Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1

Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation

(2016) H. Schwartz et al.   CANCER RESEARCH

CAFs and TAMs: maestros of the tumour microenvironment

(2016) Yoshihiro Komohara et al.   JOURNAL OF PATHOLOGY

Tumor-Derived Osteopontin Reprograms Normal Mammary Fibroblasts to Promote Inflammation and Tumor Growth in Breast Cancer

(2015) Y. Sharon et al.   CANCER RESEARCH

Association between CD8+ T-cell infiltration and breast cancer survival in 12 439 patients

(2014) H. R. Ali et al.   ANNALS OF ONCOLOGY

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

Role of Chitinase 3-like-1 and Semaphorin 7a in Pulmonary Melanoma Metastasis

(2014) B. Ma et al.   CANCER RESEARCH

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

MicroRNA profiling reveals opposing expression patterns for miR-511 in alternatively and classically activated macrophages

(2014) Danielle Karo-Atar et al.   JOURNAL OF ASTHMA

Chitinase 3-Like 1 Suppresses Injury and Promotes Fibroproliferative Responses in Mammalian Lung Fibrosis

(2014) Y. Zhou et al.   Science Translational Medicine

Cancer Associated Fibroblasts express pro-inflammatory factors in human breast and ovarian tumors

(2013) Neta Erez et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CHI3L1 plays a role in cancer through enhanced production of pro-inflammatory/pro-tumorigenic and angiogenic factors

(2013) Stephania Libreros et al.   IMMUNOLOGIC RESEARCH

Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A

(2013) Fiorenza Lotti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring the role of CHI3L1 in “pre-metastatic” lungs of mammary tumor-bearing mice

(2013) Stephania Libreros et al.   Frontiers in Physiology

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

From sentinel cells to inflammatory culprits: cancer-associated fibroblasts in tumour-related inflammation

(2012) Charlotte Servais et al.   JOURNAL OF PATHOLOGY

Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury

(2011) Chun Geun Lee et al.   Annual Review of Physiology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Induction of proinflammatory mediators by CHI3L1 is reduced by chitin treatment: Decreased tumor metastasis in a breast cancer model

(2011) Stephania Libreros et al.   INTERNATIONAL JOURNAL OF CANCER

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Chitinase 3-like 1 promotes macrophage recruitment and angiogenesis in colorectal cancer

(2011) M Kawada et al.   ONCOGENE

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

(2011) David G. DeNardo et al.   Cancer Discovery

Proliferating macrophages associated with high grade, hormone receptor negative breast cancer and poor clinical outcome

(2010) Michael J. Campbell et al.   BREAST CANCER RESEARCH AND TREATMENT

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Macrophage Expression of Hypoxia-Inducible Factor-1  Suppresses T-Cell Function and Promotes Tumor Progression

(2010) A. L. Doedens et al.   CANCER RESEARCH

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

(2009) David G. DeNardo et al.   CANCER CELL

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

Cancer-associated fibroblasts and tumor growth – bystanders turning into key players

(2009) Arne Östman et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13–induced tissue responses and apoptosis

(2009) Chun Geun Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

YKL-40, a secreted glycoprotein, promotes tumor angiogenesis

(2009) R Shao et al.   ONCOGENE

Cancer Associated Fibroblasts Promote Tumor Growth and Metastasis by Modulating the Tumor Immune Microenvironment in a 4T1 Murine Breast Cancer Model

(2009) Debbie Liao et al.   PLoS One

Potential role of chitinase 3-like-1 in inflammationassociated carcinogenic changes of epithelial cells

(2009) Katrin Eurich et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Macrophages define the invasive microenvironment in breast cancer

(2008) Jeffrey W. Pollard   JOURNAL OF LEUKOCYTE BIOLOGY

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE