Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity
出版年份 2021 全文链接
标题
Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity
作者
关键词
-
出版物
CANCER CELL
Volume 39, Issue 9, Pages 1227-1244.e20
出版商
Elsevier BV
发表日期
2021-07-22
DOI
10.1016/j.ccell.2021.06.017
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Fibroblast Heterogeneity in the Pancreatic Tumor Microenvironment
- (2020) Erin Helms et al. Cancer Discovery
- Stabilized Reconstruction of Signaling Networks from Single-Cell Cue-Response Data
- (2020) Sunil Kumar et al. Scientific Reports
- Mesothelial-to-Mesenchymal Transition Contributes to the Generation of Carcinoma-Associated Fibroblasts in Locally Advanced Primary Colorectal Carcinomas
- (2020) Carlos H. Gordillo et al. Cancers
- Notch signalling drives synovial fibroblast identity and arthritis pathology
- (2020) Kevin Wei et al. NATURE
- The mesenchymal context in inflammation, immunity and cancer
- (2020) Vasiliki Koliaraki et al. NATURE IMMUNOLOGY
- PU.1 controls fibroblast polarization and tissue fibrosis
- (2019) Thomas Wohlfahrt et al. NATURE
- Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer
- (2019) Christopher J. Halbrook et al. Cell Metabolism
- Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling
- (2019) Xiao-Kang Lun et al. MOLECULAR CELL
- Distinct fibroblast subsets drive inflammation and damage in arthritis
- (2019) Adam P. Croft et al. NATURE
- Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring
- (2019) Yu Shi et al. NATURE
- Clonal replacement of tumor-specific T cells following PD-1 blockade
- (2019) Kathryn E. Yost et al. NATURE MEDICINE
- Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts
- (2019) Ela Elyada et al. Cancer Discovery
- Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis
- (2019) Rene Jackstadt et al. CANCER CELL
- Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer
- (2019) Diletta Di Mitri et al. Cell Reports
- Single-cell RNA sequencing reveals stromal evolution into LRRC15+ myofibroblasts as a determinant of patient response to cancer immunotherapy
- (2019) Claudia X Dominguez et al. Cancer Discovery
- CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness
- (2018) Shicheng Su et al. CELL
- Endoglin expression on cancer-associated fibroblasts regulates invasion and stimulates colorectal cancer metastasis
- (2018) Madelon Paauwe et al. CLINICAL CANCER RESEARCH
- Functional molecules in mesothelial-to-mesenchymal transition revealed by transcriptome analyses
- (2018) Sara Namvar et al. JOURNAL OF PATHOLOGY
- Integrating single-cell transcriptomic data across different conditions, technologies, and species
- (2018) Andrew Butler et al. NATURE BIOTECHNOLOGY
- A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade
- (2018) Daniela S. Thommen et al. NATURE MEDICINE
- CellCycleTRACER accounts for cell cycle and volume in mass cytometry data
- (2018) Maria Anna Rapsomaniki et al. Nature Communications
- Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
- (2018) Yannick Simoni et al. NATURE
- Metal-isotope-tagged monoclonal antibodies for high-dimensional mass cytometry
- (2018) Guojun Han et al. Nature Protocols
- Dimensionality reduction for visualizing single-cell data using UMAP
- (2018) Etienne Becht et al. NATURE BIOTECHNOLOGY
- Pathogenic stromal cells as therapeutic targets in joint inflammation
- (2018) Stephanie G. Dakin et al. Nature Reviews Rheumatology
- IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma
- (2018) Giulia Biffi et al. Cancer Discovery
- Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
- (2017) Daniel Öhlund et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Chromatin states define tumour-specific T cell dysfunction and reprogramming
- (2017) Mary Philip et al. NATURE
- Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry
- (2017) Xiao-Kang Lun et al. NATURE BIOTECHNOLOGY
- Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations
- (2017) Susanne C van den Brink et al. NATURE METHODS
- QuPath: Open source software for digital pathology image analysis
- (2017) Peter Bankhead et al. Scientific Reports
- CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma
- (2016) Colin W. Steele et al. CANCER CELL
- Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation
- (2016) Christopher J. Tape et al. CELL
- Single-cell states versus single-cell atlases — two classes of heterogeneity that differ in meaning and method
- (2016) Kevin A Janes CURRENT OPINION IN BIOTECHNOLOGY
- Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
- (2016) Hong Jiang et al. NATURE MEDICINE
- Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
- (2016) I. Tirosh et al. SCIENCE
- Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages
- (2016) Beate M. Lichtenberger et al. Nature Communications
- A Single-Cell Transcriptome Atlas of the Human Pancreas
- (2016) Mauro J. Muraro et al. Cell Systems
- Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling
- (2015) Eishu Hirata et al. CANCER CELL
- FlowSOM: Using self-organizing maps for visualization and interpretation of cytometry data
- (2015) Sofie Van Gassen et al. CYTOMETRY PART A
- Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy
- (2015) Bryan W Miller et al. EMBO Molecular Medicine
- Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer
- (2015) Daniel V.T. Catenacci et al. JOURNAL OF CLINICAL ONCOLOGY
- Palladium-based mass tag cell barcoding with a doublet-filtering scheme and single-cell deconvolution algorithm
- (2015) Eli R Zunder et al. Nature Protocols
- Identification and isolation of a dermal lineage with intrinsic fibrogenic potential
- (2015) Y. Rinkevich et al. SCIENCE
- Understanding fibroblast heterogeneity in the skin
- (2015) Ryan R. Driskell et al. TRENDS IN CELL BIOLOGY
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
- (2014) Berna C. Özdemir et al. CANCER CELL
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma
- (2014) E. J. Kim et al. CLINICAL CANCER RESEARCH
- Concise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells
- (2014) Feng-Juan Lv et al. STEM CELLS
- Wt1-expressing progenitors contribute to multiple tissues in the developing lung
- (2013) Elena Cano et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Derivation of lung mesenchymal lineages from the fetal mesothelium requires hedgehog signaling for mesothelial cell entry
- (2013) R. Dixit et al. DEVELOPMENT
- Distinct fibroblast lineages determine dermal architecture in skin development and repair
- (2013) Ryan R. Driskell et al. NATURE
- Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
- (2013) C. Feig et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
- (2012) Paolo P. Provenzano et al. CANCER CELL
- The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells
- (2012) William J. Harris et al. CANCER CELL
- Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
- (2012) Meredith A. Collins et al. JOURNAL OF CLINICAL INVESTIGATION
- From single cells to deep phenotypes in cancer
- (2012) Sean C Bendall et al. NATURE BIOTECHNOLOGY
- Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs and their vasculature
- (2012) Yuval Rinkevich et al. NATURE CELL BIOLOGY
- Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
- (2011) S. C. Bendall et al. SCIENCE
- Transforming Growth Factor-? and Endoglin Signaling Orchestrate Wound Healing
- (2011) Manoj Valluru et al. Frontiers in Physiology
- Differential expression analysis for sequence count data
- (2010) Simon Anders et al. GENOME BIOLOGY
- flowCore: a Bioconductor package for high throughput flow cytometry
- (2009) Florian Hahne et al. BMC BIOINFORMATICS
- Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice
- (2009) Nathalie Dhomen et al. CANCER CELL
- Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
- (2009) K. P. Olive et al. SCIENCE
- Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity
- (2008) K. Hildner et al. SCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now