang et al.   INTERNATIONAL JOURNAL OF CANCER

CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function

(2015) Eunyoung Chun et al.   Cell Reports

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

(2014) Ruth Scherz-Shouval et al.   CELL

PDGF receptor signaling networks in normal and cancer cells

(2014) Jean-Baptiste Demoulin et al.   CYTOKINE & GROWTH FACTOR REVIEWS

A pro-tumourigenic loop at the human prostate tumour interface orchestrated by oestrogen, CXCL12 and mast cell recruitment

(2014) Stuart J Ellem et al.   JOURNAL OF PATHOLOGY

Osteopontin mediates an MZF1–TGF-β1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer

(2014) C E Weber et al.   ONCOGENE

TGF- -inducible microRNA-183 silences tumor-associated natural killer cells

(2014) S. S. Donatelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tranilast Inhibits the Function of Cancer-Associated Fibroblasts Responsible for the Induction of Immune Suppressor Cell Types

(2014) Y. Ohshio et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

The IL-6–STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression

(2014) Q Zhu et al.   Cell Death & Disease

GRP78 secreted by tumor cells stimulates differentiation of bone marrow mesenchymal stem cells to cancer-associated fibroblasts

(2013) Yanan Peng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer

(2013) Xiongyan Wu et al.   CANCER LETTERS

Docetaxel Conjugate Nanoparticles That Target  -Smooth Muscle Actin-Expressing Stromal Cells Suppress Breast Cancer Metastasis

(2013) M. Murakami et al.   CANCER RESEARCH

Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner

(2013) T. A. Mace et al.   CANCER RESEARCH

Identification of Two Distinct Carcinoma-Associated Fibroblast Subtypes with Differential Tumor-Promoting Abilities in Oral Squamous Cell Carcinoma

(2013) Daniela Elena Costea et al.   CANCER RESEARCH

Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer

(2013) L. Bochet et al.   CANCER RESEARCH

Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma

(2013) Abasi Ene–Obong et al.   GASTROENTEROLOGY

Hepatic stellate cells in liver development, regeneration, and cancer

(2013) Chunyue Yin et al.   JOURNAL OF CLINICAL INVESTIGATION

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia

(2013) Edward W. Roberts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia

(2013) Eric Tran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Roles of PDGF in Development and During Neurogenesis in the Normal and Diseased Nervous System

(2013) Keiko Funa et al.   Journal of Neuroimmune Pharmacology

Colorectal carcinoma-derived fibroblasts modulate natural killer cell phenotype and antitumor cytotoxicity

(2013) Tuanjie Li et al.   MEDICAL ONCOLOGY

Antitumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma

(2013) Sunitha Kakarla et al.   MOLECULAR THERAPY

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Arginase II Expressed in Cancer-Associated Fibroblasts Indicates Tissue Hypoxia and Predicts Poor Outcome in Patients with Pancreatic Cancer

(2013) Yoshinori Ino et al.   PLoS One

A Vaccine That Co-Targets Tumor Cells and Cancer Associated Fibroblasts Results in Enhanced Antitumor Activity by Inducing Antigen Spreading

(2013) Stephen Gottschalk et al.   PLoS One

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis

(2013) Younghun Jung et al.   Nature Communications

Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity

(2013) L.-C. S. Wang et al.   Cancer Immunology Research

Ways to Enhance Lymphocyte Trafficking into Tumors and Fitness of Tumor Infiltrating Lymphocytes

(2013) Matteo Bellone et al.   Frontiers in Oncology

Targeting Carcinoma-Associated Fibroblasts Within the Tumor Stroma With a Fibroblast Activation Protein-Activated Prodrug

(2012) W. N. Brennen et al.   JNCI-Journal of the National Cancer Institute

Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts

(2012) L J A C Hawinkels et al.   ONCOGENE

FSP1+ Fibroblasts Promote Skin Carcinogenesis by Maintaining MCP-1-Mediated Macrophage Infiltration and Chronic Inflammation

(2011) Jinhua Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

(2011) Victoria Sanz-Moreno et al.   CANCER CELL

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

(2011) Michael Quante et al.   CANCER CELL

Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO

(2011) Tuanjie Li et al.   CANCER LETTERS

Retinoic Acid–Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt–β-Catenin Signaling to Slow Tumor Progression

(2011) Fieke E.M. Froeling et al.   GASTROENTEROLOGY

Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation

(2011) Ilona Gutcher et al.   IMMUNITY

Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer

(2011) Lucia De Monte et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Adipose tissue derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor derived factors

(2011) Constantin Jotzu et al.   CELLULAR ONCOLOGY

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers

(2010) A. Saadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autocrine TGF-  and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

(2010) Y. Kojima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein- 

(2010) M. Kraman et al.   SCIENCE

TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

(2010) Li Yang et al.   TRENDS IN IMMUNOLOGY

Phase II assessment of talabostat and cisplatin in second-line stage IV melanoma

(2009) Robert M Eager et al.   BMC CANCER

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

TGF-β modulates the functionality of tumor-infiltrating CD8+ T cells through effects on TCR signaling and Spred1 expression

(2009) Maria Giovanna di Bari et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

Tolerogenic dendritic cells in cancer, transplantation, and autoimmune diseases

(2009) Nicole Suciu-Foca et al.   HUMAN IMMUNOLOGY